Azomethine ylide addition impact on functionalized [60]Fullerene and [60]Boron-Nitride: Anticancer Doxorubicin and Boronic Chalcone drugs binding characteristics with mono- and bis-nanocarriers

Omri, Nabil; Bu, Yuxiang

doi:10.1016/j.colsurfb.2020.111277

Cited by 8 publications

(4 citation statements)

References 42 publications

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“…It is presumed that elements will influence several curdling factors within the body. The element plays a very important role in the improvement of bones [157] because it is useful in chemical reactions occurring inside the body [158] and rebirth [157] of bones. Boron plays an important role in bone mineralization and proliferation [159].…”

Section: Properties and Applications Bone Mineralization And Prolifer...mentioning

confidence: 99%

A Review on the Recent Advancements on Therapeutic Effects of Ions in the Physiological Environments

et al. 2022

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This review focuses on the therapeutic effects of ions when released in physiological environments. Recent studies have shown that metallic ions like Ag+, Sr2+, Mg2+, Mn2+, Cu2+, Ca2+, P+5, etc., have shown promising results in drug delivery systems and regenerative medicine. These metallic ions can be loaded in nanoparticles, mesoporous bioactive glass nanoparticles (MBGNs), hydroxyapatite (HA), calcium phosphates, polymeric coatings, and salt solutions. The metallic ions can exhibit different functions in the physiological environment such as antibacterial, antiviral, anticancer, bioactive, biocompatible, and angiogenic effects. Furthermore, the metals/metalloid ions can be loaded into scaffolds to improve osteoblast proliferation, differentiation, bone development, fibroblast growth, and improved wound healing efficacy. Moreover, different ions possess different therapeutic limits. Therefore, further mechanisms need to be developed for the highly controlled and sustained release of these ions. This review paper summarizes the recent progress in the use of metallic/metalloid ions in regenerative medicine and encourages further study of ions as a solution to cure diseases.

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Section: Properties and Applications Bone Mineralization And Prolifer...mentioning

confidence: 99%

A Review on the Recent Advancements on Therapeutic Effects of Ions in the Physiological Environments

et al. 2022

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“…It encounters Mg, calciferol, and metallic element, all that serves a very crucial role in the metabolic activities of bone [155]. Bortezomib (PS-341), trade name Velcade, is a boron compound from Millennium Pharmaceuticals (now Takeda Pharmaceutical) and is the first proteasome inhibitor approved for the treatment of newly diagnosed MM, relapsed/refractory MM, and mantle cell lymphoma [160]. It is a dipeptide boronic acid derivative that contains pyrazines acid, phenylalanine, and leucine with boronic acid.…”

Section: Boronmentioning

confidence: 99%

A Review on the Recent Advancements on Therapeutic Effects of Metallic Ions in the Physiological Environments

Awais¹,

Aziz²,

Nazneen³

et al. 2022

Preprint

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This review focuses on the therapeutic effects of metallic ions when released in physiological environments. Recent studies have shown that metallic ions like Ag+, Sr2+, Mg2+, Mn2+, Cu2+, Ca2+, P+5, etc., have shown promising results in drug delivery systems and regenerative medicine. These metallic ions can be loaded in nanoparticles, mesoporous bioactive glass nanoparticles (MBGNs), hydroxyapatite (HA), calcium phosphates, polymeric coatings, and salt solutions. The metallic ions can exhibit different functions in the physiological environment such as antibacterial, antiviral, anti-cancer, bioactive, biocompatible, and angiogenic effect. Furthermore, the metallic ions can be loaded in scaffolds to improve osteoblast proliferation, differentiation, bone development, fibroblast growth, and improved wound healing efficacy. Moreover, different metallic ions possess different therapeutic limits. Therefore, further mechanisms need to be developed for the highly controlled and sustained release of these ions. This review paper summarizes the recent progress in the use of metallic ions in regenerative medicine and encourages further study of metallic ions as a solution to cure diseases.

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“…It is worth noting that all these studies focused on the effect of single carbon doping, mainly incorporated as C B defect, in the properties of the BNF. However, very few reports can be found considering multiple carbon substitutions [38,39] or the different possible isomers. [40] Here, we present a theoretical study in the frame of the density functional theory (DFT) of the effect of carbon doping on the structural and physicochemical properties of B 12 N 12-x C x [4,6]-fullerenes (0 ≤ x ≤ 6).…”

Section: Introductionmentioning

confidence: 99%

Structural and Physicochemical Properties of Carbon Doped Boron Nitride Fullerenes: Effect of Doping Level and Atomic Arrangement

Escobedo‐Morales,

Salazar‐Villanueva,

Guatemala‐Vera

et al. 2023

Advcd Theory and Sims

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The effect of carbon doping on the structural and physicochemical properties of B12N12‐xCx [4, 6]‐fullerenes (0 ≤ x ≤ 6) (BNFs) is studied in the frame of the density functional theory. All non‐symmetry related isomers are modeled. Although carbon doping reduces the cohesive energy of the BNFs, most of them remain stable. It is found that the location of carbon atoms in the lowest‐energy isomers follows a definite sequence as the doping level increases. The results indicate that substitutional carbon lowers the gap energy and chemical hardness of BNFs, but it increases their electronegativity and electrophilicity index. Particularly, carbon doping makes BNFs more susceptible to nucleophilic attacks. Additionally, the charge redistribution and structural asymmetry generated by carbon doping endows BNFs with polar character. A dipole alignment parameter is introduced to elucidate some correlation between the atomic arrangement and the polarity of the systems. While carbon doping enhances the capability of BNFs to interact with other chemical species, possible toxicity concerns are highlighted. Finally, possible fingerprints to identify successful carbon doping through infrared and UV–vis spectroscopy are proposed.

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Azomethine ylide addition impact on functionalized [60]Fullerene and [60]Boron-Nitride: Anticancer Doxorubicin and Boronic Chalcone drugs binding characteristics with mono- and bis-nanocarriers

Cited by 8 publications

References 42 publications

A Review on the Recent Advancements on Therapeutic Effects of Ions in the Physiological Environments

A Review on the Recent Advancements on Therapeutic Effects of Ions in the Physiological Environments

A Review on the Recent Advancements on Therapeutic Effects of Metallic Ions in the Physiological Environments

Structural and Physicochemical Properties of Carbon Doped Boron Nitride Fullerenes: Effect of Doping Level and Atomic Arrangement

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