B lymphocytes in renal interstitial fibrosis

Zhu, Fengge; Bai, Xueyuan; Chen, Xiangmei

doi:10.1007/s12079-017-0382-x

Cited by 9 publications

(5 citation statements)

References 54 publications

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“…Within the FBGs, CD20 + B cells were rare at about 5%, which is in agreement with several studies [ 4 , 23 , 27 ], but interestingly dense clusters were frequently found near the FBGs accumulated around blood vessels. This finding may gain importance by the fact that B cells influence T cell responses and affect fibrosis through interactions with other cells including fibroblasts and macrophages [ 28 ]. Furthermore, proliferation of B cells in extramedullary environments allows for survival of self-reactive B cells, thereby increasing the potential for autoimmune pathology [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Characterization of innate and adaptive immune cells involved in the foreign body reaction to polypropylene meshes in the human abdomen

Dievernich

Achenbach

Klinge

2021

Hernia

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Background Polypropylene (PP) mesh is widely used to reinforce tissues. The foreign body reaction (FBR) to the implant is dominated by innate immune cells, especially macrophages. However, considerable numbers of adaptive immune cells, namely T cells, have also been regularly observed, which appear to play a crucial role in the long-term host response. Methods This study investigated the FBR to seven human PP meshes, which were removed from the abdomen for recurrence after a median of one year. Using immunofluorescence microscopy, the FBR was examined for various innate (CD11b+ myeloid, CD68+ macrophages, CD56+ NK) and adaptive immune cells (CD3+ T, CD4+ T-helper, CD8+ cytotoxic, FoxP3+ T-regulatory, CD20+ B) as well as “conventional” immune cells (defined as cells expressing their specific immune cell marker without co-expressing CD68). Results T-helper cells (19%) and regulatory T-cells (25%) were present at comparable rates to macrophages, and clustered significantly toward the mesh fibers. For all cell types the lowest proportions of “conventional” cells (< 60%) were observed at the mesh–tissue interface, but increased considerably at about 50–100 µm, indicating reduced stimulation with rising distance to the mesh fibers. Conclusion Both innate and adaptive immune cells participate in the chronic FBR to PP meshes with T cells and macrophages being the predominant cell types, respectively. In concordance with the previous data, many cells presented a “hybrid” pattern near the mesh fibers. The complexity of the immune reaction seen within the foreign body granuloma may explain why approaches focusing on specific cell types have not been very successful in reducing the chronic FBR.

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Section: Discussionmentioning

confidence: 99%

Characterization of innate and adaptive immune cells involved in the foreign body reaction to polypropylene meshes in the human abdomen

Dievernich

Achenbach

Klinge

2021

Hernia

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“…The recruitment and activation of inflammatory cells, such as macrophages and lymphocytes, are the major events that mediate the onset of renal fibrogenesis. Macrophages and lymphocytes can produce multiple cytokines and chemokines, which results in the recruitment of monocyte amplifying the inflammatory responses . Additionally, the degree of inflammatory cell infiltration is closely related to the extent of renal fibrosis, thereby suppressing the recruitment of inflammatory cells that could attenuate renal fibrosis .…”

Section: Discussionmentioning

confidence: 99%

Cryptotanshinone Attenuates Oxidative Stress and Inflammation through the Regulation of Nrf‐2 and NF‐κB in Mice with Unilateral Ureteral Obstruction

Wang

Zhang

et al. 2018

Basic Clin Pharma Tox

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Oxidative stress and inflammatory responses are closely implicated in the progression of renal interstitial fibrosis, thereby leading to chronic kidney disease. Cryptotanshinone (CTS) is a natural compound involved in antioxidant and anti-inflammatory activities. We evaluated the effects of CTS on inflammation and oxidative stress in obstructed kidneys. Mice received gastric gavage of CTS from 7 days before unilateral ureteral obstruction operation to 1 week after surgery. Administration of CTS at 50 and 100 mg/kg/day significantly decreased collagen production, as shown by Masson staining. Immunohistochemistry staining and RT-PCR confirmed that CTS reduced extracellular matrix proteins, such as fibronectin and collagen-1, in the obstructed kidneys in a dose-dependent manner. Furthermore, immunohistochemistry staining indicated that CTS inhibited infiltration of the macrophage (CD68-positive) and lymphocyte (CD3-positive) cells, which were associated with the suppression of the nuclear factor-κB signalling activation. CTS increased superoxide dismutase, catalase and glutathione while decreased malondialdehyde production. More importantly, CTS activated Nrf-2 and HO-1 in the obstructed kidneys for 7 days. CTS could protect renal interstitial fibrosis by ameliorating inflammation and oxidative stress, which might be through the regulation of NF-κB and Nrf-2/HO-1 signalling pathways.

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“…Yet, very few in vivo studies have been published elucidating the relationship between lymphocytes and FBR. Previously implicated in wound healing [92][93][94] and fibrosis [95][96][97][98][99], B cells have been investigated for their contribution to the FBR towards synthetic materials in animal models. Specifically, in a recent study, after 6 weeks following intramuscular implantation of PCL particulates into muMt -(B cell knockout (KO)) mice, collagen matrix deposition as well as expression of fibrosis-associated inflammatory genes for S100a4, Col1a1, Col3a1, TGF-β, p21, and IL-23 significantly decreased [83].…”

Section: Animal Models and The Fbrmentioning

confidence: 99%

Foreign body response to synthetic polymer biomaterials and the role of adaptive immunity

et al. 2022

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Implanted biomaterials elicit a series of distinct immune and repair-like responses that are collectively known as the foreign body reaction (FBR). These include processes involving innate immune inflammatory cells and wound repair cells that contribute to the encapsulation of biomaterials with a dense collagenous and largely avascular capsule. Numerous studies have shown that the early phase is dominated by macrophages that fuse to form foreign body giant cells that are considered a hallmark of the FBR. With the advent of more precise cell characterization techniques, specific macrophage subsets have been identified and linked to more or less favorable outcomes. Moreover, studies comparing synthetic- and natural-based polymer biomaterials have allowed the identification of macrophage subtypes that distinguish between fibrotic and regenerative responses. More recently, cells associated with adaptive immunity have been shown to participate in the FBR to synthetic polymers. This suggests the existence of cross-talk between innate and adaptive immune cells that depends on the nature of the implants. However, the exact participation of adaptive immune cells, such as T and B cells, remains unclear. In fact, contradictory studies suggest either the independence or dependence of the FBR on these cells. Here, we review the evidence for the involvement of adaptive immunity in the FBR to synthetic polymers with a focus on cellular and molecular components. In addition, we examine the possibility that such biomaterials induce specific antibody responses resulting in the engagement of adaptive immune cells.

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B lymphocytes in renal interstitial fibrosis

Cited by 9 publications

References 54 publications

Characterization of innate and adaptive immune cells involved in the foreign body reaction to polypropylene meshes in the human abdomen

Characterization of innate and adaptive immune cells involved in the foreign body reaction to polypropylene meshes in the human abdomen

Cryptotanshinone Attenuates Oxidative Stress and Inflammation through the Regulation of Nrf‐2 and NF‐κB in Mice with Unilateral Ureteral Obstruction

Foreign body response to synthetic polymer biomaterials and the role of adaptive immunity

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