Ayurvedic Treatment of Diabetic Retinopathy- A Review

Kumar, Krishna Moorthy Sangeeth

doi:10.31142/ijahm/v8i3.05

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…O. basilicum has been demonstrated to possess a diverse range of beneficial effects, including anti-stress, antipyretic, analgesic, anti-inflammatory, immune-modulatory, hypolipidemic, antidiabetic, and hepatoprotective properties. Additionally, a wealth of evidence supports the anticancer properties of O. basilicum leaves (Kumar & Kumari, 2015). The bioactive constituent present in O. basilicum exhibits low solubility in water, leading to inadequate absorption in biological fluids.…”

Section: Introductionmentioning

confidence: 99%

Microfluidic‐based nanoemulsion of Ocimum basilicum extract: Constituents, stability, characterization, and potential biomedical applications for improved antimicrobial and anticancer properties

Ahmad,

Al‐dolaimy,

Kzar

et al. 2023

Microscopy Res & Technique

View full text Add to dashboard Cite

This paper reports on the findings from a study that aimed to identify and characterize the constituents of Ocimum basilicum extract using gas chromatography–mass spectrometry (GC–MS) analysis, as well as assess the physicochemical properties and stability of nanoemulsions formulated with O. basilicum extract. The GC–MS analysis revealed that the O. basilicum extract contained 22 components, with Caryophyllene and Naringenin identified as the primary active constituents. The nanoemulsion formulation demonstrated excellent potential for use in the biomedical field, with a small and uniform particle size distribution, a negative zeta potential, and high encapsulation efficiency for the O. basilicum extract. The nanoemulsions exhibited spherical morphology and remained physically stable for up to 6 months. In vitro release studies indicated sustained release of the extract from the nanoemulsion formulation compared to the free extract solution. Furthermore, the developed nanoformulation exhibited enhanced anticancer properties against K562 cells while demonstrating low toxicity in normal cells (HEK293). The O. basilicum extract demonstrated antimicrobial activity against Pseudomonas aeruginosa, Candida albicans, and Staphylococcus epidermidis, with a potential synergistic effect observed when combined with the nanoemulsion. These findings contribute to the understanding of the constituents and potential applications of O. basilicum extract and its nanoemulsion formulation in various fields, including healthcare and pharmaceutical industries. Further optimization and research are necessary to maximize the efficacy and antimicrobial activity of the extract and its nanoformulation.Research Highlights This study characterized the constituents of O. basilicum extract and assessed the physicochemical properties and stability of its nanoemulsion formulation. The O. basilicum extract contained 22 components, with Caryophyllene and Naringenin identified as the primary active constituents. The nanoemulsion formulation demonstrated excellent potential for biomedical applications, with sustained release of the extract, low toxicity, and enhanced anticancer and antimicrobial properties. The findings contribute to the understanding of the potential applications of O. basilicum extract and its nanoemulsion formulation in healthcare and pharmaceutical industries, highlighting the need for further optimization and research.

show abstract

Section: Introductionmentioning

confidence: 99%