B-cells in pulmonary arterial hypertension: friend, foe or bystander?
Sébastien Sanges,
Wen Tian,
Sylvain Dubucquoi
et al.
Abstract:There is an unmet need for new therapeutic strategies that target alternative pathways to improve the prognosis of patients with pulmonary arterial hypertension (PAH). As immunity has been involved in the development and progression of vascular lesions in PAH, we review the potential contribution of B cells in its pathogenesis and evaluate the relevance of B cell-targeted therapies. Circulating B cell homeostasis is altered in PAH patients, with total B-cell lymphopenia, abnormal subset distribution (expansion… Show more
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