B and C Types Natriuretic Peptides Modify Norepinephrine Uptake and Release in the Rat Adrenal Medulla

Vatta, Marcelo S.; Presas, M.F; Bianciotti, Liliana G.; Rodrı́guez-Fermepı́n, Martı́n; Ambros, R; Fernández, Belisario E.

doi:10.1016/s0196-9781(97)00244-1

Cited by 22 publications

(15 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The level of endogenous norepinephrine, a potent ␣1-stimulator, is highly elevated in sepsis (38), and also, the treatment of septic hypotension commonly includes norepinephrine. On the other hand, BNP can also regulate catecholamine secretion (39). We found a significant correlation between the dose of norepinephrine and NT-proBNP levels on the first day but not an independent effect in linear regression analysis.…”

Section: Discussionmentioning

confidence: 51%

Predictive value of N-terminal pro–brain natriuretic peptide in severe sepsis and septic shock*

Varpula

Pulkki²,

Karlsson³

et al. 2007

Critical Care Medicine

123

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 51%

Predictive value of N-terminal pro–brain natriuretic peptide in severe sepsis and septic shock*

Varpula

Pulkki²,

Karlsson³

et al. 2007

Critical Care Medicine

123

View full text Add to dashboard Cite

show abstract

“…Active metabolites of angiotensin have similar (eg, angiotensin III) or opposite (angiotensin 1-7) effects [5]. In contrast, atrial natriuretic peptide and type C natriuretic peptide increase sympathoinhibition and decrease the release of norepinephrine from nerve terminals [6]. Furthermore, both angiotensin II and atrial natriuretic peptide/type C natriuretic peptide have central effects that regulate sympathetic nervous system activity.…”

Section: Neurotransmitters and Neuropeptidesmentioning

confidence: 99%

The role of the nervous system in hypertension

Wyss

Carlson

2001

Current Science Inc

View full text Add to dashboard Cite

The central nervous system plays an important role in the minute-to-minute regulation of arterial pressure, but its contribution to chronic regulation of arterial pressure is less clear. A nervous system role in essential hypertension in humans has been postulated for decades, but conclusive data on the relationship has been lacking. However, several lines of evidence in animal models and in humans suggest that the sympathetic nervous system is a primary contributor to the development and maintenance of some forms of essential hypertension. The primary final common pathway for the nervous system's contribution to hypertension is the sympathetic nervous system. Sympathetic nervous system overactivity may result from either inappropriately elevated sympathetic drive from brain centers, an increase in synaptically released neurotransmitters in the periphery, or amplification of the neurotransmitter signal at the target tissue. This review examines recent evidence for the central and peripheral nervous systems' roles in hypertension, and considers recent findings in this area that suggest that sex steroids and circadian rhythms are important considerations in the nervous system's regulation of arterial pressure.

show abstract

“…In a similar fashion, ANP can modulate the metabolism of another catecholamine like noradrenaline, since it has been demonstrated that ANP increases norepinephrine uptake and its endogenous content and decreases its release, synthesis, and turnover and tyrosine hydroxylase activity at the hypothalamic presynaptic nerve ending level [56, 57]. The natriuretic peptides also regulate norepinephrine metabolism in the adrenal medulla [58]. Then, it is likely that ANP could regulate DA metabolism in the kidney as it does in the central nervous system and adrenal medulla.…”

Section: Regulation Of Renal Dopamine System By the Atrial Natriurmentioning

confidence: 99%

Atrial Natriuretic Peptide and Renal Dopaminergic System: A Positive Friendly Relationship?

Choi

Mikusic

Kouyoumdzian

et al. 2014

BioMed Research International

View full text Add to dashboard Cite

Sodium metabolism by the kidney is accomplished by an intricate interaction between signals from extrarenal and intrarenal sources and between antinatriuretic and natriuretic factors. Renal dopamine plays a central role in this interactive network. The natriuretic hormones, such as the atrial natriuretic peptide, mediate some of their effects by affecting the renal dopaminergic system. Renal dopaminergic tonus can be modulated at different steps of dopamine metabolism (synthesis, uptake, release, catabolism, and receptor sensitization) which can be regulated by the atrial natriuretic peptide. At tubular level, dopamine and atrial natriuretic peptide act together in a concerted manner to promote sodium excretion, especially through the overinhibition of Na+, K+-ATPase activity. In this way, different pathological scenarios where renal sodium excretion is dysregulated, as in nephrotic syndrome or hypertension, are associated with impaired action of renal dopamine and/or atrial natriuretic peptide, or as a result of impaired interaction between these two natriuretic systems. The aim of this review is to update and comment on the most recent evidences demonstrating how the renal dopaminergic system interacts with atrial natriuretic peptide to control renal physiology and blood pressure through different regulatory pathways.

show abstract

B and C Types Natriuretic Peptides Modify Norepinephrine Uptake and Release in the Rat Adrenal Medulla

Cited by 22 publications

References 41 publications

Predictive value of N-terminal pro–brain natriuretic peptide in severe sepsis and septic shock*

Predictive value of N-terminal pro–brain natriuretic peptide in severe sepsis and septic shock*

The role of the nervous system in hypertension

Atrial Natriuretic Peptide and Renal Dopaminergic System: A Positive Friendly Relationship?

Contact Info

Product

Resources

About