Azithromycin and Oseltamivir Quantification Method Developed and Validated Using Liquid Chromatography-Tandem Mass Spectrometry in Dried Blood Spot
TESIA AISYAH RAHMANIA,
YAHDIANA HARAHAP,
KURNIA SANDY
Abstract:Objective: The development and use of bio-sampling techniques for the analysis of COVID-19 drugs oseltamivir and azithromycin using the Dried Blood Spot technique simultaneously using LC-MS/MS aims to obtain optimal conditions and validated analytical methods using LC-MS/MS according to Food and Drug Administration 2018 recommendations.
Methods: Azithromycin and oseltamivir analyses were performed using LC-MS/MS with C18 Acquity® Bridged Ethylene Hybrid (BEH) column 1.7 m, 100 x 2.1 mm. The matrix sample used … Show more
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