AZF microdeletions on the Y chromosome of infertile men from Turkey

Sargın, Canan Figen; Berker-Karaüzüm, Sibel; Manguoğlu, Esra; Erdoğru, Ti̇bet; Karaveli, Şeyda; Gülkesen, Kemal Hakan; Baykara, Mehmet; Lülecı, Güven

doi:10.1016/j.anngen.2003.09.002

Cited by 31 publications

(24 citation statements)

References 20 publications

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“…The frequency of sex chromosome anomalies (47,XXY) was seen in the group of azoospermic patients as 8.75% (7/80 patients). These findings are compatible with those of previous studies [5,10,12,13,[26][27][28][29].…”

Section: Discussionsupporting

confidence: 83%

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Cytogenetic and Y chromosome microdeletion screening studies in infertile males with Oligozoospermia and Azoospermia in Southeast Turkey

Balkan

Tekeş

Gedik

2008

J Assist Reprod Genet

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Purpose In view of the genetic risks for the next generation, the importance of careful evaluation of karyotypes and AZF microdeletions in male infertility prior to assisted reproduction is evident. In the present study, it is aimed to investigate the frequency and types of both major chromosomal abnormalities by using standard cytogenetic methods and Y chromosome microdeletions of infertile males with azoospermia and oligozoospermia to give appropriate genetic counseling before assisted reproduction techniques in southeast Turkey. Methods A total of 80 infertile males (52 were azoospermic, 25 oligospermic and 3 asthenospermic) were studied for the cytogenetic evaluation and molecular AZF screening program prior to use of assisted reproduction techniques. A detailed history was taken for each man. Karyotyping was performed on peripheral blood lymphocytes according to standard methods. Polymerase chain reaction (PCR) amplification by using 15 Y-specific sequence-tagged sites of AZF region was performed to screen the microdeletions in the AZF region of Y chromosome.

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Section: Discussionsupporting

confidence: 83%

“…The frequency of AZF microdeletions detected in our sample was only 1.3% (1/80 patients), a value similar to that in the studies previously reported [16,[29][30][31]. However, our finding is lower than that in some previous studies that indicated it between 3 and 55% [2,15,17,27,31].…”

Section: Discussioncontrasting

confidence: 56%

Cytogenetic and Y chromosome microdeletion screening studies in infertile males with Oligozoospermia and Azoospermia in Southeast Turkey

Balkan

Tekeş

Gedik

2008

J Assist Reprod Genet

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“…The prevalence of AZF microdeletion in the patients with azoospermia, oligozoospermia and oligo-asteno-teratozoospermia syndrome was 9.1%, 9.5% and 8.3%, respectively. It has been reported that the prevalence rates of AZF microdeletion are in the range of 4.25% to 23% and 0.1% to 8.5% in patients with non-obstructive azoospermia and oligozoospermia [18][19][20][21][22]. Thus, our data revealed that there was a slightly higher prevalence of AZF microdeletions in oligozoospermic patients than previous studies.…”

Section: Discussioncontrasting

confidence: 44%

Male infertility in China: laboratory finding for AZF microdeletions and chromosomal abnormalities in infertile men from Northeastern China

Wang

Yang

et al. 2010

J Assist Reprod Genet

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Purposes To investigate the frequencies of AZF microdeletions and chromosomal abnormalities in infertile men from Northeastern China. Moreover, to compare the prevalence of these abnormalities with other countries and regions in the world. Methods 305 infertile men were enrolled. A complete semen analysis and reproductive hormones were measured according to standard methods. Multiplex polymerase chain reaction (PCR) amplification using nine specific sequencetagged sites (STS) were used to detect AZF microdeletions. Karyotype analyses were performed on peripheral blood lymphocytes with standard G-banding. Results Of the 305 infertile men, 28 (9.2%) had AZF microdeletions and 26 (8.5%) had chromosomal abnormalities. The most frequent microdeletions were in the AZFc+d, followed by AZFc, AZFb+c+d and AZFa. A total of 19 patients (82.6%) had Klinefelter′s syndrome (47, XXY) in the azoospermic group. Conclusions The freqencies of AZF microdeletions and chromosomal abnormalities in infertile men from Northeastern China were comparable with infertile men from other countries and regions. However, there was a slightly higher prevalence rate of AZF microdeletions in oligozoospermic patients than reported in previous studies.

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“…Similar results have been reported from various populations. Sargin et al (2004) reported 3.3% AZF deletions in Turkish infertile men; Katagiri et al (2004) reported 3.4% among infertile North American men and a frequency of 4% was reported by Machatkova et al (2003) in Czech infertile men while 4.5% in Croatia by Sertic et al (2001). However, a wide variation of such microdeletions has been observed in different geographical regions.…”

Section: Azf Deletionsmentioning

confidence: 96%

“…El Awady et al (2004) and Loginova et al (2003) each reported one such case amongst infertile men studied by them. Sargin et al (2004) did not find any case of AZFa+b+c deletion amongst 61 Turkish infertile males. Similar to the present study, wherein no AZFa+b+c deletion was observed in 103 Czech infertile men, Yang et al (2003) also did not find any such case in 134 azoospermics from China.…”

Section: Azf Deletionsmentioning

confidence: 96%

Comparative Study of AZF Deletions and TSPY Gene Variation in Czech and Indian Infertile Men

Singh

Vrtěl

Vodička

et al. 2006

International Journal of Human Genetics

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The human Y chromosome harbours genes that are essential for spermatogenesis. Most of these genes lie in the male-specific region (MSY) of Y chromosome. Microdeletions of AZF within the MSY have been reported in infertile men. Widely different frequencies of such deletions (0-55%) have been reported from different populations. TSPY is another gene located in the MSY region that plays a significant role in spermatogenesis. It is a multi-copy gene but the role its gene copy numbers play in infertility is not yet evaluated. The present study was undertaken on infertile men from Czech Republic and India to ascertain the relative and comparative role of AZF deletions and of TSPY copy numbers.

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AZF microdeletions on the Y chromosome of infertile men from Turkey

Cited by 31 publications

References 20 publications

Cytogenetic and Y chromosome microdeletion screening studies in infertile males with Oligozoospermia and Azoospermia in Southeast Turkey

Cytogenetic and Y chromosome microdeletion screening studies in infertile males with Oligozoospermia and Azoospermia in Southeast Turkey

Male infertility in China: laboratory finding for AZF microdeletions and chromosomal abnormalities in infertile men from Northeastern China

Comparative Study of AZF Deletions and TSPY Gene Variation in Czech and Indian Infertile Men

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