B and C terms in the Van Deemter equation for liquid chromatography

Comparison of the kinetic performance and retentivity of sub-2μm core–shell, hybrid and conventional bare silica phases in hydrophilic interaction chromatography

“…After each park time, the flow is resumed, the analyte band is eluted from the column and the peak variance is measured. The additional peak broadening that takes place in the parking period is given by [14,29]  2 z = 2 Deff.t park (3) where  z is measured in units of column length.…”

Theory and Practice of UHPLC and UHPLC–MS

“…In general, the b-term plate height contribution (h b ) is linked to the effective longitudinal diffusion coefficient (D eff ) by Giddings (1965b) and Knox and Scott (1983):…”

“…The effective diffusion coefficient D eff is related to the diffusion in the mobile phase, D m , and the diffusion inside the particle, D part (or in the porous zone, D pz ). Based on Giddings' (1965b) work, Knox and Scott (1983) had proposed a residence time weighted (RTW) model to describe the combined diffusion in both phases, which has been in use until recently. , however, demonstrated that the RTW model was not able to represent simulated and experimental D eff /D m values across a large range of retention factors.…”

Modelling the relation between the species retention factor and the C‐term band broadening in pressure‐driven and electrically driven flows through perfectly ordered 2‐D chromatographic media

“…(A1a). The H B -term represents the band broadening in the absence of any flow and is therefore linked to D eff , the effective longitudinal diffusion coefficient, reflecting the combined effect of the diffusion inside and outside the particles [16,54]. Traditionally, it is assumed that these diffusion contributions are independent of each other, so that the effective diffusion coefficient can simply be calculated as their time-weighted average, which can be expressed as:…”

“…Interestingly, the mobile zone volume V por appears in the expression for H Cm as well as in that for H Cs . The zone retention factor k 00 (which differs from the more frequently used phase retention factor k 0 [54,56]) represents the number of times a given type of species stays longer in the system than a species that is not capable of entering the meso-porous pillar zones, and can be defined as:…”