Aβ-Associated cerebral angiopathy and senile plaques with neurofibrillary tangles and cerebral hemorrhage in an aged wolverine (Gulo gulo)

Roertgen, K. E.; Parisi, Joseph E.; Clark, H. Brent; Barnes, Donald L.; O’Brien, Timothy; Johnson, Kenneth H.

doi:10.1016/0197-4580(95)02069-1

Cited by 59 publications

(37 citation statements)

References 29 publications

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“…35,63,135,152,160,161 Typically these tau changes tend to be sporadic and do not adopt the full blown features of intracellular NFTs and are usually not associated with neuronal loss. Interestingly, even in nonhuman primates, which display substantial plaques formation and tau proteins with highly conserved amino acid sequences, NFT are rarely observed.…”

Section: Neuronal Lesionsmentioning

confidence: 99%

Pathology of the Aging Brain in Domestic and Laboratory Animals, and Animal Models of Human Neurodegenerative Diseases

et al. 2016

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According to the WHO, the proportion of people over 60 years is increasing and expected to reach 22% of total world's population in 2050. In parallel, recent animal demographic studies have shown that the life expectancy of pet dogs and cats is increasing. Brain aging is associated not only with molecular and morphological changes but also leads to different degrees of behavioral and cognitive dysfunction. Common age-related brain lesions in humans include brain atrophy, neuronal loss, amyloid plaques, cerebrovascular amyloid angiopathy, vascular mineralization, neurofibrillary tangles, meningeal osseous metaplasia, and accumulation of lipofuscin. In aging humans, the most common neurodegenerative disorder is Alzheimer's disease (AD), which progressively impairs cognition, behavior, and quality of life. Pathologic changes comparable to the lesions of AD are described in several other animal species, although their clinical significance and effect on cognitive function are poorly documented. This review describes the commonly reported age-associated neurologic lesions in domestic and laboratory animals and the relationship of these lesions to cognitive dysfunction. Also described are the comparative interspecies similarities and differences to AD and other human neurodegenerative diseases including Parkinson's disease and progressive supranuclear palsy, and the spontaneous and transgenic animal models of these diseases.

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Section: Neuronal Lesionsmentioning

confidence: 99%

Pathology of the Aging Brain in Domestic and Laboratory Animals, and Animal Models of Human Neurodegenerative Diseases

et al. 2016

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“…Most affected neurons have been identified as pyramidal neurons of the hippocampus and entorhinal cortex [42][43][44][45][46][47][48][49][50][51][52]. These findings suggest a selective vulnerability of this brain region and anatomical conservation of the disease progression in various animal species.…”

Section: Spreading Of Pathology In Tauopathies -The Inside Storymentioning

confidence: 65%

Transmission of Tau Pathology from Human to Rodent Brain: How to Humanise Animal Models for Alzheimer’s Disease Research

Smolek¹,

Jadhav²,

Valachova³

et al. 2017

J Alzheimers Dis Parkinsonism

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“…animals (a chimpanzee and a wolverine) have been reported to exhibit both argyrophilic NFTs and Ab deposits. 42,43 Nevertheless, we detected abnormally phosphorylated tau in the brains of 10 aged cheetahs (which lived over 10 years) and NFTs in 6 aged cheetahs with diffuse Ab deposits in the cerebrum.…”

Section: Discussionmentioning

confidence: 97%

“…5 To our knowledge, the presence of Ab deposits and NFTs in the same individual has been detected in only 1 wolverine and 1 chimpanzee. 42,43 Since both of these were only case reports and intracranial infarction or hemorrhage was present in each and may have been the primary lesion responsible for NFTs, it remains unclear whether both findings of AD (NFTs and Ab deposits) spontaneously developed in these cases. Some researchers assume that AD is not present in animals because they do not live long enough to develop this slow-progressing disease.…”

mentioning

confidence: 99%

“…Ab deposits and accumulation of abnormally phosphorylated tau have been described in the brains of a variety of species. 6,[17][18][19] However, argyrophilic NFTs have been reported in few species, including the chimpanzee, 43 wolverine, 42 Asiatic brown bear, 7 sheep, and goat. 5 To our knowledge, the presence of Ab deposits and NFTs in the same individual has been detected in only 1 wolverine and 1 chimpanzee.…”

mentioning

confidence: 99%

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Beta Amyloid Deposition and Neurofibrillary Tangles Spontaneously Occur in the Brains of Captive Cheetahs (Acinonyx jubatus)

2011

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Alzheimer disease is a dementing disorder characterized pathologically by Ab deposition, neurofibrillary tangles, and neuronal loss. Although aged animals of many species spontaneously develop Ab deposits, only 2 species (chimpanzee and wolverine) have been reported to develop Ab deposits and neurofibrillary tangles in the same individual. Here, the authors demonstrate the spontaneous occurrence of Ab deposits and neurofibrillary tangles in captive cheetahs (Acinonyx jubatus). Among 22 cheetahs examined in this study, Ab deposits were observed in 13. Immunostaining (AT8) revealed abnormal intracellular tau immunoreactivity in 10 of the cheetahs with Ab deposits, and they were mainly distributed in the parahippocampal cortex and CA1 in a fashion similar to that in human patients with Alzheimer disease. Ultrastructurally, bundles of straight filaments filled the neuronal somata and axons, consistent with tangles. Interestingly, 2 of the cheetahs with the most severe abnormal tau immunoreactivity showed clinical cognitive dysfunction. The authors conclude that cheetahs spontaneously develop age-related neurodegenerative disease with pathologic changes similar to Alzheimer disease.

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Aβ-Associated cerebral angiopathy and senile plaques with neurofibrillary tangles and cerebral hemorrhage in an aged wolverine (Gulo gulo)

Cited by 59 publications

References 29 publications

Pathology of the Aging Brain in Domestic and Laboratory Animals, and Animal Models of Human Neurodegenerative Diseases

Pathology of the Aging Brain in Domestic and Laboratory Animals, and Animal Models of Human Neurodegenerative Diseases

Transmission of Tau Pathology from Human to Rodent Brain: How to Humanise Animal Models for Alzheimer’s Disease Research

Beta Amyloid Deposition and Neurofibrillary Tangles Spontaneously Occur in the Brains of Captive Cheetahs (Acinonyx jubatus)

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