<b>Cell‐Penetrating Peptide‐Conjugated Polymer Micelle for pDNA/siRNA Delivery</b>

Kanazawa, Takanori

doi:10.1002/9783527835997.ch16

Cited by 1 publication

(1 citation statement)

References 84 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Typically, ligands are conjugated to the outer ends of the hydrophilic segment to modify polymeric micelles for active targeting [ 65 ]. Targeting ligands used to create polymeric micellar systems are typically categorized as (a) small molecular weight molecules (e.g., folic acid [ 66 ], sialic acid [ 67 ], biotin [ 68 ]); (b) antibodies and their fragments [ 69 ]; (c) peptides and proteins such as trans-activator of transcription (TAT) peptide [ 70 ] and arginine–glycine–aspartic acid (RGD) peptide [ 71 ]; and (d) aptamers [ 72 ]. Due to their high binding affinity and specificity for tumor cells, antibodies and peptides are proven to be superior ligands.…”

Section: General Issues and Status Quo Of Polymeric Micellesmentioning

confidence: 99%

Polymeric Micellar Systems—A Special Emphasis on “Smart” Drug Delivery

Neguț

Biţă

2023

Pharmaceutics

View full text Add to dashboard Cite

Concurrent developments in anticancer nanotechnological treatments have been observed as the burden of cancer increases every year. The 21st century has seen a transformation in the study of medicine thanks to the advancement in the field of material science and nanomedicine. Improved drug delivery systems with proven efficacy and fewer side effects have been made possible. Nanoformulations with varied functions are being created using lipids, polymers, and inorganic and peptide-based nanomedicines. Therefore, thorough knowledge of these intelligent nanomedicines is crucial for developing very promising drug delivery systems. Polymeric micelles are often simple to make and have high solubilization characteristics; as a result, they seem to be a promising alternative to other nanosystems. Even though recent studies have provided an overview of polymeric micelles, here we included a discussion on the “intelligent” drug delivery from these systems. We also summarized the state-of-the-art and the most recent developments of polymeric micellar systems with respect to cancer treatments. Additionally, we gave significant attention to the clinical translation potential of polymeric micellar systems in the treatment of various cancers.

show abstract