<b>Evaluation of cannibalistic cells: a novel entity in prediction of aggressive nature of oral squamous cell carcinoma</b>

Jose, Deepa; Mane, Deepa; Datar, Uma Vasant; Muttagi, Sidramesh; Hallikerimath, Seema; Kale, Alka D

doi:10.3109/00016357.2013.798872

Cited by 18 publications

(26 citation statements)

References 17 publications

(9 reference statements)

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“…CC has been frequently observed in vivo in seve ral benign and malignant tumors including breast carcinoma [8], giant cell carcinoma of lung [9], endometrial stromal sarcoma [10], malignant melanoma [11], gastric adenocarcinoma [12], giant-cell tumor of the tendon sheath [4], lung carcinoma, gall bladder carcinoma [13], giant cell granuloma of the oral cavity [14], salivary duct carcinoma [15], oral squamous cell carcinoma (OSCC) [16][17][18][19]. These tumor cells cannibalize their siblings as well as cells from the immune system in order to sustain and defend existing unfavorable conditions within the microenvironment such as hypoxia, lack of nutrition and acidity.…”

Section: Cellular Cannibalism and Cancermentioning

confidence: 99%

“…Jose et al [18] evaluated 20 neck dissection cases of OSCC and found statistically significant correlation between advanced grade of CC and positive lymph node metastasis. So, the authors concluded that CC can be considered as one of the important parameter to assess an aggressive nature of OSCC.…”

Section: Cellular Cannibalism As a Prognosticator Of Oral Squamous Cementioning

confidence: 99%

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An Overview on “Cellular Cannibalism” With Special Reference to Oral Squamous Cell Carcinoma

Jain¹

2015

Exp. Onc.

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Cellular cannibalism has been defined as a large cell engulfing a slightly smaller one within its cytoplasm. It has been described in various cancers like bladder cancer, breast cancer, lung cancer, gastric cancer, oral squamous cell carcinoma. Cellular cannibalism has been well correlated with anaplasia, tumor aggressiveness, grading and metastatic potential. Present review focuses on significance of cannibalism in relation to cancer with special emphasis on oral squamous cell carcinoma.

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Section: Cellular Cannibalism and Cancermentioning

confidence: 99%

Section: Cellular Cannibalism As a Prognosticator Of Oral Squamous Cementioning

confidence: 99%

An Overview on “Cellular Cannibalism” With Special Reference to Oral Squamous Cell Carcinoma

Jain¹

2015

Exp. Onc.

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“…Various methodologies have been used for grading EK in various tumors. Especially in OSCC, Jose et al 13 The EK ranged from 1 to 10 with mean of 4.125 + 2.107. The phenomenon of complex endocytosis was observed in 9 (16.07%) cases.…”

Section: Discussionmentioning

confidence: 98%

Endocytosis of keratinocytes in oral squamous cell carcinoma

Sarode

Kulkarni

et al. 2016

Translational Research in Oral Oncology

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Objectives: To quantify endocytosis of keratinocytes (EK) in oral squamous cell carcinoma (OSCC) and correlate it with different clinical and histopathological parameters. Further, the expression of cluster of differentiation 68 (CD68) and lysozyme was studied in tumor cells to corroborate this phenomenon. Materials and method: EK per high-power field (HPF) was calculated on hematoxylin and eosin-stained sections and correlated with clinical and histopathological parameters. CD68 and lysozyme were studied in tumor cells using immunohistochemistry. Results: The mean EK per HPF was higher in stage IV (4.450 + 2.241) than stage III (3.333 + 1.543) OSCC (p ¼ 0.1978). Although there were more EK in N2 stage (4.362 + 0.3405) as compared to N0-N1 (3.462 + 0.4178), the results were statistically insignificant. Statistically significant difference in mean EK was observed in all the grades of OSCC: well versus moderate (p ¼ 0.0052), moderate versus poor (p < 0.0001), and well versus poor (p ¼ 0.0001). There were significant differences in the mean EK (p < 0.05) between different grades of stromal degenerations (mild: 2.654 + 1.093, moderate: 5.115 + 1.774, and severe: 7.250 + 2.217). Statistically significant differences were observed in CD68 expression in tumor cells of various TNM stages (p ¼ 0.049), histopathological grades (p ¼ 0.045), and stromal degeneration (p ¼ 0.024). Likewise, lysozyme expression in tumor cells was also statistically significant in histopathological grades (p ¼ 0.004) and mean EK value (p ¼ 0.0119). Conclusion: The mean EK in OSCC increases with increasing histopathological grades, TNM stages, and stromal degeneration. CD68 and lysozyme can be used as markers of EK in OSCC.

