2018
DOI: 10.1016/j.ica.2017.06.032
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Aziridination of alkenes promoted by iron or ruthenium complexes

Abstract: Molecules containing an aziridine functional group are a versatile class of organic synthons due to the presence of a strained three member, which can be easily involved in ring-opening reactions and the aziridine functionality often show interesting pharmaceutical and/or biological behaviours. For these reasons, the scientific community is constantl y interested in developing efficient procedures to introduce an aziridine moiety into organic skeletons and the one-pot reaction of an alkene double bond with a n… Show more

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Cited by 43 publications
(22 citation statements)
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“…Work is currently in progress in that direction. The nature of the isoelectronic cerium(IV)-imido would also be of interest: metal imidosh ave been proposed as reactive intermediates in catalytic nitrenet ransfer and the generation of ammonia, [17] and might offer other new avenuesf or cerium catalysis.…”
mentioning
confidence: 99%
“…Work is currently in progress in that direction. The nature of the isoelectronic cerium(IV)-imido would also be of interest: metal imidosh ave been proposed as reactive intermediates in catalytic nitrenet ransfer and the generation of ammonia, [17] and might offer other new avenuesf or cerium catalysis.…”
mentioning
confidence: 99%
“…Molecules containing an aziridine functional group are a versatile class of organic synthons due to the presence of a strained three-membered ring, which can be easily involved in ring-opening reactions and the aziridine functionality often shows interesting pharmaceutical and/or biological behaviors. Gallo and collaborators recently reviewed the most important results on the catalytic activity of iron and ruthenium porphyrin complexes in the aziridination of alkenes (Scheme 51) [105]. An interesting and straightforward two-step synthesis of N-arylaziridines starting from azides and anilines was efficiently achieved under continuous flow conditions, which was highlighted in the Gallo´s review [106].…”
Section: Catalytic Applications and Azide Transformationsmentioning
confidence: 99%
“…Aziridines are important synthetic intermediates in organic synthesis, medicinal chemistry, and polymer chemistry, Catalytic approaches to their syntheses have rapidly expanded in recent years , . Transition metal‐catalyzed reactions involving nitrene transfer to alkenes have gained prominence in this regard , . Of these latter catalysts, copper(I) and silver(I) scorpionate complexes [tris(pyrazolyl)borates, (normal scorpionates, or Tp R , Scheme , top left), tris(pyrazolyl)methanes (Tpm R or C ‐scorpionates, Scheme , top right), certain C‐heteroscorpionates (Scheme , bottom left), and certain nitrogen‐confused C‐scorpionates (Scheme , bottom right)] have proven adept at catalytically affording aziridines from alkenes and various nitrene sources under mild conditions.…”
Section: Introductionmentioning
confidence: 99%