<b>FHtest</b>: An <i>R</i> Package for the Comparison of Survival Curves with Censored Data

Oller, Ramón; Langohr, Klaus

doi:10.18637/jss.v081.i15

Cited by 16 publications

(12 citation statements)

References 19 publications

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“…The log 2 RPKM of the 8 genes selected from GSEA were calculated and summed up as a combined score for CD8 + T cell functionality. To test whether this score was associated with better survival in the 42 patients, we used the R package ''FHtest'' to perform a one-sided FH-test on its effect on the one-year survival rate (Oller and Langohr, 2017).…”

Section: Super-enhancer Erna Expression Profilesmentioning

confidence: 99%

A High-Resolution Map of Human Enhancer RNA Loci Characterizes Super-enhancer Activities in Cancer

Chen

Liang

2020

Cancer Cell

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Section: Super-enhancer Erna Expression Profilesmentioning

confidence: 99%

A High-Resolution Map of Human Enhancer RNA Loci Characterizes Super-enhancer Activities in Cancer

Chen

Liang

2020

Cancer Cell

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“…Stratification was done by whether epinephrine was administered before or after the airway was attempted and tested via the Fleming-Harrington test for interval censored data via permutations. 17 To account for potential confounding, we used multivariable Cox regression, adjusting for: age (continuous); sex (male, female, unknown), first recorded EMS rhythm grouped as ventricular fibrillation (VF)/ventricular tachycardia (VT)/shockable by automated external defibrillator, pulseless electrical activity (PEA), asystole, no shock, and no strip (cannot determine); witness status (EMS, bystander, none, unknown); bystander CPR status (no CPR, CPR but no automated external defibrillator (AED), CPR and AED); dispatch to arrival time (continuous); arrest location (public, private); ALS first arrival (yes, no); successful intravenous (IV) or intraosseous (IO) access (neither, IV only, IO only, both); and epinephrine before airway (yes, no). Patients who received no epinephrine were coded as having airway placement before epinephrine administration.…”

Section: Discussionmentioning

confidence: 99%

Effect of initial airway strategy on time to epinephrine administration in patients with out-of-hospital cardiac arrest

et al. 2019

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Introduction: Epinephrine and advanced airway management are commonly used during treatment of out-of-hospital cardiac arrest (OHCA). Recent studies suggest that early but not late administration of epinephrine is associated with improved survival. The purpose of this study was to evaluate the effect of initial airway strategy on timing to the first epinephrine dose in OHCA. Methods: This is a secondary analysis of patients enrolled in the Pragmatic Airway Resuscitation Trial who had an advanced airway attempted. We examined differences in time to epinephrine administration by randomly assigned airway strategy, laryngeal tube (LT) or endotracheal tube (ETI); by the duration of airway attempt; and by number of attempts. We used survival methods to account for interval censoring due to unknown administration time. We also examined the association of epinephrine administration timing with survival to hospital discharge. Results: Among 2652 subjects (1299 ETI and 1353 LT), 2579 received epinephrine. There were no significant differences between ETI and LT in median time to initial epinephrine administration (min) (ETI-9.0 vs. LT-8.6, p=0.55). There was no significant association between the duration of airway attempt or number of attempts and time to initial epinephrine administration (p=0.12 and 0.66, respectively). Early administration of epinephrine (<10 minutes from EMS arrival) was significantly associated with survival compared to administration ≥10 minutes (OR 1.36, 95% CI: 1.05, 1.77). Conclusions: There was no significant association between airway strategy and time to initial epinephrine administration. Earlier administration of epinephrine (< 10 minutes from EMS arrival) was associated with improved survival.

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“…For the analysis of the interval-censored data, we used the Turnbull estimator to estimate the probability that the LoQ was reached as a function of time ( Turnbull, 1976 ). The generalized log-rank test for interval-censored data based on a vector distribution was used to test whether the median times until the LoQ differ among feeding trajectories ( Fay and Shaw, 2010 ; Oller and Langohr, 2017 ).…”

Section: Methodsmentioning

confidence: 99%

Neonatal Feeding Trajectories in Mothers With Bipolar Disorder Taking Lithium: Pharmacokinetic Data

et al. 2021

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Purpose: Women who take lithium during pregnancy and continue after delivery may choose to breastfeed, formula feed, or mix these options. The aim of the study was to evaluate the neonatal lithium serum concentrations based on these three feeding trajectories.Methods: We followed 24 women with bipolar disorder treated with lithium monotherapy during late pregnancy and postpartum (8 per trajectory). Lithium serum concentrations were determined by an AVL 9180 electrolyte analyser with a 0.10 mEq/L detection limit and a 0.20 mEq/L limit of quantification (LoQ).Results: There was complete lithium placental passage at delivery, with a mean ratio of lithium concentration in the umbilical cord to maternal serum of 1.12 ± 0.17. The median times to LoQ were 6–8, 7–8, and 53–60 days for formula, mixed, and exclusive breastfeeding respectively. The generalized log-rank testing indicated that the median times to LoQ differ according to feeding trajectory (p = 0.037). According to the multivariate analysis-adjusted lithium serum concentrations at birth, times to LoQ are, on average, longer under exclusive breastfeeding (formula, p = 0.015; mixed, p = 0.012). No lithium accumulation was observed in infants under either exclusive or mixed breastfeeding. During the lactation follow-up, there was no acute growth or developmental delays in any neonate or infant. Indeed, lithium concentrations in the three trajectories declined in all cases. However, the time needed to reach the LoQ was much longer for those breastfeeding exclusively.Conclusions: In breastfeed infant no sustained accumulation of lithium and no adverse effects on development or growth were observed.

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FHtest: An R Package for the Comparison of Survival Curves with Censored Data

Cited by 16 publications

References 19 publications

A High-Resolution Map of Human Enhancer RNA Loci Characterizes Super-enhancer Activities in Cancer

A High-Resolution Map of Human Enhancer RNA Loci Characterizes Super-enhancer Activities in Cancer

Effect of initial airway strategy on time to epinephrine administration in patients with out-of-hospital cardiac arrest

Neonatal Feeding Trajectories in Mothers With Bipolar Disorder Taking Lithium: Pharmacokinetic Data

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