Azelnidipine, a New Calcium Channel Blocker, Promotes Skin Wound Healing in Diabetic Rats

Bagheri, Mansooreh; Jahromi, Behnam Moein; Mirkhani, Hossein; Solhjou, Zhabiz; Noorafshan, Ali; Zamani, Ali; Amirghofran, Zahra

doi:10.1016/j.jss.2011.02.039

Cited by 36 publications

(24 citation statements)

References 37 publications

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“…Studies on Iris germanicain animal models were found to be a potent anti-inflammatory, antimicrobial and immunomodulatory herb (Ibrahim et al, 2012;Bagheri et al, 2011;Xie et al, 2014;Tundis et al, 2015). In current study, stereological investigation of specimens showed higher rates of granulation tissue formation that improved in treatment group.…”

Section: Discussionsupporting

confidence: 45%

The wound healing effect of <i>Iris forentina</i> on full thickness excisional skin wounds: A histomorphometrical study

Mirmalek

Parsa

et al. 2015

Bangladesh J Pharmacol

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Iris florentina is an ancient herbal remedy which was prescribed by many physicians due to its positive effects on dermatological problems, specifically skin wounds. Hence, we aimed to investigate the effects of this agent on fullthickness excisional skin wounds in laboratory rats. Three groups of rats (180 ± 20 g; n=8) with 1 cm diameter full-thickness excisional skin wound received daily treatment with I. florentina 10% ointment, and a group with no treatment. By using histomorphometrical methods, the amount of fibroblast population, collagen bundle synthesis, and vascularization (length density, mean diameter and volume density of the vessels) were estimated. Outcome of the study exhibited that the increase in fibroblast proliferation rate, collagen bundle synthesis, vascular density and vascular mean diameter in I. florentina treated group were significant in comparison to the untreated group (p<0.05). Results indicated that I. florentina can be prescribed as a herbal medicine for treatment of skin wounds or be used as an additional agent for today's common medicines. Article Info

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Section: Discussionsupporting

confidence: 45%

The wound healing effect of <i>Iris forentina</i> on full thickness excisional skin wounds: A histomorphometrical study

Mirmalek

Parsa

et al. 2015

Bangladesh J Pharmacol

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“…Other calcium channel blockers were used as healing agents in previous studies, but amlodipine was not (16, 27). …”

Section: Discussionmentioning

confidence: 99%

“…One study recently showed that azelnidipine (AZL), a new calcium channel blocker with antioxidant properties, would enhance wound healing in streptozotocin-induced diabetic rats by restoring NO synthesis (27). In this study, amlodipine significantly enhanced wound healing in rabbit and decreased the days needed for complete healing compared to control group.…”

Section: Discussionmentioning

confidence: 99%

Wound Healing Potential of Topical Amlodipine in Full Thickness Wound of Rabbit

Hemmati

Forushani

Asgari

2014

Jundishapur J Nat Pharm Prod

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Background: Wound healing is a complicated and integrated process. Researches have indicated the wound healing effects of calcium channel blockers in animal models in recent years. Objectives: The aim of this study was to evaluate the wound-healing activity of amlodipine as a calcium channel blocker and combination of amlodipine with phenytoin on excisional cutaneous wound models in rabbit. Materials and Methods: Animals were divided into 5 groups (n = 5). The control group was treated topically with eucerin. The untreated control group received no healing agent. The reference standard group was treated with phenytoin1%. A treatment group was treated with amlodipine 1%. The last group was treated with combination of amlodipine1% and phenytoin 1%. Results: Results indicated significant difference between days needed for complete healing in both of the treatment groups. Wound closure was completed on 13th day and 9th day in amlodipine and combination groups respectively. Conclusions: In conclusion, calcium channel blockers can be used to enhance wound healing, especially if this treatment becomes with phenytoin. Further studies are needed to find out the mechanism of this healing effect.

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“…One of the most important concerns of diabetic patients is delayed wound healing which can lead to serious complications such as limb amputations, organ dysfunctions, cosmetic impairments, infections, sepsis, and even death [2]. Actually wound healing as a dynamic, multicellular, and normal biological process in the human body has four phases: hemostasis, inflammation, proliferation, and remodeling; for a successful repair all four factors must occur properly [3].…”

Section: Introductionmentioning

confidence: 99%

TopicalHypericum perforatumImproves Tissue Regeneration in Full-Thickness Excisional Wounds in Diabetic Rat Model

Yadollah-Damavandi

Chavoshi-Nejad

Jangholi

et al. 2015

Evidence-Based Complementary and Alternative Medicine

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Delayed wound healing process is one of the most important concerns in diabetes. Healing of wounds has four phases, namely, hemostasis, inflammation, proliferation, and remodeling. For a successful repair, all four factors must occur properly. Hence, we aimed to evaluate the healing effects of Hypericum perforatum (HP) on full-thickness diabetic skin wounds by using stereological methods. Forty-eight female diabetic rats were randomly divided into four groups (n = 12): gel base treated group, HP 5% gel treated group, HP 10% gel treated group, and the control group which received no treatment. A circular 1 cm2 full-thickness wound was created on the animal's neck and wound area was measured every three days. After sacrificing the animals, skin samples were fixed and prepared for stereological evaluations. Based on the results, HP treated group showed faster wound closure rate in comparison with control and vehicle groups (P < 0.05). In addition, numerical density of fibroblasts, volume density of collagen bundles, and mean diameter and volume densities of the vessels in HP group were significantly higher than control and vehicle groups. The results of this study showed that HP has the ability to improve tissue regeneration by enhancing fibroblast proliferation, collagen bundle synthesis, and revascularization.

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Azelnidipine, a New Calcium Channel Blocker, Promotes Skin Wound Healing in Diabetic Rats

Cited by 36 publications

References 37 publications

The wound healing effect of <i>Iris forentina</i> on full thickness excisional skin wounds: A histomorphometrical study

The wound healing effect of <i>Iris forentina</i> on full thickness excisional skin wounds: A histomorphometrical study

Wound Healing Potential of Topical Amlodipine in Full Thickness Wound of Rabbit

TopicalHypericum perforatumImproves Tissue Regeneration in Full-Thickness Excisional Wounds in Diabetic Rat Model

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