B-cell–T-cell activation and interaction in common variable immunodeficiency

Rezaei, Nima; Wing, James B.; Aghamohammadi, Asghar; Carlring, Jennifer; Lees, Andrew; Asgarian-Omran, Hossein; Pourpak, Zahra; Sarrafnejad, Abdolfattah; Kardar, Gholam Ali; Shahrestani, Tahereh; Masoumi, Farimah; Zare, Ahad; Saghafi, Shiva; Sarrafzadeh, Shokouh Azam; Foster, Rachel; Heath, Andrew W.; Read, Robert C.

doi:10.1016/j.humimm.2010.01.019

Cited by 25 publications

(17 citation statements)

References 31 publications

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“…Our study also highlights the importance of considering T-cell activation [12,13] in PHID (clusters 3 and 4 with increased T-cell activation with the highest percentage of complications, comprising mainly CVID patients and the three patients with Good’s syndrome identified in our cohort as PHID types). Moreover, the occurrence of two complications considered in addition to those defined by H Chapel et al [6] (ie: splenomegaly and granulomatous disease) were found with the highest frequency in the clusters 3 and 4 with increased T-cell activation, suggesting that the HLA-DR + activation marker could help to discriminate them.…”

Section: Discussionsupporting

confidence: 55%

“…Giovanetti et al [11] performed an in-depth analysis of the T-cell compartment in CVID patients and demonstrated multiple T-cell abnormalities. T-cell activation is an important process underlined [12,13] that need to be explored, together with T-cell regulation [14,15]. Indeed, gammadelta T cells [16] and innate cell abnormalities reported in Natural Killer cells (NK) [17] or myeloid dendritic (mDC) and plasmacytoid dendritic cells (pDC) [18] may further contribute to the heterogeneous presentation of CVID.…”

Section: Introductionmentioning

confidence: 99%

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T-cell activation discriminates subclasses of symptomatic primary humoral immunodeficiency diseases in adults

et al. 2014

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BackgroundSymptomatic Primary Humoral Immunodeficiency Diseases (PHID) constitute a highly heterogeneous group of diseases characterized by a shared hypogammaglobulinemia, resulting in increased risk of recurrent or severe infections. Associations have been described with a variety of immunological abnormalities involving B and T-cell differentiation, T-cell activation and innate immunity. However, PHID discrimination remains based on B-lymphocyte abnormalities and other components of the immune system have not been sufficiently taken into account. We carried out unsupervised and supervised methods for classification in a cohort of 81 symptomatic PHID patients to evaluate the relative importance of 23 immunological parameters and to select relevant markers that may be useful for diagnosis and prognosis.ResultsWe identified five groups of patients, among which the percentage of PHID complications varied substantially. Combining the set of markers involved in PHID supported the existence of two distinct mechanisms associated with complications. Switched memory B-cell attrition and CD8+ HLA-DR + activated T-cell increase were the prominent abnormalities observed in PHID complications. Furthermore, in a subgroup of 57 patients with common variable immunodeficiency, the classification that added CD8+ HLA-DR + to the consensual EUROclass classification was better than the EUROclass model in predicting complications.ConclusionThese results highlight the importance of T-cell activation that may improve discrimination of PHID patients in specific subgroups and help to identify patients with different clinical outcomes.

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Section: Discussionsupporting

confidence: 55%

Section: Introductionmentioning

confidence: 99%

T-cell activation discriminates subclasses of symptomatic primary humoral immunodeficiency diseases in adults

et al. 2014

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“…1b). As expected [11][12][13]17 a-o-dex induced B-cell activation, leading to significant increases in B-cell CD86 and CD25 expression (see Supporting information, Fig. S1).…”

Section: Igd Stimulation Of B Cells Inhibits T Cell Activation and Prsupporting

confidence: 80%

Contact‐dependent suppression of CD4 T‐cell activation and proliferation by B cells activated through IgD cross‐linking

et al. 2015

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SummaryAlthough the co-stimulatory interaction between B and T cells is well defined, recent evidence suggests that B cells also have a regulatory role. Here, we show that B cells activated using anti-IgD conjugated to dextran (a-d-dex) directly inhibit T-cell receptor-induced CD4 T-cell activation, proliferation and cytokine production. This effect was observed in CD4 T cells activated both with and without CD28 co-stimulation. T-cell viability was unaffected, and the T-cell suppressive effect was mediated by contact with IgD-activated purified B cells and not by interleukin-10 or other soluble factors. This is the first evidence of IgD-activated B cells mediating inhibition of activation and proliferation of CD4 T cells in humans.

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“…However, an alteration in the frequency and function of T cells has also been demonstrated in patients with CVID [12][13][14]. The influence of these defects on the interaction between T and B cells could explain not only defective antibody production, but also the development of other complications, including recurrent bacterial and viral infections, gastrointestinal disease, lymphoma, autoimmunity, inflammation, and early-onset bronchiectasis in CVID patients [15][16][17]. In this review, we describe phenotypic and functional T-cell defects in patients with CVID and review the literature on the effects of intravenous immunoglobulin (IVIG) infusion on T-cell components in CVID.…”

Section: Common Variable Immunodeficiency (Cvid) Is the Most Common Cmentioning

confidence: 99%

T-Cell Abnormalities in Common Variable Immunodeficiency

Azizi

Rezaei

Kiaee

et al. 2016

J Investig Allergol Clin Immunol

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Common variable immunodeficiency (CVID) is the most common clinical primary immunodeficiency. It is characterized by a defect in B-cell differentiation to plasma and memory B cells. Moreover, numerous T-cell abnormalities have been reported and include decreased T-cell count and proliferative response, increased T-cell activation and apoptosis, and abnormalities in cytokine production. The aims of this review are to describe phenotypic and functional defects in T cells in CVID patients and to review the literature with respect to the effects of immunoglobulin replacement on the T-cell component in CVID patients. Key words: Common variable immunodeficiency. T cell. Helper T cells. Regulatory T cells. ResumenLa inmunodeficiencia común variable (CVID) es la inmunodeficiencia primaria más frecuente. Se caracteriza por un defecto en la diferenciación de linfocitos B hacia células plasmáticas y linfocitos B memoria. Se han descrito numerosas alteraciones en los linfocitos T de estos pacientes, tales como disminución en el número de linfocitos T y en sus respuestas proliferativas, aumento en la activación de células T y en la apoptosis, así como alteraciones en la producción de citokinas. El objetivo de esta revisión es describir las alteraciones funcionales y fenotípicas de los linfocitos T en los pacientes con CVID y revisar la bibliografía en relación a los efectos que la administración de inmunoglobulinas produce en los linfocitos T de los pacientes con CVID. Palabras clave: Inmunodeficiencia común variable. Células T. Células T helper. Células T reguladoras.

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B-cell–T-cell activation and interaction in common variable immunodeficiency

Cited by 25 publications

References 31 publications

T-cell activation discriminates subclasses of symptomatic primary humoral immunodeficiency diseases in adults

T-cell activation discriminates subclasses of symptomatic primary humoral immunodeficiency diseases in adults

Contact‐dependent suppression of CD4 T‐cell activation and proliferation by B cells activated through IgD cross‐linking

T-Cell Abnormalities in Common Variable Immunodeficiency

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