Azolyl pyrimidines-synthesis and antimicrobial activity

Abstract

Amide unit is a privileged structural motif and is a constituent of proteins, natural products and pharmaceuticals.Amongst different heterocyclic scaffolds, azoles and pyrimidines are the prominent entities in pharmaceutical arena. The biopotency of these heterocycles have triggered to synthesize a variety of heteroaromatics-azoles linked with pyridines by amino acetamide group. The target molecules-azolylaminoacetamidopyrimidines were prepared by the reaction of methyl azolylglycinate with pyrimidinyl-2-amine in the presence of DMAP and triethylamine in dichloromethane under ultrasonication.The lead molecules were evaluated for antimicrobial activity. The results on these aspects will be discussed.