Azo dyes and rat liver glutathione

Neish, W. J. P.; Rylett, Ann

doi:10.1016/0006-2952(63)90120-5

Cited by 22 publications

(2 citation statements)

References 17 publications

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“…Increased activity of -t-glutamyl transpeptidase has previously been found in a number of tumor cells (see, for example, refs. [38][39][40][41][42][43][44][45][46][47] and may reflect an increased requirement for glutathione by certain tumor cells. The regulation of cellular glutathione levels involves not only the activity of -glutamylcysteine synthetase but also depends upon the availability of cysteine moieties whose derivation from extracellular glutathione and transport into the cell involves the activity of y-glutamyl transpeptidase (18).…”

Section: Resultsmentioning

confidence: 99%

High resistance to cisplatin in human ovarian cancer cell lines is associated with marked increase of glutathione synthesis.

Godwin

Meister

O’Dwyer

et al. 1992

Proc. Natl. Acad. Sci. U.S.A.

816

481

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High resistance to cisplatin in human ovarian cancer cell lines is associated with marked increase of glutathione synthesis (y-glutamylcysteine ABSTRACTExposure of human ovarian tumor cell lines to cisplatin led to development of cell lines that exhibited increasing degrees of drug resistance, which were closely correlated with increase of the levels of cellular glutathione. Cell lines were obtained that showed 30-to 1000-fold increases in resistance; these cells also had strikingly increased (13-to 50-fold) levels of glutathione as compared with the drugsensitive cells of origin. These levels of resistance to cisplatin and the cellular glutathione levels are substantially greater than previously reported. Very high cisplatin resistance was associated with enhanced expression of mRNAs for r-glutamylcysteine synthetase and y-glutamyl transpeptidase; immunobots showed increase of -glutamylcysteine synthetase but not of glutathione synthetase. Glutathione S-transferase activity was unaffected, as determined with chlorodinitrobenzene as a substrate. These studies suggest the potential value of examining regulation of glutathione synthesis as an indicator of clinical prognosis. The highly resistant cell lines are proving useful for studying the multiple mechanisms by which tumor cells acquire drug-and radiation-resistance.

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Section: Resultsmentioning

confidence: 99%

High resistance to cisplatin in human ovarian cancer cell lines is associated with marked increase of glutathione synthesis.

Godwin

Meister

O’Dwyer

et al. 1992

Proc. Natl. Acad. Sci. U.S.A.

816

481

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“…Earlier reports indicate that the hepatic GSH level increases following the adminis tration of chemical carcinogens [18,19].…”

Section: Discussionmentioning

confidence: 99%

Intestinal Drug Metabolizing Systems (Phase I and Phase II) in Rats Fed Vitamin A-Deficient Diet and Aflatoxin B<sub>1</sub>

Nair¹,

Chauhan²,

Gupta³

et al. 1982

Digestion

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The combined effect of vitamin A deficiency and aflatoxin-B₁ (AFB₁) on the biphasic xenobiotic biotransformation status of the intestinal mucosa was studied in male weanling rats receiving vitamin A-deficient diet and AFB₁ for 42 days. The findings indicate that the mucosal aminopyrine-N-demethylase and p-nitroanisole O-demethylase representing the mixed function oxidase activity is significantly increased in the gut by the end of 42 days. Of the phase II enzymes studied, UDP-glucuronyl transferase showed a significant decrease, while the glutathione S-transferases and mucosal glutathione showed significant increase. The observations suggest that in vitamin A deficiency, the intestinal xenobiotic metabolism is grossly altered and this effect appears to be further amplified in the concurrent AFB₁ exposure.

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Activation of glutathionase in rat liver during carcinogenesis

Fiala

1969

Naturwissenschaften

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Azo dyes and rat liver glutathione

Cited by 22 publications

References 17 publications

High resistance to cisplatin in human ovarian cancer cell lines is associated with marked increase of glutathione synthesis.

High resistance to cisplatin in human ovarian cancer cell lines is associated with marked increase of glutathione synthesis.

Intestinal Drug Metabolizing Systems (Phase I and Phase II) in Rats Fed Vitamin A-Deficient Diet and Aflatoxin B<sub>1</sub>

Activation of glutathionase in rat liver during carcinogenesis

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