B‐cell lymphoblastic lymphoma with cutaneous involvement and a <scp><i>KMT2A</i></scp> gene rearrangement

Kemps, Paul Geraeds; Cleven, Arjen H.G.; Wezel, Tom van; Eijk, Ronald van; Bot, Fredrik J.; Veelken, Hendrik; Balen, Peter van; Kerkhoffs, Jean-Louis

doi:10.1002/ajh.25801

Cited by 4 publications

(2 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similar findings were also reported in adult BCP-L, and infantile BCP-ALL with KMT2A rearrangements [6,13]. To our knowledge, except for isolated case reports [14], our study is the first to report that KMT2A breakpositive BCP-L are significantly associated with skin involvement compared to KMT2A-negative cases, outside of infantile BCP-ALL cases.…”

Section: To the Editorsupporting

confidence: 89%

Frequency and prognostic implications of KMT2A rearrangements in children with precursor B-cell lymphoma

et al. 2022

View full text Add to dashboard Cite

Section: To the Editorsupporting

confidence: 89%

Frequency and prognostic implications of KMT2A rearrangements in children with precursor B-cell lymphoma

et al. 2022

View full text Add to dashboard Cite

“…Epigenetic modulators, such as histone-lysine N-methyltransferases 2A and 2B (KMT2A and KMT2B) (Fig. 3 A) were present in all donor EVs [ 24 ]. Also present were chromodomain-helicase-DNA-binding proteins 1 and 3 (CHD1 and CHD3) (Fig.…”

Section: Resultsmentioning

confidence: 99%

Proteomic analysis of bone marrow-derived mesenchymal stem cell extracellular vesicles from healthy donors: implications for proliferation, angiogenesis, Wnt signaling, and the basement membrane

et al. 2021

View full text Add to dashboard Cite

Background Bone marrow-derived mesenchymal stem cells (BM-MSCs) have shown therapeutic potential in various in vitro and in vivo studies in cutaneous wound healing. Furthermore, there are ubiquitous studies highlighting the pro-regenerative effects of BM-MSC extracellular vesicles (BM-MSC EVs). The similarities and differences in BM-MSC EV cargo among potential healthy donors are not well understood. Variation in EV protein cargo is important to understand, as it may be useful in identifying potential therapeutic applications in clinical trials. We hypothesized that the donors would share both important similarities and differences in cargo relating to cell proliferation, angiogenesis, Wnt signaling, and basement membrane formation—processes shown to be critical for effective cutaneous wound healing. Methods We harvested BM-MSC EVs from four healthy human donors who underwent strict screening for whole bone marrow donation and further Good Manufacturing Practices-grade cell culture expansion for candidate usage in clinical trials. BM-MSC EV protein cargo was determined via mass spectrometry and Proteome Discoverer software. Corresponding proteomic networks were analyzed via the UniProt Consortium and STRING consortium databases. Results More than 3000 proteins were identified in each of the donors, sharing > 600 proteins among all donors. Despite inter-donor variation in protein identities, there were striking similarities in numbers of proteins per biological functional category. In terms of biologic function, the proteins were most associated with transport of ions and proteins, transcription, and the cell cycle, relating to cell proliferation. The donors shared essential cargo relating to angiogenesis, Wnt signaling, and basement membrane formation—essential processes in modulating cutaneous wound repair. Conclusions Healthy donors of BM-MSC EVs contain important similarities and differences among protein cargo that may play important roles in their pro-regenerative functions. Further studies are needed to correlate proteomic signatures to functional outcomes in cutaneous repair.

show abstract

Identification of KMT2A-ARHGEF12 fusion in a child with a high-grade B-cell lymphoma

et al. 2021

View full text Add to dashboard Cite

B‐cell lymphoblastic lymphoma with cutaneous involvement and a KMT2A gene rearrangement

Cited by 4 publications

References 6 publications

Frequency and prognostic implications of KMT2A rearrangements in children with precursor B-cell lymphoma

Frequency and prognostic implications of KMT2A rearrangements in children with precursor B-cell lymphoma

Proteomic analysis of bone marrow-derived mesenchymal stem cell extracellular vesicles from healthy donors: implications for proliferation, angiogenesis, Wnt signaling, and the basement membrane

Identification of KMT2A-ARHGEF12 fusion in a child with a high-grade B-cell lymphoma

Contact Info

Product

Resources

About