Azithromycin and Dexamethasone Loaded β-Glucan Films for the Treatment of Blepharitis

Alghamdi, Hajer Saleh; Svirskis, Darren; Bunt, Craig R.; Swift, Simon; Rupenthal, Ilva D.

doi:10.2174/2210303106666160506123050

Cited by 4 publications

(2 citation statements)

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“…It is the resistance of a material against the change in its shape without formation of cracks. Usually, it is calculated in percentage and hence called as percentage elongation at break . The percentage elongation can be calculated using the following mathematical expression :

% EB = \frac{Change in length at break}{Initial length} \times 100

…”

Section: Methodsmentioning

confidence: 99%

In vitro and ex vivo assessment of hydrophilic polymer‐ and plasticizer‐based thin buccal films designed by using central composite rotatable design for the delivery of meloxicam

Zaman

Hanif

2017

Adv Polym Technol

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The purpose of the study was to design a dosage form with ability to deliver drug immediately, hence providing rapid relief in certain pain ailments. Meloxicam (MLX) was selected as a model drug and buccal films were designed by using the solvent casting technique. A central composite rotatable design (CCRD) was used as a statistical tool to design and optimize the film formulations. No noticeable interaction was found between the drug and polymer when they were subjected to Fourier transform infrared spectroscopy (FTIR). Scanning electron microscopy (SEM) revealed the smooth surface of the film and uniform mixing of drug and polymer.X-ray diffractometry (XRD) was carried out to observe crystalline and amorphous nature of meloxicam. Differential scanning calorimetric (DSC) analysis was used to investigate the thermal behavior of free drug and drug-loaded formulation. The prepared film showed good mechanical property as folding endurance was found to be greater than 100 in all formulations. The cumulative drug release was found to be more than 80% in initial at dissolution time of 5 min, when the prepared films were subjected to dissolution studies in phosphate buffer at pH 6.8. Thus, it can be concluded that the hydrophilic polymer and plasticizer have definite impact on formulation and characteristics of rapidly dissolving buccal films and have the ability to prepare a suitable immediate release buccal film of meloxicam. K E Y W O R D Sbuccal films, drug delivery system, ex-vivo permeation, hydrophilic polymer, meloxicam, plasticizer, solvent casting method

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% EB = \frac{Change in length at break}{Initial length} \times 100

…”

Section: Methodsmentioning

confidence: 99%

In vitro and ex vivo assessment of hydrophilic polymer‐ and plasticizer‐based thin buccal films designed by using central composite rotatable design for the delivery of meloxicam

Zaman

Hanif

2017

Adv Polym Technol

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“…It helps to predict the ductility of polymers used in formulations and can be measured using a texture analyzer. The percent elongation specifies the stretching ability of a film before being broken down; however, percent elongation can easily be calculated as the difference in the initial length of film and the changed length after film breakage [ 103 , 104 ]. It can be calculated using the following mathematical expression [ 105 ]:

…”

Section: Characterization and Evaluationmentioning

confidence: 99%

An Insight into Preparatory Methods and Characterization of Orodispersible Film—A Review

Salawi

2022

Pharmaceuticals

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Over the past few decades, researchers and companies have been trying to develop novel drug delivery systems to ensure safety, efficacy, compliance, and patient acceptability. Nowadays drug discovery and development are expensive, complex, and time-consuming processes, but trends are moving toward novel drug delivery systems. This delivery system helps to achieve drug response by local and systemic action through different routes. This novel approach of preparing orodispersible films (ODFs) provides benefits to paediatric, geriatric, and bedridden patients. This review paper aims to provide details on the preparation, characterization, and evaluation of ODFs; it also aims to focus on the positive and negative factors that affect film formulation and give an insight into potential drug candidates and polymers for use in ODFs. ODFs are effective, safe, and have good bioavailability as compared to fast-disintegrating tablets. The novel approach has various advantages because it provides instant effects in emergency situations and in schizophrenic and dysphasic patients without the need for taking water, the films disintegrating within a few seconds in the oral cavity. The solvent casting method is the most frequently used technique to develop ODFs, using film-forming polymers, which have a fast disintegration time, improved drug dissolution, and better drug contents.

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Natural polysaccharides: Chemical properties and application in pharmaceutical formulations

Tudu

Samanta

2023

European Polymer Journal

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Azithromycin and Dexamethasone Loaded β-Glucan Films for the Treatment of Blepharitis

Cited by 4 publications

References 0 publications

In vitro and ex vivo assessment of hydrophilic polymer‐ and plasticizer‐based thin buccal films designed by using central composite rotatable design for the delivery of meloxicam

In vitro and ex vivo assessment of hydrophilic polymer‐ and plasticizer‐based thin buccal films designed by using central composite rotatable design for the delivery of meloxicam

An Insight into Preparatory Methods and Characterization of Orodispersible Film—A Review

Natural polysaccharides: Chemical properties and application in pharmaceutical formulations

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