Azolo‐ and Azinopyridazines and some Oxa and Thia Analogs

Tišler, M.; Stanovnik, B.

doi:10.1002/9780470186978.ch3

Cited by 19 publications

(4 citation statements)

References 262 publications

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“…Pyrazole derivatives have received considerable attention in the last two decades because of their diverse biological activities . This class of compounds is reported to show aldose‐reductase inhibitory effect .…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Some Novel Heterocyclic Xylidinyl Amines and Carboxamides

Abdelrazek

Farghaly

Abdelrahman

2014

Journal of Heterocyclic Chem

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The xylidines 1a, 1b undergo condensation with ethyl cyanoacetate 2 and ethyl benzoyl acetate 15 to afford the cyano acetanilides 3a, 3b and the β‐diketones 16a, 16b, respectively. Compounds 3a, 3b react with hydrazine and phenyl hydrazine to afford the azine‐bis derivatives 5a, 5b and 7a, 7b, whereas 16a, 16b react with the same reagents to afford the pyrazolyl amine derivatives 17a, 17b and 18a, 18b, respectively. Compounds 3a, 3b react also with dimethylformamide dimethylacetal to afford the enaminonitriles 8a, 8b, whereas 16a, 16b react with the same reagent to afford only the enaminone 19b. The enaminonitriles 8a, 8b react with hydrazine and phenyl hydrazine to afford also the azine‐bis derivatives 11a, 11b and 14a, 14b, respectively.

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Section: Introductionmentioning

confidence: 99%

Synthesis of Some Novel Heterocyclic Xylidinyl Amines and Carboxamides

Abdelrazek

Farghaly

Abdelrahman

2014

Journal of Heterocyclic Chem

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“…Pyridazine derivatives have received considerable attention in the last two decades because of their diverse biological activities . This class of compounds is reported to show aldose‐reductase inhibitory effect .…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Some New Pyrazole, Pyrimidine, Pyridazine, and Their Fused Derivatives from 3‐Oxo‐3,N‐diphenylpropionamide

Abdelrazek

Elkholy

Salah

et al. 2013

Journal of Heterocyclic Chem

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“…During the past few decades increasing interest in the synthesis and properties of pyridazines, pyridazinones, pyridopyridazines, and pyridopyridazinones has been observed. Pyridopyridazines and pyridopyridazinones show wide spectrum of biological activities as described in the literature [1][2][3][4]. Both classes of substances are of interest as antiviral and cancer therapies, since their structures and properties resemble those of certain current pteridines and purines.…”

Section: Introductionmentioning

confidence: 99%

“…The primary reasons for this are the difficulties associated with the preparation of pyridine starting materials which can easily be transformed into pyridopyridazinones. The only general method for the synthesis of that system involves the cyclization of o-acylpyridinecarboxylic acids [8] and their derivatives (ester [8] and disubstitute amides [9] or of methyl esters of o-cyanopyridinecarboxylic acids [10] with hydrazine and monosubstituted hydrazines). Continuing our interest on the synthesis of pyridazinones [11,12] we hereby present results using a method which was previously employed in only a few cases to the preparation of pyridazinones [13].…”

Section: Introductionmentioning

confidence: 99%