<b>REVIEW The renal pathology of mushroom poisoning</b>

O’Donnell, Marie; Fleming, Stewart

doi:10.1046/j.1365-2559.1997.d01-597.x

Cited by 20 publications

(5 citation statements)

References 7 publications

(9 reference statements)

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“…In most cases, renal biopsy shows a picture of predominant interstitial nephritis with a progressive interstitial fibrosis, while glomerular lesions are generally absent . The biopsy of our patient differed from this classical picture, mainly because of the presence of chronic glomerular lesions, a finding probably due to his past history of diabetes, hypertension, and renal dysfunction.…”

Section: Discussionmentioning

confidence: 55%

Renal involvement in mushroom poisoning: The case of Orellanus syndrome

Esposito

Porta

Calatroni

et al. 2015

Hemodialysis International

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Although mushroom poisoning is a rare cause of acute renal injury, in some cases it may lead to the development of a severe and irreversible renal failure. Orellanus syndrome is the most important example of organic renal damage related to mushroom consumption. It is caused by the ingestion of orellanine, the main toxin of different types of Cortinarius mushrooms (Cortinarius speciosissimus, C. orellanus, C. orellanoides, etc.), and it is characterized by progressive clinical phases with a predominant kidney involvement, finally requiring renal replacement therapy in about 10% of cases. Renal damage is often late and associated with a histological picture of interstitial nephritis. Diagnosis is essentially clinical and no specific therapy has been shown to be effective in preventing and treating renal damage. Here, we describe the case of a patient with mixed wild mushroom poisoning, presenting the typical clinical signs and course of the Orellanus syndrome. This case offers us the opportunity to review the main clinical features of this severe and little-known intoxication.

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Section: Discussionmentioning

confidence: 55%

Renal involvement in mushroom poisoning: The case of Orellanus syndrome

Esposito

Porta

Calatroni

et al. 2015

Hemodialysis International

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“…Atlikus inkstų biopsiją, pastebimas intersticinis nefritas su progresuojančia fibroze, nors glomerulų pažeidimų nėra [21]. Kai kuriose šalyse, nesant galimybės ištirti arba pamatyti vartotus grybus, naudojamas tiesioginis orelanino toksino radimas inkstų biopsijoje plono sluoksnio chromatografijos būdu, tačiau tai nėra paplitę [22].…”

Section: Orelano Sindromasunclassified

Dažniausi Apsinuodijimo Grybais Sindromai Ir Inkstų Pažeidimai

Rėkutė¹,

Miglinas

Rimševičius

2017

Medicinos Teorija Ir Praktika

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SANTRAUKAReikšminiai žodžiai: grybai, apsinuodijimai, amanitinas, orelaninas, inkstai. Apsinuodijimas grybais yra reta ūminių inkstų ir kepenų pažeidimų priežastis, tačiau gali sukelti rimtų sveikatos sutrikimų ir baigtis mirtimi. Lietuvoje dažniausiai apsinuodijama musmirėmis (Amanita genties grybais) ir nuodingaisiais nuosėdžiais (Cortinarius orellanus), kurie atitinkamai sukelia Amanitino ir Orelano sindromus. Užsienyje nustatyta rabdomiolizės sukeltų mirties atvejų apsinuodijus nuodingąja ūmėde (Russula subnigricans). Apsinuodijus grybais, atsiranda ankstyvųjų simptomų -pykinimas, vėmimas, viduriavimas, arba vėlyvųjų -negrįžtamų inkstų ir kepenų pažeidimų, elektrolitų disbalansas, kvėpa-vimo ir kardiovaskulinės sistemos pokyčių. Intoksikacijos veikimo mechanizmas siejamas su DNR bei RNR sintezės inhibicija, oksidaciniais ląstelės pažeidimais. Lietuvoje diagnozė remiasi klinika ir surinkta anamneze, užsienyje atliekama inkstų biopsija ir ieškoma histologinių pokyčių. Specifinio gydymo nėra. Efektyviausias gydymas -palaikomasis: agresyvus skysčių atstatymas, elektrolitų balanso palaikymas, gyvybiškai svarbių funkcijų stabilizavimas. Sunkiais atvejais atliekama inkstų ar/ ir kepenų transplantacija. Norint apsaugoti save ir aplinkinius nuo apsinuodijimo grybais, svarbu atpažinti valgomus grybus, tinkamai apdoroti prieš valgant bei riboti vartojamų grybų kiekį. ABSTRACTKey words: mushrooms, poisoning, amanitin, orellanine, kidney. Although mushroom poisoning is a rare cause of renal and liver diseases, it can result in serious health problems and even death. In Lithuania, the most common poisonous mushrooms are Amanita phalloides (Amanita family) and Cortinarius orellanus (Cortinarius family), which respectively causes Amanitin and Orellanus syndromes. In foreign countries, Russula subnigricans (Russulaceae family) poisoning it is not unusual, which may cause rhabdomyolysis induced death. Early symptoms of mushroom poisoning are sickness, vomiting, diarrhea, while advanced symptoms include irreversible kidney and liver injury, electrolytes imbalance, respiratory and cardiovascular system disorders. Mushroom caused intoxication is linked with DNA and RNA synthesis inhibition and oxidative cell damage. In Lithuania, mushroom poisoning diagnosis is primarily based on clinical evidence and anamnesis, while in foreign countries kidney biopsy is also a common procedure. However, there is no specific therapy for mushroom poisoning and, hence, treatment is mainly supportive. In severe cases, kidney or/and liver transplantation may be necessary. Serious health disorders, which result from mushroom poisoning, highlight the importance to spread knowledge about the potential nephrotoxicity of mushrooms, proper preparation and even limited consumption. Skirmantė Rėkutė VUL Santariškių klinikos Santariškių g. 2, Vilnius

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“…23 Renal biopsies of patients with renal failure after the ingestion of Cortinarius mushrooms demonstrate nonspecifi c tubulointerstitial changes with marked edema, patchy tubular necrosis, and mild mononuclear infl ammatory infi ltrates. 27 Healing occurs via fi brosis with variable amounts of tubular atrophy, patchy tubular loss, and renal dysfunction. The glomeruli are usually preserved with little if any mesangial reaction, and the renal vessels are patent.…”

Section: Mechanism Of Toxicitymentioning

confidence: 99%

Orellanine‐Containing Mushrooms and Nephrotoxicity (CortinariusSpecies)

Barceloux

2008

Medical Toxicology of Natural Substances

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REVIEW The renal pathology of mushroom poisoning

Cited by 20 publications

References 7 publications

Renal involvement in mushroom poisoning: The case of Orellanus syndrome

Renal involvement in mushroom poisoning: The case of Orellanus syndrome

Dažniausi Apsinuodijimo Grybais Sindromai Ir Inkstų Pažeidimai

Orellanine‐Containing Mushrooms and Nephrotoxicity (CortinariusSpecies)

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