<b>Outcome After Endovascular Treatment of Deep Femoral Artery Stenosis:</b>Results in a Consecutive Patient Series and Systematic Review of the Literature

Dick, Petra; Mlekusch, Wolfgang; Sabeti, Schila; Amighi, Jasmin; Schlager, Oliver; Haumer, Markus; Minar, Erich; Schillinger, Martin

doi:10.1583/05-1766r.1

Cited by 32 publications

(12 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Reductions in ankle-brachial indices (ABIs) provide a clinically useful tool for identifying symptomatic individuals at risk72, 73. Increased mobility, reduced claudication, limb salvage, and improved ABIs can often be achieved by surgical or percutaneous vascular interventions71 -- more successfully so in stenosed distal femoropopliteal segments76, 77 than proximal segments78, and less successfully so in patients with diabetes79-81. However, in the setting of T2DM, PAD arises with contributions from both medial artery calcification and atherosclerosis74.…”

Section: Inflammatory Cytokines In the Initiation And Progressionmentioning

confidence: 99%

Inflammation and the Osteogenic Regulation of Vascular Calcification

et al. 2010

View full text Add to dashboard Cite

A rterial biomineralization processes have been afflicting humans for Ն5 millennia, as realized in 2003 via the computed tomographic imaging of Ö tzi, the intriguing "ice mummy" discovered in the Tyrolean Alps. 1 Patchy abdominal atherosclerotic calcification was readily detected in the postmortem of this Ϸ40-year-old hunter of the early Copper Age, by 2000 years a predecessor of King Tutankhamen. 1 Today, an epidemic of vascular calcification is emerging within our aging and dysmetabolic populace. 2,3 Although vascular calcification was once considered only a passive process of dead and dying cells, work from laboratories worldwide has now highlighted that arterial biomineralization is an actively regulated form of calcified tissue metabolism. 4,5 Moreover, as in skeletal development -where unique biology controls matrix mineralization in membranous bone, endochondral bone, dentin, and enamel, 6,7 mechanistic diversity exists in the pathobiology of vascular calcium deposition. 2,4,5,8 Five common forms of vascular calcification, each possessing unique histoanatomic characteristics and clinical settings with overlapping yet distinct molecular mechanisms, have been described to date 4,5,9 (Table 1). Although we touch on the subject, the reader is referred to other contemporary reviews for in-depth consideration of pathogenic differences. 2,4,5 In this brief review and perspective, we recount recent data that emphasize inflammation and oxidative stress signaling as key contributors to the pathogenesis of vascular mineral deposition. 10 Furthermore, we highlight differences between the low-density lipoprotein receptor (LDLR)-deficient and apolipoprotein E (apoE)-deficient murine models ( Table 2) that help articulate the multifaceted contributions of dyslipidemia, diabetes mellitus, and uremia to arterial calcium deposition. 2,4,11 We end by summarizing the importance of considering these disease stage-and context-specific contributions arterial mineralization when crafting therapeutic strategies to address the disease burden of vascular calcification that increasingly afflicts our patients. 5 28 -32 In this section, we review this new data and also highlight distinctions between the LDLR Ϫ/Ϫ and apoE Ϫ/Ϫ murine disease models 33 ( Table 2) that provide insights into the mechanistic complexities of inflammation-dependent arterial calcium accumulation. RANKL and Atherosclerotic CalcificationReceptor Activator of Nuclear Factor B Ligand/ Osteoprotegerin Signaling and Atherosclerotic Calcification The first robust evidence for the primary contributions of inflammatory cytokine signaling to pathogenesis of vascular calcification arose from the generation and evaluation of the osteoprotegerin (OPG) Ϫ/Ϫ mouse. 34 OPG-deficient mice develop severe medial and intimal arterial calcification in conjunction with high-turnover osteoporosis driven by excessive osteoclast formation. 34 OPG was first shown to function as an antagonistic "faux receptor" of receptor activator of nuclear factor B ligand (RANKL), the TNF superfamil...

show abstract

Section: Inflammatory Cytokines In the Initiation And Progressionmentioning

confidence: 99%

Inflammation and the Osteogenic Regulation of Vascular Calcification

et al. 2010

View full text Add to dashboard Cite

show abstract

“…These findings are consistent with those in 4 contemporary series from North America and Western Europe, with a total of 121 patients (123 limbs) reporting a technical success rate of 93% (114 of 123 limbs) and an amputation rate at 1 year ranging from 3.6% to 36%. 9,[11][12][13] Open surgical profundaplasty has long been recognized as a method of limb salvage in patients with CLI secondary to severe femoral and popliteal artery occlusive disease and who are deemed unsuitable for a femoral-distal bypass due to extensive comorbidities or lower limb integmenta necrosis/infection. Rollins et al and Savolainen et al report the two largest case series in the English literature.…”

Section: Discussionmentioning

confidence: 99%

“…The largest study to date by Dick et al reports perioperative complications occurring in 1.8% of the patients with no cases of wound infection, seroma formation, or early mortality following 55 ePFRs. 12 Diehm et al compared ePFR and surgical profundaplasty and reported no perioperative complications or mortality in the ePFR cohort, whereas the surgical profundaplasty cohort demonstrated an in-hospital mortality of 29%. 13 This study was limited by the small number (n ¼ 20) of patients.…”

Section: Discussionmentioning

confidence: 99%

Isolated Percutaneous Transluminal Angioplasty of the Profunda Femoris Artery for Limb Ischemia

Davies

Rashid

Adair

et al. 2013

Vasc Endovascular Surg

View full text Add to dashboard Cite

show abstract

“…As in other vascular beds, there are many different endovascular options available for the treatment of a stenotic diseased femoral bifurcation. Simple single‐balloon PTA is the first option for both DFA and CFA lesions [4, 9–21]. As dilation of ostial DFA or SFA lesions with single balloons can cause dissection or shifting of the plaque and can lead to an occlusion of the other vessel, the kissing balloon technique might be preferred [22].…”

Section: Endovascular Approachmentioning

confidence: 99%

“…The retrospective studies report procedural success rates ranging from 77 to 100%. Follow‐up results are often lacking and if available difficult to compare due to the variety in reported patency definitions and follow‐up times (Table I) [4, 9–18, 20, 21].…”

Section: Endovascular Approachmentioning

confidence: 99%

Femoral bifurcation disease: Balloon or knife

Bosiers

Deloose

2009

Cathet Cardio Intervent

View full text Add to dashboard Cite

Arterial occlusive disease at the level of the femoral bifurcation mostly occurs in combination with inflow and/or outflow lesions. Surgical endarterectomy of the femoral bifurcation is a well-proven low-risk and easy surgical intervention with known durable success, while, although proven to be safe, evidence is lacking about the durability of the endovascular approach. Based on the evidence at hand, the surgical approach should be recommended for the vast majority of patients and the endovascular approach should only be indicated as the first strategy in selected cases presenting with factors that might compromise the outcome of surgery in the groin. If feasible, the hybrid approach with endarterectomy at the level of the bifurcation and endovascular repair of the inflow and outflow lesions is preferred in patients with multilevel disease.

show abstract

Outcome After Endovascular Treatment of Deep Femoral Artery Stenosis:Results in a Consecutive Patient Series and Systematic Review of the Literature

Cited by 32 publications

References 20 publications

Inflammation and the Osteogenic Regulation of Vascular Calcification

Inflammation and the Osteogenic Regulation of Vascular Calcification

Isolated Percutaneous Transluminal Angioplasty of the Profunda Femoris Artery for Limb Ischemia

Femoral bifurcation disease: Balloon or knife

Contact Info

Product

Resources

About