AZT oxidative damage in the liver

Butanda-Ochoa, Armando; Ayhllon-Osorio, Carlos Alberto; Hernández‐Muñoz, Rolando

doi:10.1016/b978-0-12-819092-0.00029-7

Cited by 1 publication

(1 citation statement)

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“…The mitochondrial toxicity of AZT is due to mitochondrial DNA damage caused by increased reactive oxygen species (Premanathan et al, 1997). An in-depth analysis performed by Butanda-Ochoa and colleagues demonstrated that AZT-mediated toxicity impairs mitochondrial function leading to increased ROS levels and oxidative stress in muscles and especially in the liver (Butanda-Ochoa et al, 2021). More recently, a study performed metabolic profiling of the sera of HIV-infected patients with an AZT-based antiretroviral treatment.…”

Section: Azidothymidine Treatment Potentiates Hiv-derived Oxidative S...mentioning

confidence: 99%

Redox medicine in viral infections: focus on AIDS and COVID-19

Mas-Bargues

Borrás

Viña

2022

Redox Experimental Medicine

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Despite the great progress and advancements in scientific knowledge, technology, and medicine, viral infections continue to put human health in trouble. Both acquired immunodeficiency syndrome (AIDS) and coronavirus disease-2019 (COVID-19), caused by HIV and SARS-CoV-2, two RNA viruses responsible for global pandemics respectively, have poor outcomes associated with increased oxidative stress, systemic inflammation, and immunopathology. Here, we have collected the current knowledge linking both viral infections, focusing on the role of oxidative stress and the redox balance. Furthermore, we provide information on some redox-active compounds, such as vitamins, thiol-based agents, and polyphenols, and their possible beneficial effects on both diseases. Thus, in this review, we aim to highlight the importance and impact of nutritional strategies to strengthen our immune system, especially to increase the effectiveness of pharmacological treatments, or when there are no effective treatments.

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Section: Azidothymidine Treatment Potentiates Hiv-derived Oxidative S...mentioning

confidence: 99%