Aβ1-42 stimulates an increase in autophagic activity through tunicamycin-induced endoplasmic reticulum stress in HTR-8/SVneo cells and pre-eclampsia
Qian Gao,
Kai Cheng,
Leiming Cai
et al.
Abstract:Environmental changes can trigger endoplasmic reticulum (ER) stress and misfolded protein accumulation, potentially leading to Pre-eclampsia (PE). Amyloid-β (Aβ) is a crucial misfolded protein that can overactivate autophagy. Our study assessed the expression of Aβ1−42 and autophagic activity in PE placental tissues and trophoblasts under ER stress. Placental tissues were surgically collected from normal pregnant women (NP) and pregnant women with PE delivering through cesarean section. The expression levels o… Show more
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