B-69 * Cognitive Performance as a Function of Low-Frequency, Repetitive Transcranial Magnetic Stimulation Administration to the Right Dorsolateral Prefrontal Cortex and Supplementary Motor Area

Chappell, Ann M.; Seagly, Katharine; Okwara, L; Bayan, S; Sayegh, Patricia F.; Neumann, S.

doi:10.1093/arclin/acu038.157

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“… 20 21 Previous studies with low-frequency rTMS applied over the right dorsolateral prefrontal cortex (DLPFC) have shown a significant increase in the connectivity and reorganisation of the brain network and improvement of cognitive performance. 22 23 …”

Section: Introductionmentioning

confidence: 99%

Treatment of postoperative delirium with continuous theta burst stimulation: study protocol for a randomised controlled trial

Wei

Wang

et al. 2021

BMJ Open

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IntroductionPostoperative delirium is one of the most common postoperative complications among elderly patients (65 years old or older). However, there are no effective treatments for this condition. Recent research suggests that continuous theta burst stimulation (cTBS), a non-invasive brain stimulation, can reduce pain level, improve cognitive function and affective symptoms in multiple diseases or dysfunctions, including anxiety disorders, major depressive disorder, sleep disorders and pain. But the potential benefits of cTBS in reducing postoperative delirium have not been investigated. Therefore, we propose determining whether cTBS can prevent and/or treat postoperative delirium in senior patients.Methods and analysisThe study will be a double-blind, randomised controlled trial. Participants (65 years old or older) undergoing scheduled orthopaedic surgery (≥2 hours, general anaesthesia) will be randomised to receive either cTBS or sham stimulation with a focal figure-of-eight coil over the right dorsolateral prefrontal cortex at 80% of the resting motor threshold. Every patient will receive 2–3 sets of stimulations during postoperative days (40 s per session, 3 sessions per set, 1 set per day). Participants will be assessed twice daily by a research assistant blinded to allocation. The primary outcome will be the incidence of postoperative delirium measured by the Confusion Assessment Method on postoperative days 1, 2 and 3. The secondary outcomes will be the severity and duration of postoperative delirium, cognitive function, pain, sleep quality, activities of daily living, length of hospital stay, discharge-to-facility or home, and rate of complication and mortality during the hospital stay.Ethics and disseminationEthical approval has been obtained from the ethics committee of Shanghai 10th People’s Hospital. The principal investigator will submit a research progress report to the ethics committee regularly. All participants will provide written informed consent. Study results will be published in a peer-reviewed journal.Trial registration numberNCT04661904.

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Section: Introductionmentioning

confidence: 99%