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“…Thus, for the management of a lesion, histopathologic parameters must be considered in hematoxylin and eosin staining of specimens, and more attention must be paid to cellular and histological aspects. 3 CC is among these parameters, and can be observed under a light microscope without requiring any advanced molecular technique. 1,3,4 The presence of CC has not been previously reported in LP.…”

mentioning

confidence: 99%

“…3 CC is among these parameters, and can be observed under a light microscope without requiring any advanced molecular technique. 1,3,4 The presence of CC has not been previously reported in LP. However, it can be identified in LP specimens with careful inspection (Figure 1…”

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confidence: 99%

Cellular cannibalism and lichen planus malignancy: A suggestive hypothesis

Zargaran

2018

J of Invest & Clin Dent

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I read the article by Sarode and colleagues entitled "Cellular cannibalism in giant cells of central giant cell granuloma of jaw bones and giant cell tumors of long bones" 1 in the Journal of Investigative and Clinical Dentistry and was interested in cellular cannibalism, and thought of its potential useful applications, particularly association to lichen planus malignancy. Cellular cannibalism (CC) is referred to as a phenomenon, in which a large tumoral cell engulfs a smaller tumoral cell in its cytoplasm. 2 This creates an unusual appearance of a complete cell with a semilunar nucleus that has swallowed a smaller cell with a round-to-oval nucleus. 3 This phenomenon is different from phagocytosis, because cannibalism cells exclusively digest viable cells. 2 Internalized cells are viable when swallowed, but this process results in their death. They are eventually degraded, 2 and show an apoptotic appearance with lost nucleus and increased cytoplasmic density. 1 CC has been described as a morphologic pattern of malignancy, 4 and it has been reported in many malignant tumors, especially aggressive malignancies. 3,4 It also has a significant correlation with anaplasia, invasiveness, and malignant metastatic potential, and can promote tumor progression. 4 Lichen planus (LP) is an immune-mediated, chronic inflammatory disorder affecting the skin and/or mucus membranes, and has variable clinical manifestations. LP is considered a premalignant LETTER TO THE EDITOR internalized cells impair the cytokinesis of cells that swallowed them and promote tumor growth by this mechanism and the development of aneuploidy 4 c) Carcinogenesis can occur in acidic microenvironments. The acidity of the microenvironment of the lesion plays an important role in the formation of CC, because these cells are particularly resistant to low pH and can tolerate such toxic environments and survive unfavorable conditions 1,3 d) Aside from the swallowing of tumoral cells by CC, 2 recent reports indicate swallowing of other cells, such as immune cells, as well.Thus, the lesion can use CC as an escape mechanism from the immune system. 2,3 With this process, cells with chromosomal instability can be protected from eradication This hypothesis requires further study, which could facilitate the screening and early detection of patients at risk. The presence of CC, especially the increasing number of such cells in LP, might be a potential cause of alarm to launch accurate assessment and continue follow up of LP patients by clinicians. ORCID Massoumeh Zargaran

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Evaluation of cannibalistic cells: a novel entity in prediction of aggressive nature of oral squamous cell carcinoma

Abstract: Interestingly the cases with positive lymph node metastasis demonstrated Grade 3 CC.Hence, during routine histopathological examination, the search of CC can be considered as one of the important parameters to note the aggressive nature of OSCC.

Cited by 18 publications

References 17 publications

An Overview on “Cellular Cannibalism” With Special Reference to Oral Squamous Cell Carcinoma

An Overview on “Cellular Cannibalism” With Special Reference to Oral Squamous Cell Carcinoma

Endocytosis of keratinocytes in oral squamous cell carcinoma

Cellular cannibalism and lichen planus malignancy: A suggestive hypothesis

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