<b>Circulating inhibins and activin A during GnRH‐analogue down‐regulation and ovarian hyperstimulation with recombinant FSH for in‐vitro fertilization‐embryo transfer</b>

Lockwood, Gillian; Muttukrishna, Shanthi; Groome, Nigel P.; Knight, P. G.; Ledger, William

doi:10.1046/j.1365-2265.1996.8510861.x

Cited by 79 publications

(30 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This pattern indicates that there may be a close correlation between FSH and activin A. This observation is in contrast to our ®nding that activin A levels fell due to the short FSH pulses during GnRH stimulation, and the observation of Lockwood et al (28) that activin A levels remained unchanged in conjunction with the fall of FSH levels when long-term GnRH analogues were administrated to downregulate the hypophysis. This suggests that the production of activin A is not regulated by FSH.…”

Section: Discussioncontrasting

confidence: 56%

“…Moreover, our investigation of the response of pro alpha-C to GnRH downregulation produced different results than those described in the Lockwood et al study (28). Before stimulation with recombinant FSH for in vitro fertilization (IVF) Lockwood et al (28) measured unaltered pro alpha-C concentrations after pituitary downregulation with GnRH.…”

Section: Discussioncontrasting

confidence: 45%

“…This regimen of pituitary downregulation creates a hormonal milieu that speci®cally allows the impact of high doses of FSH on ovarian inhibin secretion to be elucidated. In the Lockwood et al (28) study, women with normal ovarian function participating in such IVF treatment protocols exhibited signi®cantly suppressed levels of both inhibin A and inhibin B during pituitary desensitization. During stimulation with FSH, levels of both inhibins rose markedly, whereas levels of pro alpha-C were largely unaltered and showed a signi®cant gonadotropinindependent component during IVF treatment.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Inverse correlation between baseline inhibin B and FSH after stimulation with GnRH: a study of serum levels of inhibin A and B, pro alpha-C and activin A in women with ovulatory disturbances before and after stimulation with GnRH

Casper

Seufert²,

Pollow³

2000

European Journal of Endocrinology

View full text Add to dashboard Cite

Objective: Interest has focused recently on the in¯uences of the polypeptide factors inhibin and activin on the selective regulation of the pituitary secretion of gonadotropins. Design: Measurement of the concentrations of inhibin-related proteins in relation to the changes in pituitary gonadotropin (FSH, LH) parameters, after GnRH stimulation with a bolus injection of 100 mg gonadorelin, in 19 women with ovulatory disturbances. Methods: Serum levels of inhibin A and B, activin A, and pro alpha-C were measured using sensitive ELISA kits. Results: Within 60 min after GnRH stimulation, FSH values doubled from 5 to 10 mU/ml (P < 0.001). LH increased 12-fold from 2 to 24 mU/ml (P < 0.001). Activin A showed a signi®cant decrease from 0.47 to 0.36 ng/ml (P < 0.001), whereas pro alpha-C increased from 127 to 156 pg/ml (P 0.039). The median inhibin A concentration did not show a signi®cant change between baseline and the 60 min value, whereas inhibin B was characterized by a minor, but not signi®cant, increase in the median from 168 to 179 pg/ml (P 0.408). A signi®cant inverse correlation (P 0.014) with a mean coef®cient of correlation of 0.5516 was found, demonstrating a strong relationship between high inhibin B baseline levels and a small increase of FSH after 60 min. Conclusion: Our results show an interesting correlation between the baseline inhibin B and the change in FSH before and after GnRH stimulation. A high baseline inhibin B implies only a minor increase of FSH after 60 min.

show abstract

Section: Discussioncontrasting

confidence: 56%

Section: Discussioncontrasting

confidence: 45%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Inverse correlation between baseline inhibin B and FSH after stimulation with GnRH: a study of serum levels of inhibin A and B, pro alpha-C and activin A in women with ovulatory disturbances before and after stimulation with GnRH

Casper

Seufert²,

Pollow³

2000

European Journal of Endocrinology

View full text Add to dashboard Cite

show abstract

“…Unfortunately, more detailed analyses concluded that early follicular phase inhibin B serum levels are only of limited value in predicting response during ovarian hyperstimulation (18 -21). Dynamic inhibin B testing with FSH stimulation (22,23) or gonadotropin releasing hormone (GnRH) agonist administration (24) appears to correlate better with ovarian response. A good correlation was also observed between inhibin B concentrations during ovarian hyperstimulation and the number of oocytes retrieved (25,26).…”

Section: Introductionmentioning

confidence: 99%

Relationship between inhibin A and B, estradiol and follicle growth dynamics during ovarian stimulation in normo-ovulatory women

