Ayurvedic processed seeds of nux-vomica: Neuropharmacological and chemical evaluation

Katiyar, Chandrakant; Kumar, Abhishek; Bhattacharya, Sujit; Singh, Randhir

doi:10.1016/j.fitote.2009.08.023

Cited by 23 publications

(12 citation statements)

References 4 publications

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“…[ 28 61 ] Classical method of purification includes soaking of Kupīlu seeds in liquid media (one after another) for 3–20 days. The liquid media include kāñji (soaking for 3 days), Godugdha (boiling for 3 h), Gomūtra (7 days soaking) and Goghṛta (fried till brownish red in color and swollen)[ 3 ] whereas traditional practitioners use castor oil ( Eraṇḍa taila ) instead of grita to fry[ 62 ] or immerse the seeds in the exudates scraped from the fresh leaves and stems of Aloe vera ( ghṛtakumārī ) for 15 days, followed by ginger juice ( Ārdraka svarasa ) for 7 days[ 63 ] for purification. After Śodhana process, the seeds are washed with lukewarm water where the outer seed coat and embryo are removed from the cotyledons.…”

Section: Various Toxic Medicinal Plants and Their śOdhana mentioning

confidence: 99%

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Śodhana: An Ayurvedic process for detoxification and modification of therapeutic activities of poisonous medicinal plants

et al. 2015

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Ayurveda involves the use of drugs obtained from plants, animals, and mineral origin. All the three sources of drugs can be divided under poisonous and nonpoisonous category. There are various crude drugs, which generally possess unwanted impurities and toxic substances, which can lead to harmful health problems. Many authors have reported that not all medicinal plants are safe to use since they can bear many toxic and harmful phytoconstituents in them. Śodhana (detoxification/purification) is the process, which involves the conversion of any poisonous drug into beneficial, nonpoisonous/nontoxic ones. Vatsanābha (Aconitum species), Semecarpus anacardium, Strychnos nux-vomica, Acorus calamus, Abrus precatorius etc., are some of the interesting examples of toxic plants, which are still used in the Indian system of medicine. Aconite, bhilawanols, strychnine, β–asarone, abrin are some of the toxic components present in these plants and are relatively toxic in nature. Śodhana process involves the purification as well as reduction in the levels of toxic principles which sometimes results in an enhanced therapeutic efficacy. The present review is designed to extensively discuss and understand the scientific basis of the alternative use of toxic plants as a medicine after their purification process.

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Section: Various Toxic Medicinal Plants and Their śOdhana mentioning

confidence: 99%

“…The detoxification study of S. nux-vomica seeds was performed by Katiyar et al [ 62 ] by traditional methods using aloe and ginger juice, by frying in cow ghee and by boiling in cow milk. All the treated samples were extracted with ethanol.…”

Section: Various Toxic Medicinal Plants and Their śOdhana mentioning

confidence: 99%

Śodhana: An Ayurvedic process for detoxification and modification of therapeutic activities of poisonous medicinal plants

et al. 2015

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“…Strychnos nux-vomica: The effect of detoxification on Strychnos nux-vomica seeds by traditional processing with aloe and ginger juices, by frying in cow ghee, and by boiling in cow milk was investigated. The ethanolic extracts of these samples were subjected to spontaneous motor activity, pentobarbitoneinduced hypnosis, PTZ induced convulsions, diazepam assisted protection, and morphine-induced catalepsy (Katiyar et al, 2010).…”

Section: Prevalence Of Epilepsymentioning

confidence: 99%

Anticonvulsant potential of some medicinal plants and their beneficial properties

Asif¹

2013

TANG [HUMANITAS MEDICINE]

