B cell-activating factor is associated with the histological severity of nonalcoholic fatty liver disease

Miyake, Teruki; Abe, Masanori; Terada, Yoshio; Hirooka, Masashi; Furukawa, Shinya; Kumagi, Teru; Hamada, Maho; Kawasaki, Keitarou; Tada, Fujimasa; Ueda, T.; Hiasa, Yoichi; Matsuura, Bunzo; Onji, Morikazu

doi:10.1007/s12072-012-9345-8

Cited by 48 publications

(37 citation statements)

References 44 publications

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“…14 The present data seem to be inconsistent with those of our previous study. However, Bigorgne et al 32 showed that steatosis increases lymphocyte recruitment to the liver.…”

Section: Discussioncontrasting

confidence: 99%

“…We previously showed that BAFF impairs insulin sensitivity and is associated with NAFLD severity, 13,14 indicating that this molecule is an important factor in lipid and glucose metabolism. In this study, as expected, HFD-fed BAFF-R À / À mice showed lower body weight gain.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, we found that NASH patients have higher serum BAFF levels than simple steatosis patients. 14 Collectively, these data indicate that BAFF is involved in the induction of the 'second hit' that is thought to be required for NASH development mediated by BAFF-R. However, the direct roles played by BAFF and BAFF-R in hepatic fat accumulation have not been ascertained.…”

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confidence: 95%

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Blockade of B-cell-activating factor signaling enhances hepatic steatosis induced by a high-fat diet and improves insulin sensitivity

Kawasaki

Abe

Tada

et al. 2013

Laboratory Investigation

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À mice fed a high-fat diet (HFD). Furthermore, the effect of BAFF on lipid metabolism in hepatocytes was analyzed in vitro. BAFF-R À / À mice showed improvements in HFD-induced obesity and insulin resistance. In addition, the number of B cells, levels of serum IgG, and inflammation of visceral fat were reduced in these mice. However, the expression of steatogenic genes and fatty acid deposition in the liver was higher in these mice than in control mice. BAFF was also found to downregulate the expression of steatogenesis genes and enhance steatosis in hepatocytes through BAFF-R. Collectively, these data indicated that, in addition to its known functions in inflammation and glucose metabolism, BAFF has a protective role in hepatic steatosis by regulating lipid metabolism in the liver.

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“…14 The present data seem to be inconsistent with those of our previous study. However, Bigorgne et al 32 showed that steatosis increases lymphocyte recruitment to the liver.…”

Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 95%

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Blockade of B-cell-activating factor signaling enhances hepatic steatosis induced by a high-fat diet and improves insulin sensitivity

Kawasaki

Abe

Tada

et al. 2013

Laboratory Investigation

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“…They also found that treatment with recombinant BAFF protein impaired insulin-mediated glucose uptake in 3T3-L1 adipocytes. BAFF plasma levels were significantly correlated with body fat and dietary composition in obese CentralEuropean Caucasian individuals [5], and the levels were also observed to be significantly higher in Japanese patients with nonalcoholic fatty liver disease [6].…”

Section: Introductionmentioning

confidence: 89%

B-cell-activating factor deficiency attenuates high-fat diet-induced glucose intolerance by potentiating adipose tissue function

Kim

Hyun

2015

Biochemical and Biophysical Research Communications

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“…Meanwhile, approximately 20-30% of patients with NAFLD, which is characterized by obesity, insulin resistance and other excessive nutritional intake, had ANA in their sera, suggesting that the autoimmune response might be involved in the process of insulin resistance [62][63][64][65]. The elevation of serum B-lymphocyte activating factor (BAFF) levels in patients with nonalcoholic steatohepatitis (NASH) may be attributed to insulin resistance [66].…”

Section: Autoantibodies In Sera Of Patients With Liver Disease Associmentioning

confidence: 99%

Relationship between Autoimmunity and Cancer or Metabolic Abnormality in Liver Diseases

Himoto¹,

Nishioka²,

Masaki³

2014

TOAUTOJ

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Recent advances in the serological analysis of recombinant cDNA expression libraries and proteomic analysis have enabled the identification of numerous kinds of novel autoantigens, especially tumor-associated antigens (TAAs). The emergence of antibodies to TAAs might imply that an autoimmune response was involved in the malignant transformation. These autoantibodies to TAAs often have predictive value as well as diagnostic relevance. Similarly, the relationship between autoimmunity and metabolic abnormalities, including insulin resistance and hepatic steatosis, has been also documented. Metabolic abnormalities are frequently associated with autoimmune diseases. In contrast, autoimmune reactions were occasionally involved in the process of metabolic dysregulation. This review primarily focuses on the current trends for the relationship between autoimmunity and cancer or metabolic abnormalities in liver disease and the current interpretations of autoantibodies in those diseases.

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B cell-activating factor is associated with the histological severity of nonalcoholic fatty liver disease

Abstract: Nonalcoholic steatohepatitis patients had higher levels of serum BAFF than patients with SS, and higher levels were associated with the presence of hepatocyte ballooning and advanced fibrosis. The serum BAFF level may be a useful tool for distinguishing NASH from SS.

Cited by 48 publications

References 44 publications

Blockade of B-cell-activating factor signaling enhances hepatic steatosis induced by a high-fat diet and improves insulin sensitivity

Blockade of B-cell-activating factor signaling enhances hepatic steatosis induced by a high-fat diet and improves insulin sensitivity

B-cell-activating factor deficiency attenuates high-fat diet-induced glucose intolerance by potentiating adipose tissue function

Relationship between Autoimmunity and Cancer or Metabolic Abnormality in Liver Diseases

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