Az őrszemnyirokcsomó-áttét kimutatása 4 mm-nél vastagabb melanomában esélyt ad ígéretes adjuváns kezelésre

Kocsis, Ádám; Mezőlaki, Noémi; Porkoláb, Dorottya; Mohos, Gábor; Kis, Erika; Várga, J.; Baltás, Eszter; Ócsai, Henriette; Korom, Irma; Varga, Erika; Németh, István; Kemény, Lajos; Oláh, Judit

doi:10.1556/650.2020.31835

Cited by 1 publication

(1 citation statement)

References 27 publications

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“…The most important prognostic factor in intermediate and thick melanoma is sentinel lymph node (SLN) positivity [30,[40][41][42]. Nevertheless, there is no uniform consensus on the link between regression and lymph node metastasis.…”

Section: Many Prognostic Factors Have Been Investigated and Identifie...mentioning

confidence: 99%

Tumour regression predicts better response to interferon therapy in melanoma patients: a retrospective single centre study

Mezőlaki,

Baltás,

Ócsai

et al. 2023

Melanoma Research

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We hypothesise that regression may have an impact on the effectiveness of adjuvant IFN therapy, based on its role in the host immune response. Our purpose is to investigate regression and ulceration as prognostic factors in case of interferon-alpha (IFN)-treated melanoma patients. We followed 357 IFN-treated melanoma patients retrospectively, investigating progression-free survival (PFS) and overall survival (OS) depending on the presence of ulceration and regression. A Kaplan–Meier analysis was performed, and we used a Cox regression analysis to relate risk factors. The survival function of the Cox regression was used to measure the effect of regression and ulceration on PFS and OS depending on the Breslow thickness (T1–T4) of the primary tumour. Regression was significantly positively related to PFS (P = 0.0018, HR = 0.352) and OS (P = 0.0112, HR = 0.380), while ulceration showed a negative effect (PFS: P = 0.0001, HR = 2.629; OS: P = 0.0001, HR = 2.388). They influence survival independently. The most favourable outcome was measured in the regressed/non-ulcerated group, whereas the worse was in the non-regressed/ulcerated one. Of risk factors, Breslow thickness is the most significant predictor. The efficacy of regression is regardless of Breslow thickness, though the more favourable the impact of regression was in the thicker primary lesions. Our results indicate that regression is associated with a more favourable outcome for IFN-treated melanoma patients, whereas ulceration shows an inverse relation. Further studies are needed to analyse the survival benefit of regression in relation to innovative immune checkpoint inhibitors.

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Section: Many Prognostic Factors Have Been Investigated and Identifie...mentioning

confidence: 99%

Tumour regression predicts better response to interferon therapy in melanoma patients: a retrospective single centre study

Mezőlaki,

Baltás,

Ócsai

et al. 2023

Melanoma Research

Self Cite

View full text Add to dashboard Cite

show abstract

Az őrszemnyirokcsomó-áttét kimutatása 4 mm-nél vastagabb melanomában esélyt ad ígéretes adjuváns kezelésre

Cited by 1 publication

References 27 publications

Tumour regression predicts better response to interferon therapy in melanoma patients: a retrospective single centre study

Tumour regression predicts better response to interferon therapy in melanoma patients: a retrospective single centre study

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