B Cell-Activating Factor Is a Novel Diagnosis Parameter for Asthma

Kang, Jong Soon; Yoon, Yeo-Dae; Ahn, Joonghyun; Kim, Seokchan; Kim, Kwan-Hyoung; Kim, Hwan‐Mook; Moon, Eun‐Yi

doi:10.1159/000094897

Cited by 49 publications

(50 citation statements)

References 55 publications

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“…When treated with normal mouse IgG control, no changes were detected ( Figure 3D). As shown in Figure 3E, BAFF protein expression in spleen cells was also reduced by the treatment with various concentrations of TACI:Fc and dexamethason (Dex), as a effective anti-asthmatic control agent (Bonacci et al, 2006;Kang et al, 2006). It strengthens above suggestion that BAFF could be a useful target to develop anti-asthmatic therapeutics.…”

Section: Taci:fc Reduced Baff Expressionsupporting

confidence: 71%

“…Previously, we reported that BAFF expression was increased by LPS-stimulated ROS production through nuclear translocation of NF-B . BAFF could be a novel parameter to moritor the severity of asthma symptom (Kang et al, 2006). In this study, we investigated whether scavenging BAFF with TACI:Fc in-hibits OVA-induced asthmatic symptom.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, BAFF induces class-switch DNA recombination to produce IgG, IgA and IgE (Litinskiy et al, 2002), which is in relation to Th2-mediated immune reaction-mediated allergic disorder such as asthma (Rackeman, 1947;Ostergaard, 1985;Corrigan, 2004). Our previous reports show that BAFF protein level was higher in asthma patient, suggesting that BAFF could be a novel diagnostic parameter and a novel therapeutic target to treat asthma (Kang et al, 2006). As the spleen cells were stimulated with Toll-like receptor 4 agonist, LPS, BAFF expression was dependent on reactive oxygen species (ROS) production .…”

Section: Introductionmentioning

confidence: 96%

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TACI:Fc scavenging B cell activating factor (BAFF) alleviates ovalbumin-induced bronchial asthma in mice

Moon

Ryu²

2007

Exp Mol Med

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Asthma was induced by the sensitization and challenge with ovalbumin (OVA) in mice. B-cell activating factor (BAFF) plays a role in mature B cell generation and maintenance. Here, we investigated whether, BAFF expression was changed in OVA-induced mice and whether the control of BAFF expression level alleviates the symptom of bronchial asthma. BAFF expression was detected in alveolar-associated cells surrounding bronchi of OVA-induced mouse lung tissues. BAFF protein was also increased in OVA-induced mouse serum. The increased BAFF transcripts was detected in OVA-induced mouse splenocytes. OVA-induced asthma was associated with the increased number of eosinophils in bronchoalveolar lavage fluid (BALF). When TACI:Fc scavenging soluble BAFF was injected to OVA-induced mice, a significant inhibition was detected in the thickness of airway smooth muscle and glycol-containing cellular elements in airway that were visualized by hematoxylin/eosin Y and periodic acid-Schiff staining, respectively. In addition, when mice were treated with TACI:Fc protein, BAFF protein level was decreased in alveolar-associated cells surrounding bronchi of OVA-induced mouse lung tissues compared to control mice. When compared to OVA-induced control, TACI:Fc treatment reduced the percentage of non-lymphoid cells and no changes were detected in lymphoid cell population. Hypodiploid cell formation in BALF was decreased by OVA-challenge but it was recovered by TACI:Fc treatment. Collectively, data suggest that asthmatic symptom could be alleviated by scavenging BAFF and then BAFF could be a novel target for the develpoment of anti-asthmatic agents.

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Section: Taci:fc Reduced Baff Expressionsupporting

confidence: 71%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

See 1 more Smart Citation

TACI:Fc scavenging B cell activating factor (BAFF) alleviates ovalbumin-induced bronchial asthma in mice

Moon

Ryu²

2007

Exp Mol Med

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“…Regulation of the extrafollicular foci response is also mediated by cytokines, and especially BAFF, which we find to be elevated in IL-18-injected mice, has been suggested to be an important factor (44). Moreover, BAFF Tg mice develop autoimmune manifestations (21) and increased serum levels of BAFF have been reported in a number of autoimmune and allergic conditions (45,46). In relation to autoimmune disease, mounting evidence now shows that expansion of autoreactive B cells can take place at extrafollicular sites (44,47).…”

Section: Discussionsupporting

confidence: 53%

The inflammatory cytokine IL-18 induces self-reactive innate antibody responses regulated by natural killer T cells

Enoksson

Grasset

Hägglöf

et al. 2011

Proc. Natl. Acad. Sci. U.S.A.

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Inflammatory responses initiate rapid production of IL-1 family cytokines, including IL-18. This cytokine is produced at high levels in inflammatory diseases, including allergy and autoimmunity, and is known to induce IgE production in mice. Here we provide evidence that IL-18 is directly coupled to induction of self-reactive IgM and IgG antibody responses and recruitment of innate B2 B cells residing in the marginal zone of the spleen. Moreover, the data suggest that the B-cell activation occurs predominantly in splenic extrafollicular plasma cell foci and is regulated by natural killer T (NKT) cells that prevent formation of mature germinal centers. We also find evidence that NKT cells control this type of B-cell activation via cytotoxicity mediated by both the perforin and CD95/CD178 pathways. Thus, NKT cells regulate innate antibody responses initiated by an inflammatory stimulus, suggesting a general mechanism that regulates B-cell behavior in inflammation and autoreactivity.

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“…In patients with asthma, serum BAFF level was found to be high in both IgE-mediated and non-IgE-mediated asthma suggesting that BAFF might reflect an inflammation in airways without any correlation to IgE antibodies production [12]. This concept was verified by, Kato et al, who demonstrated that following allergen exposure BAFF was upregulated locally in the airways of allergic subjects (asthma and allergic rhinitis) [13].…”

Section: Discussionmentioning

confidence: 94%