B (Reg) Cells in Hepatitis C Virus and Diabetes

Hassanin, Khaled Mohammed; Bakr, Omnia Hassan; Hetta, Helal F; Malek, Mohamed Omar Abdel; Mohammed, Fadwa

doi:10.21608/bfsa.2019.62254

Cited by 1 publication

(1 citation statement)

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“…Thus, it was claimed to play a pathogenic role in different autoimmune diseases as rheumatoid arthritis, lupus, autoimmune diabetes mellitus and autoimmune encephalomyelitis. [14][15][16][17][18][19][20] Yet, the regulatory role of B cells in BD has not been thoroughly investigated, 21 and their role in different disease presentations has not been studied. Therefore, the aim of the current study is to identify the proportions of total B lymphocytes and their regulatory subset in different BD phenotypes and therapies attempting to unravel their function in BD.…”

Section: Introductionmentioning

confidence: 99%

Possible Role of Regulatory B Cells in Different Behçet’s Disease Phenotypes and Therapies: First Report from Egypt

Hetta¹,

Mohamed²,

Zahran³

et al. 2021

JIR

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Background and Aim The data about the role of regulatory B cells (Breg) in Behcet Disease (BD) are scarce. We aimed to evaluate the frequency of total B lymphocytes and Breg cells in different BD phenotypes and therapies attempting to unravel their function. Methods This cross-sectional study included 35 BD patients and 39 healthy controls (HCs). The demographic data of the study subjects were collected including age and gender. Current medications including disease-modifying anti-rheumatic drugs (DMARDs) were recorded. All patients underwent testing for baseline laboratory investigations including full blood count, liver and kidney function tests, erythrocyte sedimentation rate (ESR) by Westergren blot and C-reactive protein (CRP). Measurement of the total B lymphocytes and their subtypes B regulatory lymphocytes by flow cytometric assay. Assessment of BD activity was done using the revised Behçet’s Disease Current Activity Form (BDCAF) 2006 and Behçet’s Syndrome Activity Score (BSAS) 1111111111 . All participants were assessed for the presence of erectile dysfunction using the International Index of Erectile Function (IIEF-5 score), and for depression using the Beck Depression Inventory. Results A dramatic drop in the number of B cells, total and regulatory, was observed in the patients compared to the HCs. Regulatory cells (Bregs) tend to be upregulated with genital ulcers or vascular disease. Bregs but not B lymphocytes were associated with BSAS and ESR. Neither the total B lymphocytes nor the Bregs correlated with CRP or the sexual function or depression scores. Of all the used medications, low-dose aspirin was seen with markedly high Bregs proportions. Conclusion This study supports the role of B cells in BD pathogenesis and strongly suggests a possible role for Bregs in the resolution of different BD manifestations.

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