<b>Corrole Nanoparticles for Chemotherapy of Castration-Resistant Prostate Cancer and as Sonodynamic Agents for Pancreatic Cancer Treatment</b>

Soll, Matan; Sharma, Vinay K.; Khoury, Sally; Assaraf, Yehuda G.; Gross, Zeev

doi:10.1021/acs.jmedchem.2c01662

Cited by 4 publications

(3 citation statements)

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“…This was accompanied by the targeted induction of tumor cell necrosis through plasma membrane destabilization; the impairment of calcium homeostasis, lysosomal stress, and rupture; and the formation of reactive oxygen species (ROS). The in vivo relevance was addressed by using such NPs for the chemotherapy of castration-resistant prostate cancer as well as for much more difficult to treat pancreatic cancer . Chemotherapy was insufficient in the latter case, but this was resolved via sonodynamic therapy (SDT), taking advantage of earlier research that exposed corroles as potential agents for inducing the formation of singlet oxygen via sonication …”

Section: Catalytic Properties Of Metallocorroles Of Relevance To Drug...mentioning

confidence: 99%

“…The in vivo relevance was addressed by using such NPs for the chemotherapy of castration-resistant prostate cancer as well as for much more difficult to treat pancreatic cancer. 103 Chemotherapy was insufficient in the latter case, but this was resolved via sonodynamic therapy (SDT), taking advantage of earlier research that exposed corroles as potential agents for inducing the formation of singlet oxygen via sonication. 104 While the anticancer research focuses mainly on corroles chelating post-transition-metal ions such as gallium, the iron and somewhat less so manganese corroles are very relevant for a very different medicine-relevant feature: the ability to rescue rather than damage cells.…”

Section: Catalytic Properties Of Metallocorroles Of Relevance To Drug...mentioning

confidence: 99%

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Milestones and Most Recent Advances in Corrole’s Science and Technology

Mahammed

Gross

2023

J. Am. Chem. Soc.

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The renaissance in corrole chemistry is strongly correlated with synthetic breakthroughs that started in 1999, regarding the one-pot rather than multistep syntheses of this heme-like N4 macrocycle. This largely improved synthetic accessibility allowed for technological advances wherein the corresponding metal complexes have since been introduced as key elements. Great emphasis was devoted to the elucidation of the unique fundamental features that distinguish corrole ligands, among them outstanding electron donation (σ by the N atoms and π by the macrocycle) to transition metals chelated by them. Such investigations remain crucial for enabling the by-demand tuning of metallocorrole properties for distinctly different applications. These range from the catalysis of organic reactions, through bioimaging and disease prevention/treatment strategies, to photo- and electrocatalysis for clean energy. Surveyed are the original reports that impacted these developments, together with some of the most recent advances.

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Section: Catalytic Properties Of Metallocorroles Of Relevance To Drug...mentioning

confidence: 99%

Section: Catalytic Properties Of Metallocorroles Of Relevance To Drug...mentioning

confidence: 99%

Milestones and Most Recent Advances in Corrole’s Science and Technology

Mahammed

Gross

2023

J. Am. Chem. Soc.

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“…However, there is no general agreement of such a mechanism, and in most cases, singlet oxygen has been observed as the main contributors among all other types of reactive oxygen species (ROS) . In most of the applications, molecular sonosensitizers are combined with microbubbles or other sonosensitizer nanoparticles to enhance the therapeutic performance. − …”

Section: Introductionmentioning

confidence: 99%

Molecular Sonosensitizer-Loaded Polymer Nanomicelle for Ultrasound-Based Cell Therapy via Singlet Oxygen Generation

Sarkar,

Jana

2023

ACS Appl. Nano Mater.

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Ultrasound-based sonodynamic therapy has great potential for the wireless treatment of human diseases that exploit sound-responsive materials such as microbubbles, piezoelectric nanoparticles, and molecular sonosensitizers. Although small molecule-based sonosensitizers are attractive, their performance needs significant improvement, and a clear understanding of the origin of the ultrasound-mediated reactive oxygen species (ROS) generation property is yet to be established. Here, we have investigated molecular sonosensitizer-loaded poly(ethylene glycol)–poly(lactide) (PEG–PLA) micelles to investigate their ROS generation performance in the presence of ultrasound. We found that molecular sonosensitizers produce singlet oxygen as the primary ROS component, and the ROS generation performance depends on the molecular structure and experimental conditions. We propose that sonoluminescence-induced molecular excitation is associated with such ROS generation. The nanocarrier-based cell delivery of a molecular sonosensitizer is shown to generate intracellular ROS under ultrasound exposure and has been used for cell therapy application. This work shows that singlet oxygen is primarily responsible for molecular sonosensitizer-based sonodynamic therapy, and a nanomicelle-based carrier can greatly improve this therapeutic performance.

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