B cells on the brain: meningeal IgA and a novel gut–brain firewall

Hepworth, Matthew R.; Greenhalgh, Andrew D.; Cook, Peter C.

doi:10.1111/imcb.12412

Cited by 4 publications

(4 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, CIBERSORT analysis showed extensive infiltration by plasma cells in AD/VD. Age-dependent plasma cell accumulation may contribute to cognitive decline and to behavioral or neurodegenerative disorders in humans ( Hepworth et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

REPS1 as a Potential Biomarker in Alzheimer’s Disease and Vascular Dementia

Luo

Chen²,

Huang³

et al. 2022

Front. Aging Neurosci.

View full text Add to dashboard Cite

Vascular dementia (VD) and Alzheimer’s disease (AD) are common types of dementia for which no curative therapies are known. In this study, we identified hub genes associated with AD and VD in order to explore new potential therapeutic targets. Genes differentially expressed in VD and AD in all three datasets (GSE122063, GSE132903, and GSE5281) were identified and used to construct a protein–protein interaction network. We identified 10 modules containing 427 module genes in AD and VD. Module genes showing an area under the diagnostic curve > 0.60 for AD or VD were used to construct a least absolute shrinkage and selection operator model and were entered into a support vector machine-recursive feature elimination algorithm, which identified REPS1 as a hub gene in AD and VD. Furthermore, REPS1 was associated with activation of pyruvate metabolism and inhibition of Ras signaling pathway. Module genes, together with differentially expressed microRNAs from the dataset GSE46579, were used to construct a regulatory network. REPS1 was predicted to bind to the microRNA hsa_miR_5701. Single-sample gene set enrichment analysis was used to explore immune cell infiltration, which suggested a negative correlation between REPS1 expression and infiltration by plasmacytoid dendritic cells in AD and VD. In conclusion, our results suggest core pathways involved in both AD and VD, and they identify REPS1 as a potential biomarker of both diseases. This protein may aid in early diagnosis, monitoring of treatment response, and even efforts to prevent these debilitating disorders.

show abstract

Section: Discussionmentioning

confidence: 99%

REPS1 as a Potential Biomarker in Alzheimer’s Disease and Vascular Dementia

Luo

Chen²,

Huang³

et al. 2022

Front. Aging Neurosci.

View full text Add to dashboard Cite

show abstract

“…Recent evidence points at a role for gut-educated IgA ASCs in modulating antifungal immune responses outside of mucosal tissues. During homeostasis, meninges, the membranes surrounding the brain and spinal cord, contain gut-derived and commensal-specific IgA ASCs 73 . Mice lacking IgA or with a selective loss of meningeal IgA plasma cells exhibit reduced protection against C. albicans and is associated with increased fungal invasion of the brain 74 .…”

Section: Antibody-mediated Immunity Against C Albicansmentioning

confidence: 99%

Immunosurveillance of Candida albicans commensalism by the adaptive immune system

Swidergall

LeibundGut‐Landmann

2022

Mucosal Immunology

View full text Add to dashboard Cite

The fungal microbiota (mycobiota) is an integral part of the microbial community colonizing the body surfaces and is involved in many key aspects of human physiology, while an imbalance of the fungal communities, termed fungal dysbiosis, has been described in pathologies ranging from infections to inflammatory bowel disease. Commensal organisms, such as the fungus Candida albicans, induce antigen-specific immune responses that maintain immune homeostasis. Adaptive immune mechanisms are vital in this process, while deficiencies in adaptive immunity are linked to fungal infections. We start to understand the mechanisms by which a shift in mycobiota composition, in particular in C. albicans abundance, is linked to immunopathological conditions. This review discusses the mechanisms that ensure continuous immunosurveillance of C. albicans during mucosal colonization, how these protective adaptive immune responses can also promote immunopathology, and highlight therapeutic advances against C. albicans-associated disease.

show abstract

“…In the mucosa-associated lymphoid tissue of the gut, specific signals lead to the development of plasma cells that produce IgA [ 126 ]. Researchers have found that IgA plasma cells, which originate in the gut, protect the brain from pathogens [ 127 ]. Compared with normal mice, there was almost no IgA in the meninges of aseptic mice, and the meningeal IgA network was completely restored after the intestinal tract of these mice was reconstructed with microorganisms [ 128 ].…”

Section: Crosstalk Between Brain and Gut Microbiome Have Certain Impa...mentioning

confidence: 99%

Tea Polyphenols as Prospective Natural Attenuators of Brain Aging

Hong

Yu²,

Wang³

et al. 2022

Nutrients

View full text Add to dashboard Cite

No organism can avoid the process of aging, which is often accompanied by chronic disease. The process of biological aging is driven by a series of interrelated mechanisms through different signal pathways, including oxidative stress, inflammatory states, autophagy and others. In addition, the intestinal microbiota play a key role in regulating oxidative stress of microglia, maintaining homeostasis of microglia and alleviating age-related diseases. Tea polyphenols can effectively regulate the composition of the intestinal microbiota. In recent years, the potential anti-aging benefits of tea polyphenols have attracted increasing attention because they can inhibit neuroinflammation and prevent degenerative effects in the brain. The interaction between human neurological function and the gut microbiota suggests that intervention with tea polyphenols is a possible way to alleviate brain-aging. Studies have been undertaken into the possible mechanisms underpinning the preventative effect of tea polyphenols on brain-aging mediated by the intestinal microbiota. Tea polyphenols may be regarded as potential neuroprotective substances which can act with high efficiency and low toxicity.

show abstract

B cells on the brain: meningeal IgA and a novel gut–brain firewall

Cited by 4 publications

References 16 publications

REPS1 as a Potential Biomarker in Alzheimer’s Disease and Vascular Dementia

REPS1 as a Potential Biomarker in Alzheimer’s Disease and Vascular Dementia

Immunosurveillance of Candida albicans commensalism by the adaptive immune system

Tea Polyphenols as Prospective Natural Attenuators of Brain Aging

Contact Info

Product

Resources

About