B cells expressing CD5 in minor labial salivary glands of patients with primary Sjögren's syndrome

Zeher, Margit; Surányi, Péter; Nagy, Gábor; Szegedi, Gyula

doi:10.1002/art.1780330329

Cited by 14 publications

(10 citation statements)

References 5 publications

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“…In contrast to ambient flow cytometry data on CD5 in the literature, this may partly explain the paucity of immunohistochemical reports about CD5 in SS/LSG, in spite of the well‐known fact that SS cases may show high levels of circulating CD5 + lymphocytes [32]. Notably, we readily detected a small number of CD5‐stained cells in the SS/LSG, confirming previous isolated immunohistochemical data [33]. The fact that the present SS/LSG CD5 + infiltrates did not overlap with the CD27 + cells indirectly suggests that neither a correlation with T cells (CD45R0) nor with CD20 + B cells can be excluded.…”

Section: Discussionsupporting

confidence: 84%

Immunohistochemistry of the B‐Cell Component in Lower Lip Salivary Glands of Sjögren's Syndrome and Healthy Subjects

Larsson

Bredberg²,

Henriksson³

et al. 2005

Scand J Immunol

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Serial sections of lower lip salivary gland (LSG) biopsies were examined by immunohistochemistry, using a battery of B- and partly T-related antibodies (CD5, CD20, CD21, CD27, CD38, CD45RO, CD79a, Bcl-2 and Bcl-6) in different groups of subjects: healthy controls and clinically verified smoking or nonsmoking cases of primary Sjögren's syndrome (SS). The purpose was to characterize the B-cell pattern of the lymphocytic foci and of the tiny perivascular infiltrates preceding the development of foci. Hyperplastic tonsil was used as stain control. In normal LSG, widely dispersed CD38+ and CD79a+ as well as some CD5+ cells are a normal constituent, with lack of staining with the other antibodies. In SS/LSG, the lymphocytic foci showed staining with all the antibodies, with variable degrees of overlapping or nonoverlapping. In SS/LSG of nonsmokers, CD20+ B cells make up a prominent part of the fully developed periductal lymphocytic foci, not overlapping with CD45RO. Also, CD20+ B cells did not overlap in the infiltrates with colocalized CD27+/CD38+ cells. CD20+ B cells and CD45RO+ T cells also occur as minute infiltrates perivascularly in areas of no foci in SS/LSG as well as in SS smokers lacking the typical foci. Smokers lack foci, but tiny infiltrates express CD20 as well CD45R0. Our findings suggest that CD20+ B cells and CD45RO+ T cells are early immigrants in the LSG of SS of smokers as well as nonsmokers and that another subgroup of CD27+/CD38+ B cells gradually mix with the first two to form the characteristic foci in SS/LSG. The simultaneous demonstration of CD20+ and CD27+ B cells in SS/LSG may constitute a significant diagnostic tool. Further, the findings suggest that the early immigrating lymphocytes may have been primed at a site remote from the glands before arriving via the blood to the gland tissue.

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Section: Discussionsupporting

confidence: 84%

Immunohistochemistry of the B‐Cell Component in Lower Lip Salivary Glands of Sjögren's Syndrome and Healthy Subjects

Larsson

Bredberg²,

Henriksson³

et al. 2005

Scand J Immunol

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“…2 did not show any signs of overt autoimmune disease. In patients with Sjogren syndrome, reactive lymphoid lesions are present in the salivary glands, and an infiltration by CD5+ B cells is observed in 5–16% of cases 12. Reactive lymphoid hyperplasia may incubate one or more clones of emerging B cells 13.…”

Section: Discussionmentioning

confidence: 99%

Correlation of autoantibodies and CD5+ B cells in ocular adnexal marginal zone B cell lymphomas

et al. 2009

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“…In general, the levels of CD5 + B cells are independent of disease activity [50,56,61] in auto-immune conditions. This is consistent with data obtained on repeated blood samples from the same normal volunteers, in whom the percentages of CD5 + B cells were constant over time [62].…”

Section: Other Non Organ-specific Auto-immune Diseusesmentioning

confidence: 99%

Human CD5‐positive B Cells in lymphoid malignancy and connective tissue diseases

Youinou

Mackenzie

Lamour

et al. 1993

Eur J Clin Investigation

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Abstract. The current literature on human CD5-positive B cells (CD5 + B cells) has been analysed, with a special emphasis on non organ-specific auto-immune diseases. Malignant cells of most of the chronic lymphoid leukaemias of the B cell lineage express the CD5 molecule. Antibodies of the IgM class produced by leukaemic B cells are multispecific auto-antibodies. The CD5+B cell subset may be expanded in non organ-specific autoimmune diseases, such as rheumatoid arthritis, primary Sjogren's syndrome, systemic lupus erythematosus. This holds true for various conditions, including organ-specific auto-immune diseases. Since auto-immune features are common in lymphoproliferative disorders, and the latter be a complication in non organ-specific auto-immune diseases, CD5 + B cells may represent an intermediatary between these auto-immune diseases and B cell lymphoproliferations. Studies on the regulation of CDS+B cell production and function are likely to shed light on the aetiology of, and pathogenetic mechanisms operating in the different disease states.

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B cells expressing CD5 in minor labial salivary glands of patients with primary Sjögren's syndrome

Abstract: LETTERS 453fects on homologous versus heterologous collagen-induced arthritis in rats.

Cited by 14 publications

References 5 publications

Immunohistochemistry of the B‐Cell Component in Lower Lip Salivary Glands of Sjögren's Syndrome and Healthy Subjects

Immunohistochemistry of the B‐Cell Component in Lower Lip Salivary Glands of Sjögren's Syndrome and Healthy Subjects

Correlation of autoantibodies and CD5+ B cells in ocular adnexal marginal zone B cell lymphomas

Human CD5‐positive B Cells in lymphoid malignancy and connective tissue diseases

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