Azulene incorporation and release by hydrogel containing methacrylamide propyltrimenthylammonium chloride, and its application to soft contact lens

Uchida, Rei; Sato, Takao; Tanigawa, Haruyasu; Uno, Kenji

doi:10.1016/s0168-3659(03)00368-7

Cited by 78 publications

(46 citation statements)

References 6 publications

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“…18,19 An ion ligand is a bond in which an ion binds to a central metal atom to form a coordination complex. Contact lenses with a drug delivery system can be designed to contain the required …”

Section: Discussionmentioning

confidence: 99%

“…[17][18][19] In previous studies, a drug delivery hydrogel material consisting of 2-hydroxyethyl methacrylate (HEMA) was used as the main material, ethyleneglycole dimethacrylate (EGDMA) as a crosslinking agent, methacrylamide (MAm) as a functional group, and methacrylic acid or phosphoric acid as an anionic material group. 17,18 The polymer-drug interaction between phosphoric acid as an anionic material, and naphazoline as a cationic drug 19 was also studied, and it was found that HEMA, EGDMA, and MAm were required, since both cationic and anionic monomers are essential to a synthesized drug delivery hydrogel SCL. The reason for this is that the hydrogel material is not able to maintain the strength and the shape necessary for an SCL if either a cationic or anionic monomer was not included.…”

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confidence: 99%

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Development and Efficacy of a Drug-Releasing Soft Contact Lens

Kakisu

Matsunaga²,

Kobayakawa

et al. 2013

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. The purpose of this study was to investigate the uptake and the release of antibiotics from a newly synthesized drug delivery hydrogel soft contact lens (SCL) using an ion ligand mechanism.METHODS. The antibiotics used were Gatifloxacin (GFLX) and Moxifloxacin (MFLX). The uptake amount and the sustained-release kinetics of antibiotics were investigated in vitro, and were also compared with newly synthesized SCLs, etafilcon A and polymacon. The antibiotic concentrations in the cornea, aqueous humor, and crystalline lens, and the effect against bacterial proliferation were investigated in vivo using rabbit subjects. Additionally the drug release efficacy of the new SCL was compared with that of eye drop administrations.RESULTS. In vitro, antibiotic uptake was increased with the weight percent (wt%) of the anionic group, and the released amount of antibiotics was highest during the initial 1 hour period, which then decreased over the next 72 hours. The released antibiotics volume of the new SCLs was significantly higher throughout 72 hours than that of the other two materials, etafilcon A and polymacon (P < 0.01). Whereas in vivo, the concentrations found in the cornea and aqueous humor were higher than those for the eye drop groups (P < 0.05 or P < 0.01). Antibiotic release at those sites decreased over 72 hours. No bacterial populations were detectable in the group treated with the new SCL presoaked in antibiotics throughout the experimental periods. CONCLUSIONS.The new SCLs released the antibiotics over several days, and showed improved penetration into the eye, along with prevention of bacterial proliferation.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Development and Efficacy of a Drug-Releasing Soft Contact Lens

Kakisu

Matsunaga²,

Kobayakawa

et al. 2013

Invest. Ophthalmol. Vis. Sci.

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“…Soft contact lens-based DDSs have been investigated by several approaches: (1) Soak and absorption of drug solution [86]; (2) piggyback contact lens combined with a drug plate or drug solution [87]; (3) surface-modification to immobilize drugs on the surface of contact lenses [88]; (4) incorporation of drugs in a colloidal structure dispersed in the lens [89]; (5) ion ligand-containing polymeric hydrogel [90]; and (6) molecularly imprinting of drugs [91,92].…”

Section: Contact Lensmentioning

confidence: 99%

Recent Advances in Ocular Drug Delivery Systems

2011

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Abstract:Transport of drugs applied by traditional dosage forms is restricted to the eye, and therapeutic drug concentrations in the target tissues are not maintained for a long duration since the eyes are protected by a unique anatomy and physiology. For the treatment of the anterior segment of the eye, various droppable products to prolong the retention time on the ocular surface have been introduced in the market. On the other hand, direct intravitreal implants, using biodegradable or non-biodegradable polymer technology, have been widely investigated for the treatment of chronic vitreoretinal diseases. There is urgent need to develop ocular drug delivery systems which provide controlled release for the treatment of chronic diseases, and increase patient's and doctor's convenience to reduce the dosing frequency and invasive treatment. In this article, progress of ocular drug delivery systems under clinical trials and in late experimental stage is reviewed.

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“…For comparison, Smopex DS-218v fiber demonstrated a higher loading of SA (1.4 mmol/g) previously 15,16 than in the present study (0.98 mmol/g), as the capacity of the fiber in the previous batches was nearly twofold higher. Uchida et al 28 observed that the molar amount of azulene incorporated into cationic hydrogels was higher as the amount of functional ion-exchange groups (ÀN(CH 3 ) 3 ) in the gels was increased, while the relative occupancy remained constant ($100%). The results support the assumption that the compounds are incorporated to the fibers primarily via ionexchange and, thus, enable easy manipulation of molar drug content in the fibers.…”

Section: Capacity Of Ion-exchange Fibersmentioning

confidence: 99%