B-cell activating factor genetic variants in lymphomagenesis associated with primary Sjogren's syndrome

Nezos, Adrianos; Papageorgiou, Alexia; Fragoulis, G.; Ioakeimidis, Dimitrios; Koutsilieris, Michael; Tzioufas, Athanasios G.; Moutsopoulos, Haralampos Μ.; Voulgarelis, Michael; Mavragani, Clio P.

doi:10.1016/j.jaut.2013.04.005

Cited by 102 publications

(91 citation statements)

References 39 publications

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“…It has been also demonstrated that BAFF level correlated significantly with some important B-cell chronic lymphocytic leukemia (B-CLL) clinical prognostic parameters (2). The genetic variants of BAFF have been shown to be associated with the risk of primary Sjogren's syndrome (pSS) (3,4). Moreover, single-nucleotide polymorphisms (SNPs) in BAFF and BAFF receptor (BAFF-R or BAFF receptor 3 (BR3)] genes have been reported to be associated with NHLs including B-CLL (5)(6)(7).…”

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confidence: 99%

Polymorphisms in genes of the BAFF/APRIL system may constitute risk factors of B‐CLL – a preliminary study on a Polish population

et al. 2015

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The association of single-nucleotide polymorphisms (SNPs) of B-cell activating factor (BAFF)/a proliferation-inducing ligand (APRIL) system with B-cell chronic lymphocytic leukemia (B-CLL) have been suggested, therefore, we investigated 20 SNPs of BAFF, APRIL, BAFF-R, transmembrane activator and calcium modulator and cyclophilin-ligand interactor (TACI), B-cell maturation antigen (BCMA) genes and the risk and outcome of B-CLL in 187 patients and 296 healthy subjects as well as ligand-receptor gene × gene interactions. Although the obtained P-values for all 20 SNPs did not reach statistical significance for this study (α = 0.003), the high value of the global chi-squared statistic (χ(2) df = 38 = 52.65; P = 0.0586), and obtained values of odds ratio indicate that rs9514828 (BAFF), rs3803800 (APRIL) and rs4985726 (TACI) may be associated with the risk of B-CLL. We observed that the B-CLL patients with the genotype rs9514828CT/rs11570136AA were diagnosed with the disease 12 years later than the whole group of patients in this study.

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Polymorphisms in genes of the BAFF/APRIL system may constitute risk factors of B‐CLL – a preliminary study on a Polish population

et al. 2015

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“…A higher frequency of the minor T allele of the rs9514828 BAFF polymorphism in the high-risk SjS group for lymphoma was demonstrated [100]. Moreover, in SjS patients with younger-age onset (at <40 years old), the generalized odds ratio for the development of mucosa-associated tissue lymphoma was 6.1 in the presence of the BAFF-R His159Tyr mutation [101].…”

Section: Sjögren's Syndromementioning

confidence: 92%

The Roles of the TNF-Family Member B-Cell Activation Factor Belonging to the TNF-Family (BAFF) in Autoimmunity

Hirayama¹,

Nagai²

2017

Immunopathogenesis and Immune-Based Therapy for Selected Autoimmune Disorders

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The tumor necrosis factor superfamily (TNFSF) member and cytokine known as B-cell activation factor belonging to the TNF-family (BAFF) has been identified as one of the key factors in the selection and survival of B cells. Overexpression of BAFF in mice leads to autoimmunity, whereas BAFF-deficient mice lack mature B cells. Although under normal concentrations of BAFF, non-self-reactive B cells survived and autoreactive B cells were deleted, a higher concentration of BAFF contributed to the survival of autoreactive B cells and elevated autoantibody production. Lupus-prone mice have increased serum levels of BAFF during the onset and progression of disease. The serum BAFF levels are elevated in patients with autoimmune diseases, such as systemic lupus erythematosus, rheumatoid arthritis, Sjögren's syndrome and ANCA-associated vasculitis, and showed positive correlations with autoantibodies.

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“…Moreover, there is evidence that genetic variations underlying the differential expression of BAFF correlate with dissimilar propensity toward lymphoma evolution among pSS patients. The comparison between pSS patients with or without lymphoma, or well-established predictors of lymphoproliferation, namely parotid enlargement, purpura and low C4 complement levels, revealed significant differences in the prevalence of the AA genotype and specific haplotypes of the rs12583006 BAFF gene SNP [78]. The authors suggested that the interaction of pSS-related BAFF gene haplotypes together with distinct BAFF genetic variants appears to contribute to B-NHL development, suggesting the implication of the host's genetic background in pSS-related lymphomagenesis.…”

Section: Biologic Variances As Predictors Of Lymphoma Developmentmentioning

confidence: 98%

Predicting progression to lymphoma in Sjögren's syndrome patients

Giannouli

Voulgarelis

2014

Expert Review of Clinical Immunology

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Although the inherent complexity of the multifactorial nature of primary Sjögren's syndrome (pSS) renders the process of disease prognostication and prediction ambiguous, certain clinical and immunological characteristics have been described as lymphoma predictors in several studies. While the association between pSS and mucosa-associated lymphoid tissue lymphomas is indisputable, recent studies report a predominance of diffuse large B-cell lymphomas implying that pSS-lymphoma association is less subtype-specific than previously considered. The considerable differences in both disease severity and prognosis between patients with various types of lymphoma demand the identification of risk factors that can predict the development of the distinct subtypes. Additionally, a recently discovered diverse range of biological variables appears to influence clinical behavior and lymphoma outcome. In this review, we venture into the area of lymphoma prognostication in pSS, outlining long-established predictors, analyzing currently available prognostic models, and exploring the predictive potential of recent biological and molecular advances.

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B-cell activating factor genetic variants in lymphomagenesis associated with primary Sjogren's syndrome

Cited by 102 publications

References 39 publications

Polymorphisms in genes of the BAFF/APRIL system may constitute risk factors of B‐CLL – a preliminary study on a Polish population

Polymorphisms in genes of the BAFF/APRIL system may constitute risk factors of B‐CLL – a preliminary study on a Polish population

The Roles of the TNF-Family Member B-Cell Activation Factor Belonging to the TNF-Family (BAFF) in Autoimmunity

Predicting progression to lymphoma in Sjögren's syndrome patients

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