<b>Microscopic, lymphocytic and collagenous colitis</b>

Jawhari, Aida; Talbot, Ian C.

doi:10.1046/j.1365-2559.1996.d01-498.x

Cited by 87 publications

(51 citation statements)

References 36 publications

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“…Unlike CC, LC affects males and females equally (1). CC and LC should be considered to be separate but similar conditions, although conversion of LC to CC has been described in a few cases (1,2).…”

Section: Small Bowel Biopsymentioning

confidence: 99%

Prevalence of Celiac Disease in Collagenous and Lymphocytic Colitis

Gillett

Freeman

2000

Canadian Journal of Gastroenterology and Hepatology

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Both collagenous and lymphocytic colitis have been described in patients with celiac disease, suggesting an association between the conditions. Over the past few years, the availability, sensitivity and specificity of serological markers for celiac disease have improved - the most recent advancement being the description of tissue transglutaminase as the major antigen for endomysium antibody. A quantitative ELISA was used to measure titres of immunoglobulin A (IgA) antibody to tissue transglutaminase (tTG) along with an immunofluorescent technique for IgA endomysium antibody (EmA) in 15 patients with lymphocytic colitis and eight with collagenous colitis to determine whether celiac disease latency could be detected. One patient with lymphocytic colitis demonstrated both elevated titres of tTG antibody and positive EmA, and small bowel biopsy confirmed celiac disease. One patient with collagenous colitis had a slightly elevated titre of tTG antibody with a negative EmA, and results of a small bowel biopsy were normal. Three other patients with lymphocytic colitis were already treated for previously diagnosed celiac disease. The prevalence of celiac disease occurring in lymphocytic colitis was found to be 27%, but no cases of celiac disease in association with collagenous colitis were found.

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Section: Small Bowel Biopsymentioning

confidence: 99%

Prevalence of Celiac Disease in Collagenous and Lymphocytic Colitis

Gillett

Freeman

2000

Canadian Journal of Gastroenterology and Hepatology

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“…Lymphocytic colitis (1)(2)(3)(4) and collagenous colitis (1,(3)(4)(5)(6)(7) consist of a spectrum of related clinicopathological entities. Collagenous colitis primarily affects middle-aged and older women, who present with prolonged watery diarrhea.…”

mentioning

confidence: 99%

“…Evidence of chronic mucosal injury, such as crypt distortion and architectural disarray, is generally lacking (9). However, subepithelial collagen thickening is seen only in collagenous colitis (1,(3)(4)(5)(6)(7).…”

mentioning

confidence: 99%

Histopathological Features of the Terminal Ileum in Lymphocytic and Collagenous Colitis: A Study of 32 Cases and Review of Literature

Padmanabhan

Callas

et al. 2003

Modern Pathology

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Biopsy specimens from the terminal ileum of 32 patients with the histopathological diagnosis of lymphocytic colitis or collagenous colitis and 11 control individuals were evaluated for the presence or absence of ileal mucosal abnormalities and for the number of intraepithelial lymphocytes, assessed by immunohistochemical stains for the pan T-cell marker, CD3. We found that the mean CD3 counts in patients with lymphocytic/collagenous colitis were significantly higher than those in the control group. Seven of 14 patients with collagenous colitis and 14 of 18 patients with lymphocytic colitis revealed an increase in intraepithelial T lymphocytes when compared with the control group (P ‫؍‬ .001). Other notable changes included ileal villous atrophy in one case of lymphocytic colitis and in three cases of collagenous colitis and epithelial damage with thickened subepithelial collagen in two cases of collagenous colitis.

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“…The number of IELs, assessed in five consecutive crypts, showed a mean of 39 IELs/100 cryptal epithelial cells (range, 33-43). In contrast, the mean number of IELs recorded in the surface columnar cells was 8/100 surface columnar cells (range, [1][2][3][4][5][6][7][8][9][10][11][12][13][14].…”

Section: Patientmentioning

confidence: 99%

“…In recent years, the number of published reports on lymphocytic colitis has increased rapidly, [4][5][6][7] reflecting the increased histological detection of the disease.…”

mentioning

confidence: 99%