Abstract:Background: Accumulation of β-amyloid is a major pathology of Alzheimer's disease (AD). As in other neurodegenerative diseases, it is also reported that proteasome activity is deteriorated in post-mortem brains of AD patients. However, the mechanism of proteasomal dysfunction in AD remains unexplained. There is, however, increasing reported evidence that the unfolded protein response (UPR) is involved in AD pathology. Here we show that Aβ causes not only the UPR leading to endoplasmic reticulum (ER) stress med… Show more
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