Hypothyroidism is increasing worldwide and female predominate male i.e.-1 out of 50 female and 1 out of 1000 male. TSH (thyroid stimulating Hormone, a secretion of pituitary gland) level is adjudged as an index of diagnosis of thyroid function. Hypothyroid status needs L thyroxin supplementation but its variable schedule poses metabolic dysfunction Objective of Study: To adjudge clinical effect of early morning fixed time intake of L thyroxin verses unscheduled administration in bioregulation of TSH level and metabolic process Material & Methods: