B Quiet: Autoantigen-Specific Strategies to Silence Raucous B Lymphocytes and Halt Cross-Talk with T Cells in Type 1 Diabetes

Felton, Jamie L.; Conway, Holly; Bonami, Rachel H.

doi:10.3390/biomedicines9010042

Cited by 7 publications

(6 citation statements)

References 97 publications

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“…Type 1 diabetes mellitus (T1DM)(24) is an autoimmune disease that results in the destruction of insulin-producing pancreatic beta cells. Some studies suggest that T cells and B cells play a crucial role(25) in the pathogenesis of diseases. It has been shown(26) that β-cell-targeting autoantibodies targeting insulin or GAD65 can be detected in the serum early in the onset of type 1 diabetes.…”

Section: Discussionmentioning

confidence: 99%

Diabetes, glycaemic profile and risk of vitiligo: a Mendelian randomisation study

Hu,

Che,

Cai

et al. 2023

Preprint

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ObjectivesPrevious observational studies have shown that vitiligo usually co-manifests with a variety of dysglycemic diseases, such as Type 1 diabetes mellitus(T1DM) and Type 2 diabetes mellitus(T2DM). Mendelian randomization analysis was performed to further evaluate the causal association between fasting plasma glucose, glycosylated hemoglobin(HbA1c),T1DM,T2DM and vitiligo.MethodsWe used aggregated genome-wide association data from the (Integrative Epidemiology Unit) IEU online database of European adults vitiligo; Glycated hemoglobin (HbA1c) data were from (IEU). Fasting blood glucose data were obtained from the European Bioinformatics Institute(EBI). T1DM and T2DM data were from FinnGen(FINN).We used bidirectional two-sample and multivariate Mendelian randomization analyses to test whether dysglycemic measures (fasting blood glucose, HbA1c), diabetes-related measures (T1DM, T2DM) are causatively associated with vitiligo. IVW method was used as the main test method, MR-Egger, Weighted mode and Weighted median were used as supplementary methods.ResultsWe found no statistically significant evidence to support a causal association between dysglycemic traits and vitiligo, but in the correlation analysis of diabetic traits, our data supported a positive causal association between T1DM and vitiligo (p=0.018; 95%OR:1.000(1.000-1.000)); In the follow-up multivariate MR Analysis, our results still supported this conclusion (p=0.016, 95% OR= 1.000(1.000-1.000)), and suggested that Hba1c was not a mediator of T1DM affecting the pathogenesis of vitiligo. No reverse causality was found in any of the reverse MR Analyses of dysglycemic traits and diabetic traits.ConclusionsOur findings support that T1DM is a risk factor for the development of vitiligo, and this conclusion may explain why the co-presentation of T1DM and vitiligo is often seen in observational studies. Clinical use of measures related to T1DM may be a new idea for the prevention or treatment of vitiligo.

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Section: Discussionmentioning

confidence: 99%

Diabetes, glycaemic profile and risk of vitiligo: a Mendelian randomisation study

Hu,

Che,

Cai

et al. 2023

Preprint

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“…CD4 + T cells play an important role in the occurrence and development of T1DM, and can mediate the destruction of pancreatic β cells, thus inducing the occurrence of type 1 diabetes 29 , 30 . The immunohistochemical results of mouse suggest that, compared with the normal group, the proportion of CD4 + T cells and macrophages in the pancreas of DM mice were significantly increased.…”

Section: Discussionmentioning

confidence: 99%

Changes of macrophage and CD4+ T cell in inflammatory response in type 1 diabetic mice

Gao

Jiang

et al. 2022

Sci Rep

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Immune cells play an important role in the development of inflammation in type 1 diabetes mellitus, so we want to explore the changes of CD4+ T cells and macrophages in vivo, which can provide an experimental basis for immunotherapy based on CD4+ T cells and macrophages. The intraperitoneal injection of streptozocin was used to induce a type 1 diabetes mellitus mouse model; the blood glucose, body weight, and the expression of inflammatory factors in the kidney were measured. Immunohistochemistry was applied to determine and analyze the infiltration of CD4+ T cells and macrophages in the spleen, pancreas, and kidney. The subtypes of macrophages in the kidney and CD4+ T cells in the spleen were analyzed by flow cytometry. Our study suggests that CD4+ T cells and macrophages increase, while the inflammatory immune response system is activated in the development of T1DM. CD4+ T cells positively correlated with macrophages in the pancreas and kidney of T1DM. CD4+ T cells turn to pro-inflammatory subtypes in the spleen of T1DM, while macrophages turn to pro-inflammatory subtypes in the kidney of T1DM. Therefore, regulation of CD4+ T cells and macrophages may be a potential target for T1DM and kidney complications.

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“…T1DM 26 is an autoimmune disease that results in the destruction of insulin-producing pancreatic beta cells. Some studies suggest that T cells and B cells play a crucial role 27 in the pathogenesis of diseases.…”

Section: Assumptions To Explain the Outcomesmentioning

confidence: 99%

Diabetes, glycemic profile and risk of vitiligo: A Mendelian randomization study

Hu,

Che,

Cai

et al. 2024

Skin Research and Technology

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BackgroudPrevious observational studies have shown that vitiligo usually co‐manifests with a variety of dysglycemic diseases, such as Type 1 diabetes mellitus (T1DM) and Type 2 diabetes mellitus (T2DM). Mendelian randomization (MR) analysis was performed to further evaluate the causal association between fasting plasma glucose, glycosylated hemoglobin (HbA1c), T1DM, T2DM and vitiligo.Materials and methodsWe used aggregated genome‐wide association data from the Integrative Epidemiology Unit (IEU) online database of European adults vitiligo; HbA1c data were from IEU. Fasting blood glucose data were obtained from the European Bioinformatics Institute (EBI). T1DM and T2DM data were from FinnGen. We used bidirectional two‐sample and multivariate MR analyses to test whether dysglycemic measures (fasting blood glucose, HbA1c), diabetes‐related measures (T1DM, T2DM) are causatively associated with vitiligo. Inverse variance weighting (IVW) method was used as the main test method, MR‐Egger, Weighted mode and Weighted median were used as supplementary methods.ResultsWe found no statistically significant evidence to support a causal association between dysglycemic traits and vitiligo, but in the correlation analysis of diabetic traits, our data supported a positive causal association between T1DM and vitiligo (p = 0.018). In the follow‐up multivariate MR analysis, our results still supported this conclusion (p = 0.016), and suggested that HbA1c was not a mediator of T1DM affecting the pathogenesis of vitiligo. No reverse causality was found in any of the reverse MR Analyses of dysglycemic traits and diabetic traits.ConclusionsOur findings support that T1DM is a risk factor for the development of vitiligo, and this conclusion may explain why the co‐presentation of T1DM and vitiligo is often seen in observational studies. Clinical use of measures related to T1DM may be a new idea for the prevention or treatment of vitiligo.

show abstract

B Quiet: Autoantigen-Specific Strategies to Silence Raucous B Lymphocytes and Halt Cross-Talk with T Cells in Type 1 Diabetes

Cited by 7 publications

References 97 publications

Diabetes, glycaemic profile and risk of vitiligo: a Mendelian randomisation study

Diabetes, glycaemic profile and risk of vitiligo: a Mendelian randomisation study

Changes of macrophage and CD4+ T cell in inflammatory response in type 1 diabetic mice

Diabetes, glycemic profile and risk of vitiligo: A Mendelian randomization study

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