B and C hepatitis viruses, HLA-DQ1 and -DR3 alleles and autoimmunity in patients with hepatocellular carcinoma

Pellegris, G; Ravagnani, Fernando; Notti, P.; Fissi, S.; Lombardo, Claudia

doi:10.1016/s0168-8278(02)00002-8

Cited by 13 publications

(9 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This variability in outcome following exposure, and the clustering of HCC within families, raise the possibility that genetic factors are also involved in susceptibility to HCC. Major histocompatibility complex (MHC) plays a key role in anti-virus and tumor defense (Pellegris et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

HLA-Class II Alleles in Egyptian Patients with Hepatocellular Carcinoma

El-Chennawi

Auf

Metwally

et al. 2008

Immunological Investigations

View full text Add to dashboard Cite

1. A significantly increased frequency of DRB1*04, and DQB1 *02 in HCC patients versus control group (p = 0.016, and 0.032, respectively) was found; 2. A significantly decreased frequency of DQB1*06 (p = 0.032) was found; 3. A significantly increased frequency of DRB1*07 (odds ratio (OR) = 4.929) was found; and 4. A significantly decreased frequency of DRB1*15 (OR = 0.316) was seen. In conclusion, while some alleles are significantly associated with HCC (DRB1*04, DQB1*02) and others are not associated (DQB1*06); therefore, it can be concluded that the DRB1*04 and DQB1*02 alleles might be risk factors for the occurrence of HCC (OR = 4.373 and 3.807, respectively), and DQB1*06 may be a protective allele (OR = 0.259).

show abstract

Section: Discussionmentioning

confidence: 99%

HLA-Class II Alleles in Egyptian Patients with Hepatocellular Carcinoma

El-Chennawi

Auf

Metwally

et al. 2008

Immunological Investigations

View full text Add to dashboard Cite

show abstract

“…Conversely, little information is available on the possible association between HLA alleles and specific cancers (i.e., HCC or NHL, in patients carrying HCV but not hepatitis B virus [HBV] or human immunodeficiency virus [HIV] infections) [16,17].…”

Section: Introductionmentioning

confidence: 99%

Hepatitis C virus-related hepatocellular carcinoma and B-cell lymphoma patients show a different profile of major histocompatibility complex class II alleles

Caggiari

Talamini

et al. 2004

Human Immunology

View full text Add to dashboard Cite

“…However, mostly, the results were inconsistent due to disparities in the study design, sample size and ethnicity. Many researchers have investigated the association of HLA genes with HBV-related HCC1314151617. There is a paucity of Indian HLA studies in these patients.…”

mentioning

confidence: 99%

HLA-DQA1 & DQB1 variants associated with hepatitis B virus-related chronic hepatitis, cirrhosis & hepatocellular carcinoma

et al. 2018

View full text Add to dashboard Cite

Background & objectives:Clinical outcome after hepatitis B virus (HBV) exposure varies extremely from spontaneous clearance to chronic hepatitis B and often progresses to liver cirrhosis (LC) and hepatocellular carcinoma (HCC). Host genetic factor plays an important role in the regulation of immune response. This study was aimed to investigate whether HLA class II DQA1 and DQB1 gene polymorphism were associated with chronic hepatitis B infection and in the development of HBV-related LC and HCC.Methods:DQA1 and DQB1 allele polymorphism were studied in 187 patients with HBV-related liver diseases (which included 73 chronic hepatitis B, 84 LC and 30 HCC patients) and 109 controls who had spontaneously recovered from HBV infection using polymerase chain reaction amplification with sequence-specific primers.Results:Our data suggested that DQA1*0101/2/4 [odds ratio (OR)=2.78; Pc=0.003], DQA1*0103 (OR=2.64; Pc=0.0007) and DQB1*0302/3 (OR=2.15; Pc=0.01) were associated with the protection from chronic HBV infection, whereas DQB1*0402 (OR=0.25; Pc=0.001) showed susceptible effect on chronic HBV infection. DQB1*0601 (OR=3.73; Pc=0.006) conferred protective effect from developing LC; similarly, DQB1*0302/3 (OR=5.53; Pc=0.05) and DQB1*0402 (OR=0.00; Pc=0.001) conferred protective effect from developing HCC. However, DQA1*0601 and DQB1*0503 showed susceptible effect on chronic HBV infection; these associations were no longer significant after Bonferroni correction.Interpretation & conclusions:Our results revealed HLA-DQA1*0101/2/4 - DQA1*0103 - DQB1*0302/3 and DQB1*0601 as protective and DQB1*0402 as risk alleles. The study suggests that various subtypes of HLA-DQA1 and DQB1 are associated with both HBV clearance and development of chronic HBV infections.

show abstract

B and C hepatitis viruses, HLA-DQ1 and -DR3 alleles and autoimmunity in patients with hepatocellular carcinoma

Cited by 13 publications

References 37 publications

HLA-Class II Alleles in Egyptian Patients with Hepatocellular Carcinoma

HLA-Class II Alleles in Egyptian Patients with Hepatocellular Carcinoma

Hepatitis C virus-related hepatocellular carcinoma and B-cell lymphoma patients show a different profile of major histocompatibility complex class II alleles

HLA-DQA1 & DQB1 variants associated with hepatitis B virus-related chronic hepatitis, cirrhosis & hepatocellular carcinoma

Contact Info

Product

Resources

About