Viburnum erubescens
Wall.
, Rhododendron arboretum
Sm.
, Eurya japonica
Thumb.
, Symplocos lucida
(Thunb.) Siebold & Zucc, and
Symplocos pyrifolia
Wall. ex G. Don are extensively used by the native and ethnic populations of the South-Eastern Himalayan region for several dermatological conditions, yet their phytochemical composition remained largely unknown. Therefore, the aim of the study was to explore the therapeutically relevant volatile phytochemical compositions and study the molecular interactions against intracellular cytoregulatory transcription factors. Leaves of the five plants were subjected to Gas chromatography-Mass spectrometry (GCMS) post silylation derivation. The results were further analyzed using multivariate statistical methods such as Principal Component Analysis (PCA) and Hierarchical Cluster Analysis (HCA). A total of 115 compounds were identified in the five plants. Multivariate analysis revealed optimum metabolomic correlation between
S. pyrifolia
and
S. lucida
(0.876), whereas lowest correlation was found between
E. japonica
and
V. erubescens
(−0.242). Arbutin, β-amyrin, betulin, β-sitosterol and stigmasterol demonstrated highest interaction with the molecular targets. Collectively, the present study revealed the bioactive volatile phytochemicals responsible the therapeutic uses against diverse skin conditions.