Laven¹,

Jong²,

Fauser³

2005

eur j endocrinol

View full text Add to dashboard Cite

Objective: To investigate the relationship between serum concentrations of inhibin A, inhibin B and estradiol (E 2 ) and the number of developing follicles during the administration of exogenous follicle-stimulating hormone (FSH) in various regimens in normo-ovulatory volunteers and to evaluate if inhibins act as suitable markers for the number of developing follicles during ovarian stimulation. Design and methods: Serial hormone determinations and assessment of follicle numbers were carried out during unstimulated cycles and during various interventions with exogenous FSH. Subjects were randomized for FSH administration into the following groups: a single high dose (375 IU) during the early follicular phase (group A), 5 consecutive low doses (75 IU/day) starting in the mid follicular phase (group B) or daily low doses (75 IU/day) during the early to late follicular phase (starting on cycle days 3, 5 or 7; groups C, D and E respectively). Results: Extending the FSH window increases the number of small antral follicles and hence inhibin B serum concentrations. If such an intervention results in multi-follicular growth, mid follicular phase inhibin B (P ¼ 0.001) as well as late follicular phase inhibin B and inhibin A levels are significantly (P , 0.05 and P , 0.01 respectively) increased compared with mono-follicular cycles or the natural cycle. Although mid follicular inhibin B levels correlated well with the number of small antral (P , 0.05) and pre-ovulatory (P , 0.001) follicles in the late follicular phase, mid follicular inhibin A and estradiol serum concentrations only correlated with the number of pre-ovulatory follicles (P , 0.001 and P , 0.01 respectively). Conclusions: The present data extend our understanding of the relationship between follicle dynamics, serum inhibins and FSH during ovarian hyperstimulation. However, although mid follicular inhibin B does correlate with the number of developing follicles, it does not facilitate the identification of women at risk for multiple follicle development.European Journal of Endocrinology 152 395-401

show abstract

“…Inhibin B was suggested as an early sensitive predictor of ovarian reserve (Seifer et al, 1997;. With better understanding of the control of synthesis and secretion of the inhibins and their potential endocrine role in the menstrual cycle, attention has turned to the possibility of this family of peptides to provide a more direct index of ovarian reserve and an improved predictor of ART outcome (Hughes et al, 1990;Groome et al, 1994;Balasch et al, 1996;Lockwood et al, 1996;Seifer et al, 1997;Danforth et al, 1998;Corson et al, 1999;Hall et al, 1999;Peñarrubia et al, 2000;Laven and Fauser, 2004;Shanthi et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Dynamic measurements of serum inhibin B and estradiol: apredictive evaluation of ovarian response to gonadotrophin stimulation in the early stage of IVF treatment

Miao

Huang

2009

J. Zhejiang Univ. Sci. B

View full text Add to dashboard Cite

Abstract:Objective: We dynamically measured serum inhibin B and estradiol in the early stage of hormonal stimulation to predict the ovarian response in in vitro fertilization (IVF) treatment. Methods: A total of 57 patients (<40 years of age) who underwent the first cycle of long protocol IVF or introcytoplasmic sperm injection (ICSI) treatment were included. Serum inhibin B, estradiol, follicle stimulating hormone (FSH) and luteinizing hormone (LH) levels were measured four times: (1) on Day 3 of the menstrual cycle (basal); (2) on the day before the first administration of gonadotrophin (Gn) (Day 0); (3) on Day 1 of Gn therapy; and (4) on Day 5 of Gn therapy. Comparisons of these measurements with ovarian responses and pregnancy outcomes were made and analyzed statistically. Results: (1) On Day 1 and Day 5 of recombinant FSH (rFSH) stimulation, ovarian response, i.e., numbers of follicles, oocytes, fertilized oocytes, and embryos, had a positive correlation (r s =0.46~0.61, P=0.000) with raised inhibin B and estradiol concentrations, but a negative correlation (r s =−0.67~−0.38, P=0.000 or P<0.01) with total rFSH dose and total days of rFSH stimulation. (2) No significant variation (P>0.05) between the pregnant and non-pregnant groups on the basis of mean age or on all hormone concentrations at four times of the IVF cycle was observed. However, all the seven patients aged >35 years did not reach pregnancy. Conclusions: (1) Serum inhibin B and estradiol concentrations obtained shortly after Gn therapy may offer an accurate and early prediction of ovarian response; (2) Low levels of serum inhibin B and estradiol obtained shortly after Gn stimulation indicate the need for a longer period of Gn treatment and a higher daily dosage; (3) No obvious pregnancy difference among patients of age <35 years was found; however, IVF pregnancy outcome is significantly lower in women of age >35 years.

show abstract

Circulating inhibins and activin A during GnRH‐analogue down‐regulation and ovarian hyperstimulation with recombinant FSH for in‐vitro fertilization‐embryo transfer

Cited by 79 publications

References 26 publications

Inverse correlation between baseline inhibin B and FSH after stimulation with GnRH: a study of serum levels of inhibin A and B, pro alpha-C and activin A in women with ovulatory disturbances before and after stimulation with GnRH

Inverse correlation between baseline inhibin B and FSH after stimulation with GnRH: a study of serum levels of inhibin A and B, pro alpha-C and activin A in women with ovulatory disturbances before and after stimulation with GnRH

Relationship between inhibin A and B, estradiol and follicle growth dynamics during ovarian stimulation in normo-ovulatory women

Dynamic measurements of serum inhibin B and estradiol: apredictive evaluation of ovarian response to gonadotrophin stimulation in the early stage of IVF treatment

Contact Info

Product

Resources

About