Potential and Challenges in Application of Physiologically Based Pharmacokinetic Modeling in Predicting Diarrheal Disease Impact on Oral Drug Pharmacokinetics

Abstract

Word count of the introduction: 751 Word count of the minireview body (excluding introduction and conclusion): 8222 Word count of the minireview conclusion: 83 List of Non-standard Abbreviations: A amount of drug A d dissolved mass of drug A u undissolved mass of drug ACAT Advanced Compartment Absorption and Transit ADAM Advanced Dissolution Absorption Metabolism ASF absorption scale factor AUC area under the concentration-time curve BAD bile acid diarrhea BCRP Breast Cancer Resistance Protein BCS biopharmaceutics drug classes C l luminal drug concentration in the gut C max maximum concentration C s solubility of drug