B-Cell Lymphoma/Burkitt Lymphoma

Linfoma de Burkitt nasofaríngeo

“…Es infrecuente su localización en cabeza y cuello, pero de presentarse en dichas zonas, se presentan como adenopatías cervicales, seguido de localización en maxilar, nasofaringe, mandíbula y amígdalas. 6,7 Para establecer el diagnóstico se requiere la combinación de parámetros genéticos, histológicos y por inmunofenotipo. Por histología se observan células homogéneas con núcleos ovales con nucléolos basófilos y www.medigraphic.org.mx citoplasma abundante y claro.…”

“…El linfoma de Burkitt fue descubierto a principios del siglo XX, siendo Denis Burkitt en 1958 quien proporcionó la descripción detallada de esta patología; además, fue el primer tumor asociado a etiología viral y en demostrarse una translocación cromosómica activadora del oncogén. [5][6][7] Se origina por una proliferación clonal de las células tipo B del centro germinal ocasionado principalmente por la translocación t (8,14), la cual está presente en la mayoría de este tipo de linfomas. [7][8][9] Fuera de África existe poca literatura acerca de la presentación de linfomas de Burkitt en la nasofaringe.…”

Epidemiology and management of lymphoma in low‐income countries

“…The study of Burkitt lymphoma has resulted in important advances in the understanding of the pathogenesis and treatment of lymphoid neoplasms in general 7, 8. Its climate‐related distribution pattern in equatorial Africa suggested the possibility of the involvement of an arthropod‐vectored virus in its aetiology, which led to the discovery of Epstein Barr virus 7, 9, the first description of a virus involved in the pathogenesis of a human tumour.…”

“…The study of Burkitt lymphoma has resulted in important advances in the understanding of the pathogenesis and treatment of lymphoid neoplasms in general 7, 8. Its climate‐related distribution pattern in equatorial Africa suggested the possibility of the involvement of an arthropod‐vectored virus in its aetiology, which led to the discovery of Epstein Barr virus 7, 9, the first description of a virus involved in the pathogenesis of a human tumour. However, Burkitt lymphoma also provided an important model for a major pathogenetic pathway in lymphoid neoplasms whereby chromosomal translocations result in the juxtaposition (and consequent deregulation) of protooncogenes and/or genes involved in apoptosis ( MYC in the case of Burkitt lymphoma) to regulatory sequences within the immunoglobulin or T‐cell receptor loci 8, 10.…”

“…Unfortunately, resource limitations result in inordinate delays in diagnosis, presentation with advanced, generally incurable disease, and support for the assumption that cancer is, in any event, invariably fatal. This is not, however, the case with Burkitt lymphoma, which is potentially curable even when widespread at diagnosis (although survival rates correlate with clinical stage) 7, 8 and which, therefore, can be used to demonstrate to policy makers and the public, that cancer can be cured. In this context, in spite of some controversies on its priority 14, 15, research on Burkitt's lymphoma in African children continues to be extremely important to properly address local heath needs 14, 16, 17.…”