Azobenzene Photoswitches in Proteolysis Targeting Chimeras: Photochemical Control Strategies and Therapeutic Benefits

Negi, Arvind S.; Kieffer, Charline; Voisin‐Chiret, Anne Sophie

doi:10.1002/slct.202200981

Cited by 12 publications

(8 citation statements)

References 46 publications

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“…For example, nanoencapsulation using polymeric interfaces enhances metabolic stability (seen to regulate the programming of blood–brain barrier permeability by hypoxia) [ 89 , 90 ]; application of dendrimers and similar precursor molecules (triphenyl pyridine cores) to improve in vivo and in vitro stability and cellular delivery (some potential applications can be evident with dendrimeric-miRNA nanoformulations against glioblastoma stem cells) [ 91 , 92 , 93 , 94 ]; meso/nano-sized dependent delivery of miRNA (using mesoporous silica nanoparticles to target tumors) [ 95 , 96 , 97 , 98 ]. However, to improve the detection and optical control over miRNA functioning, nanoribbon biosensors (detecting the miRNA in colorectal cancer) [ 99 ], light-activated circular morpholino oligonucleotides [ 100 , 101 ], electrochemical nanohybrid platforms (detecting the label-free miRNA) [ 102 , 103 , 104 ], and chemical surface modification of polymers-based formulation [ 105 , 106 ] were developed.…”

Section: Discussionmentioning

confidence: 99%

MicroRNAs-Based Theranostics against Anesthetic-Induced Neurotoxicity

et al. 2023

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Various clinical reports indicate prolonged exposure to general anesthetic-induced neurotoxicity (in vitro and in vivo). Behavior changes (memory and cognition) are compilations commonly cited with general anesthetics. The ability of miRNAs to modulate gene expression, thereby selectively altering cellular functions, remains one of the emerging techniques in the recent decade. Importantly, engineered miRNAs (which are of the two categories, i.e., agomir and antagomir) to an extent found to mitigate neurotoxicity. Utilizing pre-designed synthetic miRNA oligos would be an ideal analeptic approach for intervention based on indicative parameters. This review demonstrates engineered miRNA’s potential as prophylactics and/or therapeutics minimizing the general anesthetics-induced neurotoxicity. Furthermore, we share our thoughts regarding the current challenges and feasibility of using miRNAs as therapeutic agents to counteract the adverse neurological effects. Moreover, we discuss the scientific status and updates on the novel neuro-miRNAs related to therapy against neurotoxicity induced by amyloid beta (Aβ) and Parkinson’s disease (PD).

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Section: Discussionmentioning

confidence: 99%

MicroRNAs-Based Theranostics against Anesthetic-Induced Neurotoxicity

et al. 2023

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“…Interestingly, spherical-shaped Ag-NPs show an LSPR peak in the blue region of the electromagnetic spectrum, and since some PSs (porphyrins and riboflavin) can be excited using blue light, singlet oxygen ( 1 O 2 ) generation by PSs could be enhanced by LSPR of Ag-NPs [97]. With such surface photochemical tools available to a chemical biologist, help to devise other in-vivo and in-vitro applications, such as improving the azobenzene physiological stability in photoswitches [98][99][100][101]. Various studies implicating the tandem use of the LSPR effect with PDI for Au-NPs conjugates with different PSs cited in the literature [102][103][104].…”

Section: Optical Propertiesmentioning

confidence: 99%

Nanotheranostics to target antibiotic-resistant bacteria: Strategies and applications

et al. 2023

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“…Talking about imidazole acceptability in other chemical biology-oriented approaches, it has shown tremendous potential. These include serving as pH-responsive potent antimicrobials [ 164 ], improving the photophysical characteristics of azo dyes [ 165 , 166 , 167 ], decreasing side toxicities [ 13 , 168 , 169 , 170 ], and successful chemical integration in polymeric materials as theragnostic applications (such as in zeolitic imidazolate framework applications in drug delivery) [ 171 , 172 , 173 , 174 , 175 , 176 , 177 , 178 , 179 , 180 ].…”

Section: Conclusion and Future Perspectivementioning

confidence: 99%

Imidazoles as Serotonin Receptor Modulators for Treatment of Depression: Structural Insights and Structure–Activity Relationship Studies

Goel,

Thapliyal,

Kharb

et al. 2023

Pharmaceutics

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Serotoninergic signaling is identified as a crucial player in psychiatric disorders (notably depression), presenting it as a significant therapeutic target for treating such conditions. Inhibitors of serotoninergic signaling (especially selective serotonin reuptake inhibitors (SSRI) or serotonin and norepinephrine reuptake inhibitors (SNRI)) are prominently selected as first-line therapy for the treatment of depression, which benefits via increasing low serotonin levels and norepinephrine by blocking serotonin/norepinephrine reuptake and thereby increasing activity. While developing newer heterocyclic scaffolds to target/modulate the serotonergic systems, imidazole-bearing pharmacophores have emerged. The imidazole-derived pharmacophore already demonstrated unique structural characteristics and an electron-rich environment, ultimately resulting in a diverse range of bioactivities. Therefore, the current manuscript discloses such a specific modification and structural activity relationship (SAR) of attempted derivatization in terms of the serotonergic efficacy of the resultant inhibitor. We also featured a landscape of imidazole-based development, focusing on SAR studies against the serotoninergic system to target depression. This study covers the recent advancements in synthetic methodologies for imidazole derivatives and the development of new molecules having antidepressant activity via modulating serotonergic systems, along with their SAR studies. The focus of the study is to provide structural insights into imidazole-based derivatives as serotonergic system modulators for the treatment of depression.

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Azobenzene Photoswitches in Proteolysis Targeting Chimeras: Photochemical Control Strategies and Therapeutic Benefits

Cited by 12 publications

References 46 publications

MicroRNAs-Based Theranostics against Anesthetic-Induced Neurotoxicity

MicroRNAs-Based Theranostics against Anesthetic-Induced Neurotoxicity

Nanotheranostics to target antibiotic-resistant bacteria: Strategies and applications

Imidazoles as Serotonin Receptor Modulators for Treatment of Depression: Structural Insights and Structure–Activity Relationship Studies

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