B cell lymphomas express CX3CR1 a non-B cell lineage adhesion molecule

Andréasson, Ulrika; Ek, Sara; Merz, Hartmut; Rosenquist, Richard; Andersen, Niels Smedegaard; Jerkeman, Mats; Dictor, Michael; Borrebaeck, Carl

doi:10.1016/j.canlet.2007.10.031

Cited by 23 publications

(36 citation statements)

References 17 publications

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“…To date, there is no report on CXCR1/CXCR2 inhibition in B-CLL. Nevertheless, CXCL8 serum levels were found to correlate Andreasson et al [71] with important clinical features, such as ß2-microglobulin (ß2-MG) and the stages of the Rai classification (Table 2) [41,42]. In contrast, another study performed by Molica et al failed to correlate any of the clinico-biological features (like ß2-MG, BM involvement or clinical stage) with CXCL8 serum levels [46], although elevated CXCL8 serum levels were associated with significantly shorter survival, progress to a more advanced clinical stage of disease and increased activity of the leukemic clone [46][47][48].…”

Section: Cxcl8 (Il-8) and Its Receptors Cxcr1 And Cxcr2mentioning

confidence: 97%

“…Since ZAP70 is known to be closely correlated to unmutated VH status (which is an established prognostic marker), CX3CR1 might also be regarded as a novel prognostic tool [70]. Furthermore, Andreasson et al [71] demonstrated that CX3CR1 is expressed on several lymphoma subtypes (including B-CLL cells) and therefore suggests a possible role for this receptor in lymphoma dissemination. CX3CR1 antagonists are currently being developed and may contribute to increasing insight into this chemokine/receptor complex in B-CLL pathophysiology [72,73].…”

Section: Cx3cl1 and Its Receptor Cx3cr1mentioning

confidence: 99%

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The role of chemokines in B cell chronic lymphocytic leukaemia: pathophysiological aspects and clinical impact

2009

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International audienceChemokines are centrally involved in leukocyte migration, homing and haematopoiesis. Besides these physiological aspects, their role in pathological processes especially with respect to solid tumour and haematological neoplasias is well established. In this context, the focus was set here on disclosing their contribution in B cell chronic lymphocytic leukaemia (B-CLL), which is regarded as the most characteristic low-grade lymphoma. Up to now, it has been demonstrated that several chemokines are involved in migration of B-CLL cells to lymph nodes, secondary lymphoid organs and bone marrow. Moreover, some chemokines are known to have an anti-apoptotic effect and thus contribute to the survival of B-CLL cells. By interfering with both of these aspects, new therapeutic targets for this yet incurable disease may be developed. Furthermore, a correlation can be drawn between the concentration of some chemokines in patients' serum, the expression of their respective receptors on B-CLL cells and well-established predictive clinical parameters. Consequently, further systematic investigation of the chemokine network may lead to the identification of new diagnostic and prognostic markers. This review focuses on the impact of chemokines and their receptors on B-CLL pathophysiology and points out potential implications for both treatment and diagnosis

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Section: Cxcl8 (Il-8) and Its Receptors Cxcr1 And Cxcr2mentioning

confidence: 97%

Section: Cx3cl1 and Its Receptor Cx3cr1mentioning

confidence: 99%

The role of chemokines in B cell chronic lymphocytic leukaemia: pathophysiological aspects and clinical impact

2009

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“…The fraction of tumor cells in the samples before sorting varied (Results section) but all samples were generally purified to >97% as assessed by FACS analysis. The isolated cells were then lysed in Trizol (Invitrogen Corporation, CA), as previously described [20]. The patient material details are shown in Table I.…”

Section: Collection and Isolation Of Tumor Cellsmentioning

confidence: 99%

Identification of uniquely expressed transcription factors in highly purified B‐cell lymphoma samples

et al. 2010

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Transcription factors (TFs) are critical for B-cell differentiation, affecting gene expression both by repression and transcriptional activation. Still, this information is not used for classification of B-cell lymphomas (BCLs). Traditionally, BCLs are diagnosed based on a phenotypic resemblance to normal B-cells; assessed by immunohistochemistry or flow cytometry, by using a handful of phenotypic markers. In the last decade, diagnostic and prognostic evaluation has been facilitated by global gene expression profiling (GEP), providing a new powerful means for the classification, prediction of survival, and response to treatment of lymphomas. However, most GEP studies have typically been performed on whole tissue samples, containing varying degrees of tumor cell content, which results in uncertainties in data analysis. In this study, global GEP analyses were performed on highly purified, flow-cytometry sorted tumor-cells from eight subgroups of BCLs. This enabled identification of TFs that can be uniquely associated to the tumor cells of chronic lymphocytic leukemia (CLL), diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), hairy cell leukemia (HCL), and mantle cell lymphoma (MCL). The identified transcription factors influence both the global and specific gene expression of the BCLs and have possible implications for diagnosis and treatment. Am. J. Hematol. 85:418-425, 2010. V

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“…Fractalkine possesses pro and anti-tumor properties and is a major mediator of central and peripheral pain (4,5). The role of fractalkine and of its receptor in haematological diseases is less studied (6,7,8,9).…”

Section: Introductionmentioning

confidence: 99%

CX3CR1 expression and megakaryocytic series assessment on bone marrow biopsies in acquired aplastic anemia. Correlations with hematological parameters.

Gavrilut

Bondor

Fetică

et al. 2015

Revista Romana De Medicina De Laborator

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B cell lymphomas express CX3CR1 a non-B cell lineage adhesion molecule

Cited by 23 publications

References 17 publications

The role of chemokines in B cell chronic lymphocytic leukaemia: pathophysiological aspects and clinical impact

The role of chemokines in B cell chronic lymphocytic leukaemia: pathophysiological aspects and clinical impact

Identification of uniquely expressed transcription factors in highly purified B‐cell lymphoma samples

CX3CR1 expression and megakaryocytic series assessment on bone marrow biopsies in acquired aplastic anemia. Correlations with hematological parameters.

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