Recent Advances in Electrospinning Techniques for Precise Medicine

Abstract

In the realm of precise medicine, the advancement of manufacturing technologies is vital for enhancing the capabilities of medical devices such as nano/microrobots, wearable/implantable biosensors, and organ-on-chip systems, which serve to accurately acquire and analyze patients’ physiopathological information and to perform patient-specific therapy. Electrospinning holds great promise in engineering materials and components for advanced medical devices, due to the demonstrated ability to advance the development of nanomaterial science. Nevertheless, challenges such as limited composition variety, uncontrollable fiber orientation, difficulties in incorporating fragile molecules and cells, and low production effectiveness hindered its further application. To overcome these challenges, advanced electrospinning techniques have been explored to manufacture functional composites, orchestrated structures, living constructs, and scale-up fabrication. This review delves into the recent advances of electrospinning techniques and underscores their potential in revolutionizing the field of precise medicine, upon introducing the fundamental information of conventional electrospinning techniques, as well as discussing the current challenges and future perspectives.

Review of the Applications of Micro/Nanorobots in Biomedicine

“…Including medical imaging and diagnosis, drug targeted delivery and release, and minimally invasive surgery. 36 Table 1 summarizes the classification of micro/nanorobots based on manufacturing methods. Therefore, this section will summarize the relevant manufacturing design methods from three classification perspectives of micro/ nanorobots.…”

“…In other words, different types of micro/nanorobots manufacturing methods need to be comprehensively considered to meet the comprehensive needs of biomedical research. Including medical imaging and diagnosis, drug targeted delivery and release, and minimally invasive surgery Table summarizes the classification of micro/nanorobots based on manufacturing methods.…”