Azelaic acid 15% gel for treatment of rosacea

Abstract

Although the pathophysiology of rosacea has not been completely elucidated, this chronic, relapsing dermatosis appears to be caused in part by the release of proinflammatory mediators from neutrophils. The effectiveness of some interventions, including topical azelaic acid and metronidazole, may be related to their anti-inflammatory activity. A 15% gel formulation of azelaic acid (Finacea ® 15% Gel), with improved pharmacological properties compared with an older azelaic acid 20% cream, has been shown to reduce erythema and inflammatory lesions in rosacea. Topical azelaic acid 15% gel was found to be more effective but transiently more irritating than topical metronidazole 0.75% gel in moderate papulopustular rosacea. Newer agents such as azelaic acid 15% gel provide physicians and patients with an expanded range of treatment options.

Azelaic Acid Attenuatesrotenone-Induced Behavioural Alterations in Parkinson’s Disease Rat Model

“…In this experiment, AA was evaluated against the behavioral changes induced by the rotenone in rats. AA has been proven for its antioxidant activity in skin disorder and neuroprotective effect in in vitro experiment (Elewski, 2006;Gan et al, 2011).…”

“…Azelaic acid (AA) is a dicarboxylic acid found mainly in wheat, rye, and barley. It has been proved for its antioxidant activity (Elewski, 2006) and neuroprotective activity in in vitro model (Gan et al, 2011a). Thus, in the current study, AA was evaluated for its role in the treatment of PD.…”