Bicyclic Phosphites

Acyclic to cyclic aminophosphonic and phosphinic acids

“…First of all, phosphorus heterocycles have proven that they are considerably more resistant to the ring opening/closure that occurs between the openchain and the cyclic forms of carboxylic lactone allowing the synthesis of more stable structures. 16 Moreover, the introduction of conformational constraints in amino acids or peptides also provides useful informations on structural requirements for bioactivities or even new active structures. 17 Then constrained or rigidified α-aminophosphinic acids possess original features:…”

Synthesis and Some Spectral Characteristics of Bicyclic Phosphate, GABA Antagonists

“…The other hydroxymethylated derivatives of alkylmalonates and a-alkylacetoacetates, as well as pivaloylmalonate, were reduced to the corresponding trio Is in a similar manner. (22). A solution of phosphoryl chloride (3.2g) in acetonitrile (10 ml) was added dropwise to a stirred solution of 5 (3.4 g) and pyridine (5.0 g) in acetonitrile (50 ml) cooled in an ice-bath.…”

Studies on the Biosynthesis of Antheridiol

“…resulting yellowish-green solution was added 10a (2.5 g ethyl trans-3,4-dimethyl-2-pentenoate, prepared from in THF, 4 ml), and the solution stirred for a further 20 h. acetic acid-1-14C (1.0 mC) by the method described (19), The solvent was removed it! cactro, water added to the resulted in the formation of (6) with a specific activity of residue.…”