Azoospermie non obstructive : intérêt du prélèvement testiculaire synchrone du recueil ovocytaire

Grynberg, M.; Chevalier, Nicolas; Mesner, A.; Rocher, Laurence; Prisant, Nadia; Madoux, S.; Feyereisen, E.; Ferlicot, Sophie; Fanchin, Rénato; Frydman, René; Frydman, Nelly; Izard, V.

doi:10.1016/j.jgyn.2010.11.003

Cited by 6 publications

(3 citation statements)

References 30 publications

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“…MicroTESE appears to improve the frequency of successful sperm retrieval and is suggested to be the standard of the management for NOA [19–25]. However, because spermatogenesis is limited in NOA patients, surgical sperm-retrieval rates are between 36%-64% [19, 26]. Although several micro-surgical methods can improve surgical sperm retrieval rates [27–30], failure of spermatozoa retrieval is still possible.…”

Section: Discussionmentioning

confidence: 99%

Failed sperm retrieval from severely oligospermic or non-obstructive azoospermic patients on oocyte retrieval day: Emergent oocyte cryopreservation is a feasible strategy

Lin

Huang²,

Chen³

et al. 2019

PLoS ONE

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PurposeUnexpected sperm retrieval failure on the day of oocyte retrieval is not common but frequently happened in patients with severe oligospermia or non-obstructive azoospermia(NOA). Oocyte cryopreservation is a common strategy after failed collection of sperm when concurrent ovarian stimulation is underwent. However, the use of oocyte vitrification in such male-infertility cases remains unclear.ObjectiveTo investigate the outcomes of emergent oocyte cryopreservation after failed sperm retrieval from severe oligospermic or non-obstructive azoospermic (NOA) patients on oocyte retrieval day.MethodsDesign: Retrospective cohort studySetting: Academic fertility center at Lee Women's Hospital, Taiwan, between March 2015 and August 2017.Patients: For 203 couples with NOA(n = 200) or severe oligospermia(n = 3), testicular spermatozoa (n = 67 cycles) or frozen donor sperm (n = 209 cycles) were injected into fresh or frozen-thawed oocytes via 276 intracytoplasmic sperm injection (ICSI) cycles.Main Outcome Measures: Clinical pregnancy and live-birth rates (LBRs).ResultsIn the 67 cycles involving the use of fresh testicular spermatozoa, no significant differences were observed between fresh and warmed oocytes with respect to the fertilization rates (69.2% vs. 74.1%; p = 0.27), number of Day-3 embryos (8.6±4.4 vs. 6.4±3.4; p = 0.08), number of good-quality Day-3 embryos (4.5±3.9vs. 4.7±3.0; p = 0.45), implantation rates (29.1% vs. 17.8%; p = 0.21), clinical pregnancy rates (36.4% vs. 26.8.0%; p = 0.81), live birth rates (36.4% vs. 14.3%; p = 0.46), or perinatal outcomes. In the 209 cycles involving the use of frozen donor sperm, no significant differences were seen between the two groups, except that the mean birth weights were significantly lower with fresh oocyte pregnancies than with warmed oocytes (2952±196 gm vs 2643±700 gm; p = 0.006).ConclusionsEmergent oocyte cryopreservation is a feasible strategy to manage unexpected sperm retrieval failure from severe oligospermic or NOA patients on the oocyte retrieval day. There is no detrimental effect on the live birth rate when testicular spermatozoa or frozen donor sperm are injected into the thawed oocytes compared with fresh oocytes.

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Section: Discussionmentioning

confidence: 99%

Failed sperm retrieval from severely oligospermic or non-obstructive azoospermic patients on oocyte retrieval day: Emergent oocyte cryopreservation is a feasible strategy

Lin

Huang²,

Chen³

et al. 2019

PLoS ONE

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“…En effet, la fécondation assistée peut être synchrone ou différée à la biopsie testiculaire. Deux attitudes s'opposent : les tenants de la biopsie exploratrice avec congélation cherchent à évi-ter une stimulation inutile chez la partenaire en cas de ponction blanche chez l'homme ; les défenseurs de l'ICSI synchrone préfèrent prendre ce risque car, lorsque la spermatogenèse est altérée, le rendement de la congélation est moins bon qu'en cas de sperme frais [5].…”

Section: Discussionunclassified

“…Le transfert de deux embryons de grade I, à j2, appuie notre conduite [5]. Notre décision était en accord avec Aoki et al [6] qui, en 2004, ont rapporté dans leur étude un meilleur taux de fécondation et d'obtention d'embryons de bonne qualité avec des biopsies testiculaires synchrones dans le cas d'une extraction d'un faible nombre de spermatozoïdes immobiles.…”

Section: Discussionunclassified

Intérêt du prélèvement testiculaire synchrone pour une azoospermie non obstructive à FSH très élevée

Merdassi¹,

Elloumi²,

Kdous³

et al. 2011

Immuno-analyse & Biologie Spécialisée

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Indications et techniques des prélèvements testiculaires et épididymaires

Izard

2023

Infertilité

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Azoospermie non obstructive : intérêt du prélèvement testiculaire synchrone du recueil ovocytaire

Cited by 6 publications

References 30 publications

Failed sperm retrieval from severely oligospermic or non-obstructive azoospermic patients on oocyte retrieval day: Emergent oocyte cryopreservation is a feasible strategy

Failed sperm retrieval from severely oligospermic or non-obstructive azoospermic patients on oocyte retrieval day: Emergent oocyte cryopreservation is a feasible strategy

Intérêt du prélèvement testiculaire synchrone pour une azoospermie non obstructive à FSH très élevée

Indications et techniques des prélèvements testiculaires et épididymaires

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