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Epilepsy has now become the most serious brain disorder. A number of synthetic antiepileptic drugs are available in practice, however their effectiveness does not grip true with the entire population suffering from epilepsy. Traditional systems of medicine are popular in developing countries and most of the population relies on traditional medicines for their primary health care need. Medicinal plants to be an important source of traditional medicines. Various plants are used for the treatment of epilepsy in traditional system of medicines and various plants are yet to be scientifically investigated. Phytoconstituents have been the basis of treatment of human diseases including epilepsy. Herbal products are extensively used for the treatment of many diseases worldwide and where allopathic fails or has severe side effects. Psycho neural drugs are also have very serious side effects like physical dependence, tolerance, deterioration of cognitive function and effect on respiratory, digestive and immune system. So the treatments through herbal medicines are widely used across the world due to their wide applicability and therapeutic efficacy with least side effects, which in turn has accelerated the research regarding natural therapy. In this review we have summarized some herbal antiepileptics.

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“…Its seeds have psychotomimetic actions and also exhibit stimulant and depressant actions affecting the CNS (Sonavane et al, 2002). El-Alfy et al (2009) compared the effects of oral and intraperitoneal administration of this species; oral Back pain due to hypertension of an rLung nature; poisoning with fever c Anticonvulsant (Parida et al, 2010); antiepileptic (Katiyar et al, 2010); nicotinic antagonist (Daly, 2005); reduces alcohol consumption (Sukul et al, 2001) Sok tza karpo d affected by rLung; to treat excess of heat in the stomach Neuropathic pain (Lionnet et al, 2010); aphrodisiac (Tajuddin et al, 2004); memory enhancer (Halder et al, 2011); anticonvulsant (Pourgholami et al, 1999) Enhances digestive power; rLung disorders; improves blood circulation; purifies the blood Neuroprotective (Wattanathorn et al, 2011); nootropic (Joshi & Parle, 2006); memory enhancer (Wattanathorn et al, 2011); anxiolytic (Vishwakarma et al, 2002) a Uses referred to rLung imbalance, other than neuropsychiatric disorders, which were corroborated by pharmacological studies; and uses referred to neuropsychiatric disorders, corroborated or not by pharmacological studies. on the other hand, the CNS depressant, analgesic, and hypothermic effects were observed.…”

Section: Enhances Appetitementioning

confidence: 99%

Formulas Used by Tibetan Doctors at Men‐Tsee‐Khang in India for the Treatment of Neuropsychiatric Disorders and Their Correlation with Pharmacological Data

Antonio

Kozasa

Galduróz

et al. 2012

Phytotherapy Research

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The aim of the present study was to identify formulas used at Men-Tsee-Khang (Tibetan Medical and Astrological Institute), India, for the treatment of neuropsychiatric disorders and to compare the Tibetan usage of particular ingredients with pharmacological data from the scientific database. Using ethnographic methods, five doctors were selected and interviewed. A correlation was observed between central nervous system disorders and rLung, one of the three humors in Tibetan medicine, which imbalance is the source of mental disorders, and ten multi-ingredient formulas used to treat the imbalance of this particular humor were identified. These formulas utilize 61 ingredients; among them were 48 plant species. Each formula treats several symptoms related to rLung imbalance, so the plants may have therapeutic uses distinct from those of the formulas in which they are included. Myristica fragrans, nutmeg, is contained in 100% of the formulas, and its seeds exhibit stimulant and depressant actions affecting the central nervous system. Preclinical and clinical data from the scientific literature indicate that all of the formulas include ingredients with neuropsychiatric action and corroborate the therapeutic use of 75.6% of the plants. These findings indicate a level of congruence between the therapeutic uses of particular plant species in Tibetan and Western medicines.

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Ayurvedic processed seeds of nux-vomica: Neuropharmacological and chemical evaluation

Cited by 23 publications

References 4 publications

Śodhana: An Ayurvedic process for detoxification and modification of therapeutic activities of poisonous medicinal plants

Śodhana: An Ayurvedic process for detoxification and modification of therapeutic activities of poisonous medicinal plants

Anticonvulsant potential of some medicinal plants and their beneficial properties

Formulas Used by Tibetan Doctors at Men‐Tsee‐Khang in India for the Treatment of Neuropsychiatric Disorders and Their Correlation with Pharmacological Data

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